Abstract
We explore the problem of identification and control of living cell populations. We describe how de novo control systems can be interfaced with living cells and used to control their behavior. Using computer controlled light pulses in combination with a genetically encoded light-responsive module and a flow cytometer, we demonstrate how in silico feedback control can be configured to achieve precise and robust set point regulation of gene expression. We also outline how external control inputs can be used in experimental design to improve our understanding of the underlying biochemical processes.
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© 2014 Springer-Verlag London
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Khammash, M., Lygeros, J. (2014). Identification and Control of Cell Populations. In: Baillieul, J., Samad, T. (eds) Encyclopedia of Systems and Control. Springer, London. https://doi.org/10.1007/978-1-4471-5102-9_92-1
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DOI: https://doi.org/10.1007/978-1-4471-5102-9_92-1
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Publisher Name: Springer, London
Online ISBN: 978-1-4471-5102-9
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