Abstract
In this work, we aimed at predicting children’s fluid intelligence scores based on structural T1-weighted MR images from the largest long-term study of brain development and child health. The target variable was regressed on a data collection site, sociodemographic variables, and brain volume, thus being independent to the potentially informative factors, which were not directly related to the brain functioning. We investigated both feature extraction and deep learning approaches as well as different deep CNN architectures and their ensembles. We proposed an advanced architecture of VoxCNNs ensemble, which yields MSE (92.838) on a blind test.
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References
Carroll, J.B.: Human Cognitive Abilities: A Survey of Factor-Analytic Studies. Cambridge University Press, Cambridge (1993)
RobertWCox: AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. In: Computers and Biomedical Research, vol. 29, no. 3, pp. 162–173 (1996)
Smith, S.M.: Fast robust automated brain extraction. Hum. Brain Mapp. 17(3), 143–155 (2002)
Avants, B.B., Tustison, N., Song, G.: Advanced normalization tools (ANTS). Insight j 2, 1–35 (2009)
Rohlfing, T., et al.: The SRI24 multichannel atlas of normal adult human brain structure. Hum. Brain Mapp. 31(5), 798–819 (2010)
Sadananthan, S.A., et al.: Skull stripping using graph cuts. NeuroImage 49(1), 225–239 (2010)
Avants, B.B., et al.: An open source multivariate framework for n-tissue segmentation with evaluation on public data. Neuroinformatics 9(4), 381–400 (2011)
Iglesias, J.E., et al.: Robust brain extraction across datasets and comparison with publicly available methods. IEEE Trans. Med. Imaging 30(9), 1617–1634 (2011)
Burnaev, E.V., Prikhod’ko, P.V.: On a method for constructing ensembles of regression models. Autom. Remote Control 74(10), 1630–1644 (2013)
Burnaev, E., Vovk, V.: Efficiency of conformalized ridge regression. In: Balcan, M.F., Feldman, V., Szepesvari, C. (eds.) Proceedings of the 27th Conference on Learning Theory. Proceedings of Machine Learning Research, PMLR, Barcelona, Spain, 13–15 Jun 2014, vol. 35, pp. 605–622 (2014)
Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)
Brown, S.A., et al.: The national consortium on alcohol and neurodevelopment in adolescence (NCANDA): a multisite study of adolescent development and substance use. J. Stud. Alcohol Drugs 76(6), 895–908 (2015)
Burnaev, E., Zaytsev, A.: Surrogate modeling of multifidelity data for large samples. J. Commun. Technol. Electron. 60(12), 1348–1355 (2015)
Szegedy, C., et al.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015)
Tompson, J., et al.: Efficient object localization using convolutional networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 648–656 (2015)
Burnaev, E., Erofeev, P.: The influence of parameter initialization on the training time and accuracy of a nonlinear regression model. J. Commun. Technol. Electron. 61(6), 646–660 (2016). ISSN 1555-6557
Burnaev, E., Nazarov, I.: Conformalized Kernel ridge regression. In: 2016 15th IEEE International Conference on Machine Learning and Applications (ICMLA), pp. 45–52 (2016)
Canziani, A., Paszke, A., Culurciello, E.: An analysis of deep neural network models for practical applications. arXiv preprint arXiv:1605.07678 (2016)
Goetz, M., et al.: DALSA: domain adaptation for supervised learning from sparsely annotated MR images. IEEE Trans. Med. Imaging 35(1), 184–196 (2016)
He, K., et al.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on computer vision and pattern recognition, pp. 770–778 (2016)
Hosseini-Asl, E., Gimel’farb, G., El-Baz, A.: Alzheimer’s disease diagnostics by a deeply supervised adaptable 3D convolutional network. arXiv preprint arXiv:1607.00556 (2016)
Milletari, F., Navab, N., Ahmadi, S.-A.: V-net: fully convolutional neural networks for volumetric medical image segmentation. In: 2016 Fourth International Conference on 3D Vision (3DV), pp. 565–571. IEEE (2016)
Paul, E.J., et al.: Dissociable brain biomarkers of UID intelligence. NeuroImage 137, 201–211 (2016)
Szegedy, C., et al.: Rethinking the inception architecture for computer vision. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2818–2826 (2016)
Ghafoorian, M., et al.: Transfer learning for domain adaptation in MRI: application in brain lesion segmentation. In: Descoteaux, M., Maier-Hein, L., Franz, A., Jannin, P., Collins, D.L., Duchesne, S. (eds.) MICCAI 2017. LNCS, vol. 10435, pp. 516–524. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66179-7_59
Hunyadi, B., et al.: Tensor decompositions and data fusion in epileptic electroencephalography and functional magnetic resonance imaging data. Wiley Interdiscip. Rev.: Data Min. Knowl. Discov. 7(1), e1197 (2017)
Korolev, S., et al.: Residual and plain convolutional neural networks for 3D brain MRI classification. In: IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017), pp. 835–838. IEEE (2017)
Lu, H., et al.: When unsupervised domain adaptation meets tensor representations. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 599–608 (2017)
Pfefferbaum, A., et al.: Altered brain developmental trajectories in adolescents after initiating drinking. Am. J. Psychiatry 175(4), 370–380 (2017)
Zaytsev, A., Burnaev, E.: Large scale variable fidelity surrogate modeling. Ann. Math. Artif. Intell. 81(1), 167–186 (2017). ISSN 1573-7470
Zaytsev, A., Burnaev, E.: Minimax approach to variable fidelity data interpolation. In: Singh, A., Zhu, J. (eds.) Proceedings of the 20th International Conference on Artificial Intelligence and Statistics, Proceedings of Machine Learning Research, PMLR, Fort Lauderdale, FL, USA, 20–22 Apr 2017, vol. 54, pp. 652–661 (2017)
Chen, H., et al.: VoxResNet: deep voxelwise residual networks for brain segmentation from 3D MR images. NeuroImage 170, 446–455 (2018)
Hagler, D.J., et al.: Image processing and analysis methods for the adolescent brain cognitive development study. bioRxiv, p. 457739 (2018)
Ivanov, S., et al.: Learning connectivity patterns via graph kernels for fMRI-based Depression Diagnostics. In: Proceedings of IEEE International Conference on Data Mining Workshops (ICDMW), pp. 308–314 (2018)
Kuleshov, A., Bernstein, A., Burnaev, E.: Conformal prediction in manifold learning. In: Gammerman, A., et al. (eds.) Proceedings of the Seventh Workshop on Conformal and Probabilistic Prediction and Applications, Proceedings of Machine Learning Research, PMLR, vol. 91. pp. 234–253 (2018)
Notchenko, A., Kapushev, Y., Burnaev, E.: Large-scale shape retrieval with sparse 3D convolutional neural networks. In: van der Aalst, W.M.P., et al. (eds.) AIST 2017. LNCS, vol. 10716, pp. 245–254. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-73013-4_23
Pominova, M., et al.: Voxelwise 3D convolutional and recurrent neural networks for epilepsy and depression diagnostics from structural and functional MRI Data. In: 2018 IEEE International Conference on Data Mining Workshops (ICDMW), pp. 299–307. IEEE (2018)
Sharaev, M., et al.: MRI-based diagnostics of depression concomitant with epilepsy: in search of the potential biomarkers. In: Proceedings of IEEE 5th International Conference on Data Science and Advanced Analytics, pp. 555–564 (2018)
Sharaev, M., et al.: Pattern recognition pipeline for neuroimaging data. In: Pancioni, L., Schwenker, F., Trentin, E. (eds.) ANNPR 2018. LNCS (LNAI), vol. 11081, pp. 306–319. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-99978-4_24
Zhu, M., Liu, B., Li, J.: Prediction of general fluid intelligence using cortical measurements and underlying genetic mechanisms. In: IOP Conference Series: Materials Science and Engineering, vol. 381, no. 1, p. 012186. IOP Publishing (2018)
Eckle, K., Schmidt-Hieber, J.: A comparison of deep networks with ReLU activation function and linear spline-type methods. Neural Netw. 110, 232–242 (2019)
Acknowledgements
The work was supported by the Russian Science Foundation under Grant 19-41-04109.
The considered problem was formulated in the scope of the Project “Machine Learning and Pattern Recognition for the development of diagnostic and clinical prognostic prediction tools in psychiatry, borderline mental disorders, and neurology”, granted by Skoltech Biomedical Initiative Program, Skolkovo Institute of Science and Technology, Moscow, Russia.
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Pominova, M. et al. (2019). Ensemble of 3D CNN Regressors with Data Fusion for Fluid Intelligence Prediction. In: Pohl, K., Thompson, W., Adeli, E., Linguraru, M. (eds) Adolescent Brain Cognitive Development Neurocognitive Prediction. ABCD-NP 2019. Lecture Notes in Computer Science(), vol 11791. Springer, Cham. https://doi.org/10.1007/978-3-030-31901-4_19
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