Abstract
More than 55,000 people world-wide die from Cardiovascular Disease (CVD) each day. Calcification of the abdominal aorta is an established marker of asymptomatic CVD. It can be observed on scans taken for vertebral fracture assessment from Dual Energy X-ray Absorptiometry machines. Assessment of Abdominal Aortic Calcification (AAC) and timely intervention may help to reinforce public health messages around CVD risk factors and improve disease management, reducing the global health burden related to CVDs. Our research addresses this problem by proposing a novel and reliable framework for automated “fine-grained” assessment of AAC. Inspired by the vision-to-language models, our method performs sequential scoring of calcified lesions along the length of the abdominal aorta on DXA scans; mimicking the human scoring process.
S. Z. Gilani and N. Sharif—Joint First Authors.
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References
Bernardi, R., et al.: Automatic description generation from images: a survey of models, datasets, and evaluation measures. J. Artif. Intell. Res. 55, 409–442 (2016)
Chaplin, L., Cootes, T.: Automated scoring of aortic calcification in vertebral fracture assessment images. In: Medical Imaging 2019: Computer-Aided Diagnosis, vol. 10950, pp. 811–819. SPIE (2019)
Elmasri, K., Hicks, Y., Yang, X., Sun, X., Pettit, R., Evans, W.: Automatic detection and quantification of abdominal aortic calcification in dual energy X-ray absorptiometry. Proc. Comput. Sci. 96, 1011–1021 (2016)
He, K., Zhang, X., Ren, S., Sun, J.: Identity mappings in deep residual networks. In: Leibe, B., Matas, J., Sebe, N., Welling, M. (eds.) ECCV 2016. LNCS, vol. 9908, pp. 630–645. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46493-0_38
Kauppila, L.I., Polak, J.F., Cupples, L.A., Hannan, M.T., Kiel, D.P., Wilson, P.W.: New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 132(2), 245–250 (1997)
Kingma, D.P., Ba, J.: Adam: a method for stochastic optimization. arXiv preprint arXiv:1412.6980 (2014)
Leow, K., et al.: Prognostic value of abdominal aortic calcification: a systematic review and meta-analysis of observational studies. J. Am. Heart Assoc. 10(2), e017205 (2021)
Lewis, J.R., et al.: Association between abdominal aortic calcification, bone mineral density, and fracture in older women. J. Bone Miner. Res. 34(11), 2052–2060 (2019)
Lewis, J.R., et al.: Long-term atherosclerotic vascular disease risk and prognosis in elderly women with abdominal aortic calcification on lateral spine images captured during bone density testing: a prospective study. J. Bone Miner. Res. 33(6), 1001–1010 (2018)
Lewis, J.R., et al.: Abdominal aortic calcification identified on lateral spine images from bone densitometers are a marker of generalized atherosclerosis in elderly women. Arterioscler. Thromb. Vasc. Biol. 36(1), 166–173 (2016)
Lillemark, L., Ganz, M., Barascuk, N., Dam, E.B., Nielsen, M.: Growth patterns of abdominal atherosclerotic calcified deposits from lumbar lateral x-rays. Int. J. Cardiovasc. Imaging 26(7), 751–761 (2010)
Pickhardt, P.J., et al.: Automated CT biomarkers for opportunistic prediction of future cardiovascular events and mortality in an asymptomatic screening population: a retrospective cohort study. Lancet Digit. Health 2(4), e192–e200 (2020)
Radavelli-Bagatini, S., et al.: Modification of diet, exercise and lifestyle (model) study: a randomised controlled trial protocol. BMJ Open 10(11), e036366 (2020)
Reid, S., Schousboe, J.T., Kimelman, D., Monchka, B.A., Jozani, M.J., Leslie, W.D.: Machine learning for automated abdominal aortic calcification scoring of DXA vertebral fracture assessment images: a pilot study. Bone 148, 115943 (2021)
Roth, G.A., et al.: Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J. Am. Coll. Cardiol. 76(25), 2982–3021 (2020)
Schousboe, J.T., Lewis, J.R., Kiel, D.P.: Abdominal aortic calcification on dual-energy X-ray absorptiometry: methods of assessment and clinical significance. Bone 104, 91–100 (2017)
Schousboe, J.T., Taylor, B.C., Kiel, D.P., Ensrud, K.E., Wilson, K.E., McCloskey, E.V.: Abdominal aortic calcification detected on lateral spine images from a bone densitometer predicts incident myocardial infarction or stroke in older women. J. Bone Miner. Res. 23(3), 409–416 (2008)
Schousboe, J.T., Wilson, K.E., Kiel, D.P.: Detection of abdominal aortic calcification with lateral spine imaging using DXA. J. Clin. Densitom. 9(3), 302–308 (2006)
Srivastava, N., Hinton, G., Krizhevsky, A., Sutskever, I., Salakhutdinov, R.: Dropout: a simple way to prevent neural networks from overfitting. J. Mach. Learn. Res. 15(1), 1929–1958 (2014)
Strong, J.P., et al.: Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the pathobiological determinants of atherosclerosis in youth study. Jama 281(8), 727–735 (1999)
Acknowledgement
The work was funded by a National Health and Medical Research Council (NH &MRC) of Australia Ideas grants (APP1183570). The salary of JRL is supported by a National Heart Foundation of Australia Future Leader Fellowship (ID: 102817). The study was approved by the Health Research Ethics Board for the University of Manitoba (HREB H2004:017L, HS20121). The Manitoba Health Information Privacy Committee approved access to the Manitoba data (HIPC 2016/2017-29). The results and conclusions are those of the authors and no official endorsement by Manitoba Health and Seniors Care, or other data providers is intended or should be inferred.
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Gilani, S.Z. et al. (2022). Show, Attend and Detect: Towards Fine-Grained Assessment of Abdominal Aortic Calcification on Vertebral Fracture Assessment Scans. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2022. MICCAI 2022. Lecture Notes in Computer Science, vol 13433. Springer, Cham. https://doi.org/10.1007/978-3-031-16437-8_42
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