Abstract
Myopic Maculopathy is the leading cause of legal blindness in patients with pathologic myopia. Automated myopic maculopathy diagnosis is of vital importance to early treatment and progression slowdown. However, the scarcity of labeled fundus images with myopic maculopathy makes it challenging to improve diagnostic performance via deep learning models. In this paper, we construct a label-efficient deep learning framework for myopic maculopathy classification. In specific, we exploit two categories of pre-training methods, i.e., vision-language pre-training and self-supervised visual representation learning, to alleviate the overfitting problem caused by the limited number of training images. Moreover, we adopt a semi-supervised learning technique, namely pseudo labeling, to leverage a large number of unlabeled fundus images from external datasets. We also investigate the impact of other key components in model training for better performance, including backbone architecture, input resolution, and loss function. Our method is evaluated in the MICCAI 2023 Myopic Maculopathy Analysis Challenge (MMAC). Among 17 participating teams, our ensembled model ranked 1st on the leaderboard with an average score of 0.8752. The code will be publicly available at https://github.com/FDU-VTS/MMAC.
This work was supported by the National Natural Science Foundation of China (No. 62172101), Chinese National Key Research and Development Program (No. 2021YFC2702100), the Science and Technology Commission of Shanghai Municipality (No. 21511104502).
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References
Burlina, P., Freund, D.E., Joshi, N., Wolfson, Y., Bressler, N.M.: Detection of age-related macular degeneration via deep learning. In: 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), pp. 184–188. IEEE (2016)
Cai, Z., Lin, L., He, H., Tang, X.: Uni4Eye: unified 2d and 3d self-supervised pre-training via masked image modeling transformer for ophthalmic image classification. In: Wang, L., Dou, Q., Fletcher, P.T., Speidel, S., Li, S. (eds.) Medical Image Computing and Computer Assisted Intervention - MICCAI 2022. MICCAI 2022, LNCS, vol. 13438, pp. 88–98. Springer, Cham (2022). https://doi.org/10.1007/978-3-031-16452-1_9
Dai, L., et al.: A deep learning system for detecting diabetic retinopathy across the disease spectrum. Nat. Commun. 12(1), 3242 (2021)
Dosovitskiy, A., et al.: An image is worth 16x16 words: transformers for image recognition at scale. arXiv preprint arXiv:2010.11929 (2020)
Fu, H., et al.: Disc-aware ensemble network for glaucoma screening from fundus image. IEEE Trans. Med. Imaging 37(11), 2493–2501 (2018)
Gulshan, V., et al.: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. Jama 316(22), 2402–2410 (2016)
He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)
Hou, J., et al.: Diabetic retinopathy grading with weakly-supervised lesion priors. In: ICASSP 2023–2023 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), pp. 1–5. IEEE (2023)
Hou, J., Xiao, F., Xu, J., Zhang, Y., Zou, H., Feng, R.: Deep-OCTA: ensemble deep learning approaches for diabetic retinopathy analysis on OCTA images. In: Sheng, B., Aubreville, M. (eds.) Mitosis Domain Generalization and Diabetic Retinopathy Analysis. MIDOG DRAC 2022 2022. LNCS, vol. 13597, pp. 74–87. Springer, Cham (2023). https://doi.org/10.1007/978-3-031-33658-4_8
Hou, J., et al.: Cross-field transformer for diabetic retinopathy grading on two-field fundus images. In: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), pp. 985–990. IEEE (2022)
Howard, A.G., et al.: Mobilenets: efficient convolutional neural networks for mobile vision applications. arXiv preprint arXiv:1704.04861 (2017)
Huang, Y., Lin, L., Cheng, P., Lyu, J., Tang, X.: Lesion-based contrastive learning for diabetic retinopathy grading from fundus images. In: de Bruijne, M., et al. Medical Image Computing and Computer Assisted Intervention - MICCAI 2021, MICCAI 2021, LNCS, Part II, vol. 12902, pp. 113–123. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-87196-3_11
Li, T., Gao, Y., Wang, K., Guo, S., Liu, H., Kang, H.: Diagnostic assessment of deep learning algorithms for diabetic retinopathy screening. Inf. Sci. 501, 511–522 (2019)
Li, X., et al.: Rotation-oriented collaborative self-supervised learning for retinal disease diagnosis. IEEE Trans. Med. Imaging 40(9), 2284–2294 (2021)
Li, X., Jia, M., Islam, M.T., Yu, L., Xing, L.: Self-supervised feature learning via exploiting multi-modal data for retinal disease diagnosis. IEEE Trans. Med. Imaging 39(12), 4023–4033 (2020)
Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollár, P.: Focal loss for dense object detection. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2980–2988 (2017)
Lin, W., et al.: Pmc-clip: contrastive language-image pre-training using biomedical documents. arXiv preprint arXiv:2303.07240 (2023)
Liu, R., et al.: DeepDRiD: diabetic retinopathy-grading and image quality estimation challenge. Patterns 3(6), 100512 (2022)
Ohno-Matsui, K., et al.: International photographic classification and grading system for myopic maculopathy. Am. J. Ophthalmol. 159(5), 877–883 (2015)
Radford, A., et al.: Learning transferable visual models from natural language supervision. In: International Conference on Machine Learning, pp. 8748–8763. PMLR (2021)
Ruiz-Medrano, J., Montero, J.A., Flores-Moreno, I., Arias, L., GarcÃa-Layana, A., Ruiz-Moreno, J.M.: Myopic maculopathy: current status and proposal for a new classification and grading system (ATN). Prog. Retin. Eye Res. 69, 80–115 (2019)
Sun, Y., Li, Y., Zhang, F., Zhao, H., Liu, H., Wang, N., Li, H.: A deep network using coarse clinical prior for myopic maculopathy grading. Comput. Biol. Med. 154, 106556 (2023)
Tan, M., Le, Q.: EfficientNet: rethinking model scaling for convolutional neural networks. In: International Conference on Machine Learning, pp. 6105–6114. PMLR (2019)
Wang, R., et al.: Efficacy of a deep learning system for screening myopic maculopathy based on color fundus photographs. Ophthalmol Ther. 12(1), 469–484 (2023)
Xue, W., et al.: Deep learning-based analysis of infrared fundus photography for automated diagnosis of diabetic retinopathy with cataracts. J. Cataract Refract. Surg. 49(10), 1043–1048 (2023)
Zhang, K., et al.: BiomedGPT: a unified and generalist biomedical generative pre-trained transformer for vision, language, and multimodal tasks. arXiv preprint arXiv:2305.17100 (2023)
Zhang, S., et al.: Large-scale domain-specific pretraining for biomedical vision-language processing. arXiv preprint arXiv:2303.00915 (2023)
Zhao, R., Liao, W., Zou, B., Chen, Z., Li, S.: Weakly-supervised simultaneous evidence identification and segmentation for automated glaucoma diagnosis. In: Proceedings of the AAAI Conference on Artificial Intelligence, vol. 33, pp. 809–816 (2019)
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Hou, J. et al. (2024). Towards Label-Efficient Deep Learning for Myopic Maculopathy Classification. In: Sheng, B., Chen, H., Wong, T.Y. (eds) Myopic Maculopathy Analysis. MICCAI 2023. Lecture Notes in Computer Science, vol 14563. Springer, Cham. https://doi.org/10.1007/978-3-031-54857-4_3
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