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Zoomable Heatmaps: Improving Manhattan Plots to Compare Multiple Genome-Wide Studies

  • Conference paper
  • First Online:
Design for Equality and Justice (INTERACT 2023)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 14536))

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Abstract

Making comparisons between genome-wide association studies is a crucial practice in genetics. Despite this, conventional visualizations used in these studies tend to suffer from readability issues. These issues include, for instance, overcrowded data points and difficulties in supporting comparisons between different distributions. One of the most commonly used visualizations for this purpose, the traditional Manhattan plot, is visually optimized for comparing peaks only within one distribution of data points. In genetics research, however, there is often a need to compare multiple distributions. In this paper, we present a novel interaction model that relies on the use of zoomable heatmaps. This interaction model aims to support users in preliminary and straightforward cross-distribution comparisons through semantic zooming, heatmaps, and the overview+detail approach. All these interaction methods have their origin in map-based user interfaces and visualizations.

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Notes

  1. 1.

    MMP is available at https://geneviz.aalto.fi/MMP/2023/.

  2. 2.

    https://www.finngen.fi/en.

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Authors and Affiliations

  1. School of Arts, Design and Architecture, Aalto University, Espoo, Finland

    Fe Simeoni, Nicola Cerioli, Rupesh Vyas & Masood Masoodian

  2. Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland

    Fe Simeoni, Mark Daly & Mary Pat Reeve

Authors
  1. Fe Simeoni
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  2. Nicola Cerioli
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  3. Mark Daly
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  4. Mary Pat Reeve
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  5. Rupesh Vyas
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  6. Masood Masoodian
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Corresponding author

Correspondence to Fe Simeoni .

Editor information

Editors and Affiliations

  1. University of York, York, UK

    Anna Bramwell-Dicks

  2. University of York, York, UK

    Abigail Evans

  3. Université Côte d‘Azur, Sophia Antipolis, France

    Marco Winckler

  4. University of York, York, UK

    Helen Petrie

  5. University of West London, London, UK

    José Abdelnour-Nocera

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Simeoni, F., Cerioli, N., Daly, M., Reeve, M.P., Vyas, R., Masoodian, M. (2024). Zoomable Heatmaps: Improving Manhattan Plots to Compare Multiple Genome-Wide Studies. In: Bramwell-Dicks, A., Evans, A., Winckler, M., Petrie, H., Abdelnour-Nocera, J. (eds) Design for Equality and Justice. INTERACT 2023. Lecture Notes in Computer Science, vol 14536. Springer, Cham. https://doi.org/10.1007/978-3-031-61698-3_14

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  • DOI: https://doi.org/10.1007/978-3-031-61698-3_14

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  • Online ISBN: 978-3-031-61698-3

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