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Treatment Planning for Electrochemotherapy and Irreversible Electroporation of Deep-Seated Tumors

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Handbook of Electroporation

Abstract

Electrochemotherapy and irreversible electroporation can be used to treat deep-seated tumors. Key to treatment success is ensuring that the entirety of the target tumor is covered with electric fields of sufficient strength during the treatment. Treatment planning using numerical methods has long been established in radiotherapy, and this chapter presents the necessary tools to realize a similar treatment planning framework also for electrochemotherapy and irreversible electroporation. Treatment planning consists of identifying the target tumor and surrounding tissues on tomographic medical images. This reconstruction can be used to build a numerical model of the region of interest with by assigning correct conductivities to each tissue in the treatment zone. Using the finite element method, electric fields for a given electrode configuration can be determined. By coupling the numerical model of electroporation with appropriate optimization algorithms, the voltage to be delivered to each electrode pair can be determined and the positions of electrodes can be adjusted to ensure successful coverage of the target volume. Possible approaches to execute the treatment according to the prepared treatment plan are also discussed at the end of the chapter.

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Authors and Affiliations

  1. Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, SI-1000, Ljubljana, Slovenia

    Bor Kos

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  1. Bor Kos
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Correspondence to Bor Kos .

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Editors and Affiliations

  1. Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia

    Damijan Miklavčič

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Kos, B. (2017). Treatment Planning for Electrochemotherapy and Irreversible Electroporation of Deep-Seated Tumors. In: Miklavčič, D. (eds) Handbook of Electroporation. Springer, Cham. https://doi.org/10.1007/978-3-319-32886-7_2

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