Abstract
Detection and analysis of the arterio-venular tree of the retina is a relevant issue, providing useful information in procedures such as the diagnosis of different pathologies. Classical approaches for vessel extraction make use of 2D acquisition paradigms and, therefore, obtain a limited representation of the vascular structure. This paper proposes a new methodology for the automatic 3D segmentation and reconstruction of the retinal arterio-venular tree in Optical Coherence Tomography (OCT) images. The methodology takes advantage of different image analysis techniques to initially segment the vessel tree and estimate its calibers along it. Then, the corresponding depth for the entire vessel tree is obtained. Finally, with all this information, the method performs the 3D reconstruction of the entire vessel tree.
The test and validation procedure employed 196 OCT histological images with the corresponding near infrared reflectance retinographies. The methodology showed promising results, demonstrating its accuracy in a complex domain, providing a coherent 3D vessel tree reconstruction that can be posteriorly analyzed in different medical diagnostic processes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Klein, R., Klein, B., Moss, S., et al.: Retinal vascular caliber in persons with type 2 diabetes: the Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. Ophthalmol. J. 113(9), 1488–1498 (2006)
Smith, W., Wang, J.J., Wong, T.Y., et al.: Retinal arteriolar narrowing is associated with 5-year incident severe hypertension: The blue mountains eye study. Hypertens. J. 44(4), 442–447 (2004)
De Jong, F.J., Ikram, M.K., Witteman, J.C., et al.: Retinal vessel diameters and the role of inflammation in cerebrovascular disease. Ann. Neurol. J. 61(5), 491–495 (2007)
Sun, C., Liew, G., Wang, J.J., et al.: Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore malay eye study. Invest. Ophthalmol. Vis. Sci. J. 49(5), 1784–1790 (2008)
Wong, T.Y.: Quantitative retinal venular caliber and risk of cardiovascular disease in older persons. Arch. Intern. Med. J. 166(21), 2388–2394 (2006)
Ortega, M., Penedo, M.G., Rouco, J., et al.: Personal verification based on extraction and characterisation of retinal feature points. J. Vis. Lang. Comput. 20(2), 80–90 (2009)
Yong, Y., Yuan, Z., Shuying, H., et al.: Effective combined algorithms for retinal blood vessels extraction. Adv. Inf. Sci. Serv. Sci. J. 4(3), 263–269 (2012)
Xiaolin, S., Zhenhua, C., Chuang, M., et al.: Retinal vessel tracking using bilateral filter based on canny method. In: International Conference on Audio, Language and Image Processing, pp. 1678–1682 (2010)
Mendonça, A.M., Campilho, A.: Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction. IEEE Trans. Med. Imag. 25(9), 1200–1213 (2006)
Nayak, C.: Retinal blood vessel segmentation algorithm for diabetic retinopathy using wavelet: a survey. Int. J. Recent Innovation Trends Comput. Commun. 3(3), 927–930 (2013)
Chen, X., Niemeijer, M., Zhang, L., et al.: Three-dimensional segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search-graph-cut. IEEE Trans. Med. Imag. 31(8), 1521–1531 (2012)
Ding, C., Xia, Y., Li, Y.: Supervised Segmentation of Vasculature in Retinal Images Using Neural Networks. In: IEEE International Conference on Orange Technologies, pp. 49–52 (2014)
Guimaraes, P., Rodrigues, P., Bernardes, R., Serranho, P.: 3D blood vessels segmentation from optical coherence tomography. Acta Ophthalmologica 90 (2012). doi:10.1111/j.1755-3768.2012.2712.x
Pilch, M., Wenner, Y., Strohmayr, E., et al.: Automated segmentation of retinal blood vessels in spectral domain optical coherence tomography scans. Biomed. Opt. Express 3(7), 1478–1491 (2012)
Wu, J., Gerendas, B., Waldstein, S., et al.: Stable registration of pathological 3D-OCT scans using retinal vessels. In: Proceedings of the Ophthalmic Medical Image Analysis First International Workshop, OMIA 2014, Held in Conjunction with MICCAI 2014, pp. 1–8 (2014)
Calvo, D., Ortega, M., Penedo, M.G., Rouco, J.: Automatic detection and characterisation of retinal vessel tree bifurcations and crossovers in eye fundus images. Comput. Methods Programs Biomed. 103, 28–38 (2011)
Acknowledgments
This work is supported by the Instituto de Salud Carlos III of the Spanish Government and FEDER funds of the European Union through thePI14/02161 and theDTS15/00153 research projects.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this paper
Cite this paper
de Moura, J., Novo, J., Ortega, M., Charlón, P. (2016). 3D Retinal Vessel Tree Segmentation and Reconstruction with OCT Images. In: Campilho, A., Karray, F. (eds) Image Analysis and Recognition. ICIAR 2016. Lecture Notes in Computer Science(), vol 9730. Springer, Cham. https://doi.org/10.1007/978-3-319-41501-7_80
Download citation
DOI: https://doi.org/10.1007/978-3-319-41501-7_80
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-41500-0
Online ISBN: 978-3-319-41501-7
eBook Packages: Computer ScienceComputer Science (R0)