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On Approximating an Implicit Cover Problem in Biology

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Algorithmic Aspects in Information and Management (AAIM 2009)

Abstract

In an implicit combinatorial optimization problem, the constraints are not enumerated explicitly but rather stated implicitly through equations, other constraints or auxiliary algorithms. An important subclass of such problems is the implicit set cover (or, equivalently, hitting set) problem in which the sets are not given explicitly but rather defined implicitly. For example, the well-known minimum feedback arc set problem is such a problem. In this paper, we consider such a cover problem that arises in the study of wild populations in biology in which the sets are defined implicitly via the Mendelian constraints and prove approximability results for this problem.

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References

  1. Almudevar, A.: A simulated annealing algorithm for maximum likelihood pedigree reconstruction. Theoretical Population Biology 63, 63–75 (2003)

    Article  MATH  Google Scholar 

  2. Almudevar, A., Field, C.: Estimation of single generation sibling relationships based on DNA markers. Journal of Agricultural, Biological, and Environmental Statistics 4, 136–165 (1999)

    Article  MathSciNet  Google Scholar 

  3. Arora, S., Lund, C.: Hardness of Approximations. In: Hochbaum, D. (ed.) Approximation Algorithms for NP-hard Problems. PWS Publishing (1996)

    Google Scholar 

  4. Arora, S., Lund, C., Motwani, R., Sudan, M., Szegedy, M.: Proof verification and hardness of approximation problems. Journal of the ACM 45(3), 501–555 (1998)

    Article  MATH  MathSciNet  Google Scholar 

  5. Ashley, M.V., Caballero, I.C., Chaovalitwongse, W., DasGupta, B., Govindan, P., Sheikh, S., Berger-Wolf, T.Y.: KINALYZER, A Computer Program for Reconstructing Sibling Groups, to appear in Molecular Ecology Resources

    Google Scholar 

  6. Ashley, M., Berger-Wolf, T., Berman, P., Chaovalitwongse, W., DasGupta, B., Kao, M.-Y.: On Approximating Four Covering/Packing Problems. To appear in Journal of Computer and System Sciences

    Google Scholar 

  7. Berger-Wolf, T.Y., DasGupta, B., Chaovalitwongse, W., Ashley, M.V.: Combinatorial reconstruction of sibling relationships. In: Proceedings of the 6th International Symposium on Computational Biology and Genome Informatics, pp. 1252–1255 (2005)

    Google Scholar 

  8. Berger-Wolf, T.Y., Sheikh, S., DasGupta, B., Ashley, M.V., Caballero, I., Chaovalitwongse, W., Putrevu, S.L.: Reconstructing Sibling Relationships in Wild Populations. Bioinformatics (special issue of ISMB 2007) 23(13), i49–i56 (2007)

    Google Scholar 

  9. Beyer, J., May, B.: A graph-theoretic approach to the partition of individuals into full-sib families. Molecular Ecology 12, 2243–2250 (2003)

    Article  Google Scholar 

  10. Blouin, M.S.: DNA-based methods for pedigree reconstruction and kinship analysis in natural populations. TRENDS in Ecology and Evolution 18(10), 503–511 (2003)

    Article  Google Scholar 

  11. Butler, K., Field, C., Herbinger, C., Smith, B.: Accuracy, efficiency and robustness of four algorithms allowing full sibship reconstruction from DNA marker data. Molecular Ecology 13, 1589–1600 (2004)

    Article  Google Scholar 

  12. Caprara, A., Rizzi, R.: Packing Triangles in Bounded Degree Graphs. Information Processing Letters 84(4), 175–180 (2002)

    Article  MATH  MathSciNet  Google Scholar 

  13. Chaovalitwongse, W., Berger-Wolf, T.Y., DasGupta, B., Ashley, M.V.: Set covering approach for reconstruction of sibling relationships. Optimization Methods and Software 22(1), 11–24 (2007)

    Article  MATH  MathSciNet  Google Scholar 

  14. Chaovalitwongse, W., Chou, C.-A., Berger-Wolf, T., DasGupta, B., Sheikh, S., Ashley, M., Caballero, I.: New Optimization Model and Algorithm for Sibling Reconstruction from Genetic Markers. To appear in INFORMS Journal of Computing

    Google Scholar 

  15. Feige, U.: A threshold for approximating set cover. JACM 45, 634–652 (1998)

    Article  MATH  MathSciNet  Google Scholar 

  16. Feige, U., Lovasz, L.: Two-prover one-round proof systems: their power and their problems. In: Proc. 24th annual ACM symposium on Theory of computing, pp. 733–744 (1992)

    Google Scholar 

  17. Jones, A.G., Ardren, W.R.: Methods of parentage analysis in natural populations. Molecular Ecology (12), 2511–2523 (2003)

    Article  Google Scholar 

  18. Konovalov, D.A., Manning, C., Henshaw, M.T.: KINGROUP: a program for pedigree relationship reconstruction and kin group assignments using genetic markers. Molecular Ecology Notes, doi: 10.1111/j.1471-8286.2004.00796.x

    Google Scholar 

  19. Kortsarz, G., Krauthgamer, R., Lee, J.R.: Hardness of Approximating Vertex-Connectivity Network Design Problems. SIAM J. of Computing 33(3), 704–720 (2004)

    Article  MATH  Google Scholar 

  20. Painter, I.: Sibship reconstruction without parental information. Journal of Agricultural, Biological, and Environmental Statistics 2, 212–229 (1997)

    Article  MathSciNet  Google Scholar 

  21. Papadimitriou, C.H., Yannakakis, M.: Optimization, approximation, and complexity classes. Journal of Computer and System Sciences 43(3), 425–440 (1991)

    Article  MATH  MathSciNet  Google Scholar 

  22. Raz, R.: A parallel repetition theorem. SIAM J. of Computing 27(3), 763–803 (1998)

    Article  MATH  MathSciNet  Google Scholar 

  23. Sheikh, S.I., Berger-Wolf, T.Y., Ashley, M.V., Caballero, I.C., Chaovalitwongse, W., DasGupta, B.: Error Tolerant Sibship Reconstruction in Wild Populations. In: Markstein, P., Xu, Y. (eds.) Computational Systems Bioinformatics, pp. 273–284. World Scientific Publishers, Singapore (2008)

    Chapter  Google Scholar 

  24. Sheikh, S.I., Berger-Wolf, T.Y., Khokhar, A.A., DasGupta, B.: Consensus Methods for Reconstruction of Sibling Relationships from Genetic Data. In: 4th Multidisciplinary Workshop on Advances in Preference Handling, Chicago, IL (2008)

    Google Scholar 

  25. Smith, B.R., Herbinger, C.M., Merry, H.R.: Accurate partition of individuals into full-sib families from genetic data without parental information. Genetics 158, 1329–1338 (2001)

    Google Scholar 

  26. Thomas, S.C., Hill, W.G.: Sibship reconstruction in hierarchical population structures using markov chain monte carlo techniques. Genet. Res., Camb. 79, 227–234 (2002)

    Article  Google Scholar 

  27. Vazirani, V.: Approximation Algorithms. Springer, Heidelberg (2001)

    MATH  Google Scholar 

  28. Wang, J.: Sibship reconstruction from genetic data with typing errors. Genetics 166, 1968–1979 (2004)

    Google Scholar 

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Ashley, M.V., Berger-Wolf, T.Y., Chaovalitwongse, W., DasGupta, B., Khokhar, A., Sheikh, S. (2009). On Approximating an Implicit Cover Problem in Biology. In: Goldberg, A.V., Zhou, Y. (eds) Algorithmic Aspects in Information and Management. AAIM 2009. Lecture Notes in Computer Science, vol 5564. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02158-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-02158-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02157-2

  • Online ISBN: 978-3-642-02158-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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