Abstract
We have developed a network model of cerebellar cortex, in which granular cells’ activities represent a passage of time from the onset of a conditioned stimulus (CS). Long-term depression of parallel fiber synapses at Purkinje cells (PCs) encodes an interstimulus interval between onsets of a CS and an unconditioned stimulus (US) as cessation of PC firing, resulting in the emission of a conditioned response (CR) from cerebellar nucleus neurons. In this study, we show that a change in the strength of a CS extends or compresses spike trains of granule cells in the time dimension, suggesting controllability of CR timings flexibly after conditioning. Because PCs alone are insufficient to read out a modified interstimulus interval, we add stellate cells (SCs) inhibiting PCs. Thereby, after conditioning, PCs are shown to stop firing earlier or later than the US timing for a CS stronger or weaker than the CS during conditioning.
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Honda, T., Yamazaki, T., Tanaka, S., Nishino, T. (2010). A Possible Mechanism for Controlling Timing Representation in the Cerebellar Cortex. In: Zhang, L., Lu, BL., Kwok, J. (eds) Advances in Neural Networks - ISNN 2010. ISNN 2010. Lecture Notes in Computer Science, vol 6063. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13278-0_10
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DOI: https://doi.org/10.1007/978-3-642-13278-0_10
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