Abstract
The paper is concerned with modeling cancer growth, metastasis and response to anticancer treatment in a heterogeneous population of patients. Following a discussion of existing models, multicompartmental models are compared using Kaplan-Meier survival curves. Subsequently, different death conditions are analyzed, leading to the final conclusion that a simple, two-compartmental model describes primary and metastatic tumors well enough but death condition must fine-tuned to available clinical survival curves.
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This work has been supported by the NCN grant DEC-2020/37/B/ST6/01959.
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Smieja, J., Swierniak, A., Kimmel, M. (2022). A Minimal Model of Cancer Growth, Metastasis and Treatment. In: Szczerbicki, E., Wojtkiewicz, K., Nguyen, S.V., Pietranik, M., Krótkiewicz, M. (eds) Recent Challenges in Intelligent Information and Database Systems. ACIIDS 2022. Communications in Computer and Information Science, vol 1716. Springer, Singapore. https://doi.org/10.1007/978-981-19-8234-7_44
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