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Design of potential angiogenin inhibitors

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Summary

A model of angiogenin has been prepared by homology modelling, based upon the structure of ribonuclease A. This model has been used to postulate an inhibitor based upon the angiostatic agent TAN1120. The complex of ribonuclease A with a dinucleotide has been modelled and used as a guide to the binding orientation of daunomycin—the closest TAN1120 analogue for which the crystal structure and stereochemistry are available.

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Authors and Affiliations

  1. Department of Chemistry, University of Surrey, GU2 5XH, Guildford, Surrey, U.K.

    B. J. Howlia, N. P. Tomkinson, J. Chen & G. A. Webb

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  1. B. J. Howlia
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  2. N. P. Tomkinson
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  3. J. Chen
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  4. G. A. Webb
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Howlia, B.J., Tomkinson, N.P., Chen, J. et al. Design of potential angiogenin inhibitors. J Computer-Aided Mol Des 8, 223–230 (1994). https://doi.org/10.1007/BF00126741

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  • DOI: https://doi.org/10.1007/BF00126741

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