Abstract
Nonpolar methylene chloride-soluble extracts from the mycelia of Fusarium semitectum and Fusarium moniliforme var. subglutinans were toxic to Colorado potato beetles. The major toxic metabolite was isolated and found to be the cyclodepsipeptide, beauvericin. This is the first report of the isolation of beauvericin from the genus Fusarium.
Similar content being viewed by others
References
Vesonder RF, Golinski P. In: Chelkowski J, ed. Fusarium mycotoxins, taxonomy, and pathogenicity. New York: Elsevier, 1989: 1–39.
Chatterjee K, Pawlosky RJ, Mirocha CJ, Zhu T-X. Production of deepoxy-diacetoxyscirpenol in a culture of Fusarium graminearum. Appl Environ Microbiol 1986; 52: 311–3.
Gardner D, Glen AT, Turner WB. Calonectrin and 15-deacetylcalonectrin: new trichothecanes from Calonectria nivalis, J Chem Soc Perkin Trans I 1972; 2576–8.
Greenhalgh R, Levandier D, Adams W, Miller JD, Blackwell BA, McAlees AJ, Taylor A. Production and characterization of deoxynivalenol and other secondary metabolites of Fusarium culmorum. J Agric Food Chem 1986; 34: 98–102.
Stob M, Baldwin RS, Tuite J, Andrews FN, Gillette KG. Isolation of an anabolic, uterotrophic compound from corn infected with Gibberella zeae. Nature 1962; 196: 1318.
Bezuidenhout SC, Gelderblom WCA, Gorstallman CP, Horak RM, Marasas WFO, Spiteller G, Vleggaar R. Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme. J Chem Soc Chem Comm 1988: 743–5.
Cole RJ, Kirskey JW, Cutler HG, Doupnik BL, Peckham JC. Toxin from Fusarium moniliforme: effects on plants and animals. Science 1973; 179: 1324–6.
Wiebe LA, Bjeldanes LF. Fusarin C, a mutagen from Fusarium moniliforme grown on corn. J Food Sci 1981; 46: 1424–6.
Hamill RL, Higgens CE, Boaz HE, Gorman M. The structure of beauvericin: a new depsipeptide antibiotic toxic to Anemia salina. Tetrahed Lett 1969: 4255–8.
Bernardini M, Carilli A, Pacioni G, Santurbano B. Isolation of beauvericin from Paecilomyces fumoso-roseus. Phytochemistry 1975; 14: 1865.
Deol BS, Ridley DD, Singh P. Isolation of cyclodepsipeptides from plant pathogenic fungi. Aust J Chem 1978; 31: 1397–9.
Prince RC, Crofts AR, Steinrauf LK. A comparison of beauvericin, enniatin, and valinomycin as calcium transporting agents in liposomes and chromatophores. Biochem Biophys Res Comm 1974; 59: 697–703.
Dorschner E, Lardy H. Specificity of ion transport induced by beauvericin. Antimicrob Agents Chemotherap 1968: 11–4.
Alain Vey MM, Quiot J-M, Vago C. Mise en evidence et étude de l'action d'une mycotoxin, la beauvericine, sur des cellules d'insectes cultivées in vitro. C R Acad Sc Paris 1973; Vol. 276 Series D: 2489–92.
Grove JF, Pople M. The insecticidal activity of beauvericin and the enniatin complex. Mycopathologia, 1980; 70: 103–5.
Ovchinnikov YA, Ivanov VT, Mikhaleva II. The synthesis and some properties of beauvericin. Tetrahed Lett 1971: 159–62.
Burmeister HR, Vesonder RF, Peterson RE, Costello CE. Production and purification of a peptide of Fusarium tricinctum that causes conidia of Penicillium to swell. Mycopathologia 1985; 91: 53–6.
Carr SA, Block E, Costello CE, Vesonder RF, Burmeister HR. Structure determination of a new cyclodepsipeptide antibiotic from Fusaria fungi. J Org Chem. 1985; 50: 2854–8.
Zocher R, Keller U, Kleinkauf H. Enniatin synthetase, a novel type of multifunctional enzyme catalyzing depsipeptide synthesis in Fusarium oxysporum. Biochemistry 1982; 21: 43–8.
Peeters H, Zocher R, Madry N, Oelrichs PB, Kleinkauf H, Kraepelin, G. Cell free synthesis of the depsipeptide beauvericin. J Antibiotics 1983; 36: 1762–6.
Ito T, Arai T, Ohashi Y, Sasada Y. Structure of fusariocin C, a cytotoxic metabolite from Fusarium moniliforme. Agric Biol Chem 1981; 45: 689–92.
Finney DJ. Probit analysis. Cambridge: Cambridge University Press, 1971.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gupta, S., Krasnoff, S.B., Underwood, N.L. et al. Isolation of beauvericin as an insect toxin from Fusarium semitectum and Fusarium moniliforme var. subglutinans . Mycopathologia 115, 185–189 (1991). https://doi.org/10.1007/BF00462223
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00462223