Abstract
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic factors for both ailments. These diseases share common pathogenetic mechanisms including inflammation, oxidative stress, and tissue remodelling. Current therapeutic approaches are limited by low efficacy and adverse effects. Consequentially, LC has a 5-year survival of < 20%, while COPD is incurable, underlining the necessity for innovative treatment strategies. Two promising emerging classes of therapy against these diseases include plant-derived molecules (phytoceuticals) and nucleic acid-based therapies. The clinical application of both is limited by issues including poor solubility, poor permeability, and, in the case of nucleic acids, susceptibility to enzymatic degradation, large size, and electrostatic charge density. Nanoparticle-based advanced drug delivery systems are currently being explored as flexible systems allowing to overcome these limitations. In this review, an updated summary of the most recent studies using nanoparticle-based advanced drug delivery systems to improve the delivery of nucleic acids and phytoceuticals for the treatment of LC and COPD is provided. This review highlights the enormous relevance of these delivery systems as tools that are set to facilitate the clinical application of novel categories of therapeutics with poor pharmacokinetic properties.
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Abbasi E, Aval SF, Akbarzadeh A, Milani M, Nasrabadi HT, Joo SW, Hanifehpour Y, Nejati-Koshki K, Pashaei-Asl R (2014) Dendrimers: synthesis, applications, and properties. Nanoscale Res Lett 9(1):247
Abd Elwakil MM, Mabrouk MT, Helmy MW, Abdelfattah EA, Khiste SK, Elkhodairy KA, Elzoghby AO (2018) Inhalable lactoferrin-chondroitin nanocomposites for combined delivery of doxorubicin and ellagic acid to lung carcinoma. Nanomedicine (Lond) 13(16):2015–2035
Abdelaziz HM, Elzoghby AO, Helmy MW, Samaha MW, Fang JY, Freag MS (2019) Liquid crystalline assembly for potential combinatorial chemo-herbal drug delivery to lung cancer cells. Int J Nanomedicine 14:499–517
Abd-Rabou AA, Edris AE (2022) Frankincense essential oil nanoemulsion specifically induces lung cancer apoptosis and inhibits survival pathways. Cancer Nanotechnol 13(1):22
AbouAitah K, Lojkowski W (2022) Nanomedicine as an emerging technology to foster application of essential oils to fight cancer. Pharmaceuticals (Basel) 15(7):793
Abu Rous F, Singhi EK, Sridhar A, Faisal MS, Desai A (2022) Lung cancer treatment advances in 2022. Cancer Invest 41(1):12–24
Achi IT, Sarbadhikary P, George BP, Abrahamse H (2022) Multi-target potential of berberine as an antineoplastic and antimetastatic agent: a special focus on lung cancer treatment. Cells 11(21):3433
Adlravan E, Sepideh J-R, Nejati K, Karimi MA, Mousazadeh H, Abbasi A, Dadashpour M (2021) Potential activity of free and PLGA/PEG nanoencapsulated nasturtium officinale extract in inducing cytotoxicity and apoptosis in human lung carcinoma A549 cells. J Drug Deliv Sci Technol 61:102256
Agusti A, Hurd S, Jones P, Fabbri LM, Martinez F, Vogelmeier C, Vestbo J, Rodriguez-Roisin R (2013) FAQs about the GOLD 2011 assessment proposal of COPD: a comparative analysis of four different cohorts. Eur Respir J 42(5):1391–1401
Ahmad MZ, Akhter S, Mallik N, Anwar M, Tabassum W, Ahmad FJ (2013) Application of decoy oligonucleotides as novel therapeutic strategy: a contemporary overview. Curr Drug Discov Technol 10(1):71–84
(AIHW), Australian Institute of Health and Welfare (2020) Chronic obstructive pulmonary disease (COPD). Webpage, 2022, from https://www.aihw.gov.au/reports/chronic-respiratory-conditions/copd/contents/about. Accessed 08/12/2022
Aimonen K, Suhonen S, Hartikainen M, Lopes VR, Norppa H, Ferraz N, Catalán J (2021) Role of surface chemistry in the in vitro lung response to nanofibrillated cellulose. Nanomaterials (Basel) 11(2):389
Alamil JMR, Xenaki D, Manandhar B, Paudel KR, Hansbro PM, Oliver BG, Chellappan DK, Dua K (2023) Agarwood oil nanoemulsion attenuates production of lipopolysaccharide (LPS)-induced proinflammatory cytokines, IL-6 and IL-8 in human bronchial epithelial cells. EXCLI J 22:681–685
Alamil JMR, Paudel KR, Chan Y, Xenaki D, Panneerselvam J, Singh SK, Gulati M, Jha NK, Kumar D, Prasher P, Gupta G, Malik R, Oliver BG, Hansbro PM, Dua K, Chellappan DK (2022) Rediscovering the therapeutic potential of agarwood in the management of chronic inflammatory diseases. Molecules 27(9):3038
Albano GD, Gagliardo RP, Montalbano AM, Profita M (2022) Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases. Antioxidants (Basel) 11(11):2237
Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA Jr, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Make B, Marchetti N, Martinez FJ, Madinger NE, McEvoy C, Niewoehner DE, Porsasz J, Price CS, Reilly J, Scanlon PD, Sciurba FC, Scharf SM, Washko GR, Woodruff PG, Anthonisen NR (2011) Azithromycin for prevention of exacerbations of COPD. N Engl J Med 365(8):689–698
Aldawsari HM, Alhakamy NA, Padder R, Husain M, Md S (2020) Preparation and characterization of chitosan coated PLGA nanoparticles of resveratrol: improved stability, antioxidant and apoptotic activities in H1299 lung cancer cells. Coatings 10(5):439
Al-Jipouri A, Almurisi SH, Al-Japairai K, Bakar LM, Doolaanea AA (2023) Liposomes or extracellular vesicles: a comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery. Polymers (Basel) 15(2):318
Alkilany AM, Murphy CJ (2010) Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanoparticle Res 12(7):2313–2333
Allam V, Paudel KR, Gupta G, Singh SK, Vishwas S, Gulati M, Gupta S, Chaitanya M, Jha NK, Gupta PK, Patel VK, Liu G, Kamal MA, Hansbro PM, Oliver BGG, Chellappan DK, Dua K (2022) Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma. Environ Sci Pollut Res Int 29(42):62733–62754
Allen TM, Cullis PR (2004) Drug delivery systems: entering the mainstream. Science 303(5665):1818–1822
Alnuqaydan AM, Almutary AG, Azam M, Manandhar B, De Rubis G, Madheswaran T, Paudel KR, Hansbro PM, Chellappan DK, Dua K (2022a) Phytantriol-based berberine-loaded liquid crystalline nanoparticles attenuate inflammation and oxidative stress in lipopolysaccharide-induced RAW264.7 macrophages. Nanomaterials (Basel) 12(23):4312
Alnuqaydan AM, Almutary AG, Azam M, Manandhar B, Yin GHS, Yen LL, Madheswaran T, Paudel KR, Hansbro PM, Chellappan DK, Dua K (2022b) Evaluation of the cytotoxic activity and anti-migratory effect of berberine-phytantriol liquid crystalline nanoparticle formulation on non-small-cell lung cancer in vitro. Pharmaceutics 14(6):1119
Alqahtani MS, Kazi M, Alsenaidy MA, Ahmad MZ (2021) Advances in oral drug delivery. Front Pharmacol 12:618411
Amani A, York P, Chrystyn H, Clark BJ (2010) Evaluation of a nanoemulsion-based formulation for respiratory delivery of budesonide by nebulizers. AAPS PharmSciTech 11(3):1147–1151
Amirsaadat S, Pilehvar-Soltanahmadi Y, Zarghami F, Alipour S, Ebrahimnezhad Z, Zarghami N (2017) Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells. Artif Cells Nanomed Biotechnol 45(8):1649–1656
Aqil F, Kausar H, Agrawal AK, Jeyabalan J, Kyakulaga AH, Munagala R, Gupta R (2016) Exosomal formulation enhances therapeutic response of celastrol against lung cancer. Exp Mol Pathol 101(1):12–21
Arbain NH, Salim N, Masoumi HRF, Wong TW, Basri M, Abdul Rahman MB (2019) In vitro evaluation of the inhalable quercetin loaded nanoemulsion for pulmonary delivery. Drug Deliv Transl Res 9(2):497–507
Aschner Y, Downey GP (2016) Transforming growth factor-β: master regulator of the respiratory system in health and disease. Am J Respir Cell Mol Biol 54(5):647–655
Ashique S, De Rubis G, Sirohi E, Mishra N, Rihan M, Garg A, Reyes RJ, Manandhar B, Bhatt S, Jha NK, Singh TG, Gupta G, Singh SK, Chellappan DK, Paudel KR, Hansbro PM, Oliver BG, Dua K (2022) Short chain fatty acids: fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases. Chem Biol Interact 368:110231
Aubier M, Roussos C (1985) Effect of theophylline on respiratory muscle function. Chest 88(2 Suppl):91s–97s
Australian Bureau of Statistics (2017) 3303.0 - Causes of Death, Australia, 2015. Webpage, 2022, from https://www.abs.gov.au/ausstats/abs@.nsf/Lookup/by%20Subject/3303.0~2015~Main%20Features~Lung%20cancer~10004. Accessed 09/12/2022
Bachelder EM, Beaudette TT, Broaders KE, Dashe J, Frechet JM (2008) Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications. J Am Chem Soc 130(32):10494–10495
Bachelder EM, Pino EN, Ainslie KM (2017) Acetalated dextran: a tunable and acid-labile biopolymer with facile synthesis and a range of applications. Chem Rev 117(3):1915–1926
Bakr AF, Shao P, Farag MA (2022) Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review. Phytomedicine 99:153999
Baptista B, Carapito R, Laroui N, Pichon C, Sousa F (2021) mRNA, a revolution in biomedicine. Pharmaceutics 13(12):2090
Barnes PJ (2004) Distribution of receptor targets in the lung. Proc Am Thorac Soc 1(4):345–351
Barnes PJ, Burney PG, Silverman EK, Celli BR, Vestbo J, Wedzicha JA, Wouters EF (2015) Chronic obstructive pulmonary disease. Nat Rev Dis Primers 1:15076
Bates M (2021) The mRNA revolution is coming. IEEE Pulse 12(6):2–5
Begines B, Ortiz T, Pérez-Aranda M, Martínez G, Merinero M, Argüelles-Arias F, Alcudia A (2020) Polymeric nanoparticles for drug delivery: recent developments and future prospects. Nanomaterials (Basel) 10(7):1403
Bharatwaj B, Mohammad AK, Dimovski R, Cassio FL, Bazito RC, Conti D, Fu Q, Reineke J, da Rocha SR (2015) Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium. Mol Pharm 12(3):826–838
Boehme SA, Franz-Bacon K, Ludka J, DiTirro DN, Ly TW, Bacon KB (2016) MAP3K19 is overexpressed in COPD and is a central mediator of cigarette smoke-induced pulmonary inflammation and lower airway destruction. PLoS One 11(12):e0167169
Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E (2017) Anti-inflammatory effect of anti-TNF-α siRNA cationic phosphorus dendrimer nanocomplexes administered intranasally in a murine acute lung injury model. Biomacromolecules 18(8):2379–2388
Bollmeier SG, Hartmann AP (2020) Management of chronic obstructive pulmonary disease: a review focusing on exacerbations. Am J Health Syst Pharm 77(4):259–268
Bradley JD, Hu C, Komaki RR, Masters GA, Blumenschein GR, Schild SE, Bogart JA, Forster KM, Magliocco AM, Kavadi VS, Narayan S, Iyengar P, Robinson CG, Wynn RB, Koprowski CD, Olson MR, Meng J, Paulus R, Curran WJ Jr, Choy H (2020) Long-term results of NRG oncology RTOG 0617: standard- versus high-dose chemoradiotherapy with or without cetuximab for unresectable stage III non-small-cell lung cancer. J Clin Oncol 38(7):706–714
Braun SR, McKenzie WN, Copeland C, Knight L, Ellersieck M (1989) A comparison of the effect of ipratropium and albuterol in the treatment of chronic obstructive airway disease. Arch Intern Med 149(3):544–547
Cai Z, Tchou-Wong KM, Rom WN (2011) NF-kappaB in lung tumorigenesis. Cancers (Basel) 3(4):4258–4268
Castro-Aceituno V, Abbai R, Moon SS, Ahn S, Mathiyalagan R, Kim YJ, Kim YJ, Yang DC (2017) Pleuropterus multiflorus (Hasuo) mediated straightforward eco-friendly synthesis of silver, gold nanoparticles and evaluation of their anti-cancer activity on A549 lung cancer cell line. Biomed Pharmacother 93:995–1003
Celli BR, Thomas NE, Anderson JA, Ferguson GT, Jenkins CR, Jones PW, Vestbo J, Knobil K, Yates JC, Calverley PM (2008) Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am J Respir Crit Care Med 178(4):332–338
Ceña V, Wang H, Zhao X, Guo C, Ren D, Zhao Y, Xiao W, Jiao W (2015) Aptamer-dendrimer bioconjugates for targeted delivery of miR-34a expressing plasmid and antitumor effects in non-small cell lung cancer cells. Plos One 10(9):e0139136
Chan Y, Mehta M, Paudel KR, Madheswaran T, Panneerselvam J, Gupta G, Su QP, Hansbro PM, MacLoughlin R, Dua K, Chellappan DK (2021) Versatility of liquid crystalline nanoparticles in inflammatory lung diseases. Nanomedicine (Lond) 16(18):1545–1548
Chang HB, Chen BH (2015) Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus. Int J Nanomedicine 10:5059–5080
Chellappan DK, Dharwal V, Paudel KR, Jha NK, MacLoughlin R, Oliver BG, Hansbro PM, Dua K (2021) Mitochondrial dysfunctions associated with chronic respiratory diseases and their targeted therapies: an update. Future Med Chem 13(15):1249–1251
Chellappan DK, Paudel KR, Tan NW, Cheong KS, Khoo SSQ, Seow SM, Chellian J, Candasamy M, Patel VK, Arora P, Singh PK, Singh SK, Gupta G, Oliver BG, Hansbro PM, Dua K (2022) Targeting the mitochondria in chronic respiratory diseases. Mitochondrion 67:15–37
Chen HQ, Wei JH, Yang JS, Zhang Z, Yang Y, Gao ZH, Sui C, Gong B (2012) Chemical constituents of agarwood originating from the endemic genus Aquilaria plants. Chem Biodivers 9(2):236–250
Chen BH, Hsieh CH, Tsai SY, Wang CY, Wang CC (2020) Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway. Sci Rep 10(1):5163
Chin LH, Hon CM, Chellappan DK, Chellian J, Madheswaran T, Zeeshan F, Awasthi R, Aljabali AA, Tambuwala MM, Dureja H, Negi P, Kapoor DN, Goyal R, Paudel KR, Satija S, Gupta G, Hsu A, Wark P, Mehta M, Wadhwa R, Hansbro PM, Dua K (2020) Molecular mechanisms of action of naringenin in chronic airway diseases. Eur J Pharmacol 879:173139
Cicero AF, Baggioni A (2016) Berberine and its role in chronic disease. Adv Exp Med Biol 928:27–45
Clarence DD, Paudel KR, Manandhar B, Singh SK, Devkota HP, Panneerselvam J, Gupta V, Chitranshi N, Verma N, Saad S, Gupta G, Hansbro PM, Oliver BG, Madheswaran T, Dua K, Chellappan DK (2022). Unravelling the therapeutic potential of nano-delivered functional foods in chronic respiratory diseases. Nutrients 14(18):3828
Cohen JA, Beaudette TT, Cohen JL, Broaders KE, Bachelder EM, Frechet JM (2010) Acetal-modified dextran microparticles with controlled degradation kinetics and surface functionality for gene delivery in phagocytic and non-phagocytic cells. Adv Mater 22(32):3593–3597
Cohen JL, Schubert S, Wich PR, Cui L, Cohen JA, Mynar JL, Frechet JM (2011) Acid-degradable cationic dextran particles for the delivery of siRNA therapeutics. Bioconjug Chem 22(6):1056–1065
Corrie L, Muzaffar-Ur-Rehman MD, Kukatil L, Manasa D, Shirisha A (2021) Antifibrotic drugs for COVID-19: from orphan drugs to blockbusters? Curr Respir Med Rev 17(1):8–12
Corrie L, Gulati M, Awasthi A, Vishwas S, Kaur J, Khursheed R, Kumar R, Kumar A, Imran M, Chellappan DK, Gupta G, de Jesus Andreoli T, Pinto A, Morris YE, Choonara J, Adams K. Dua, Singh SK (2022) Polysaccharide, fecal microbiota, and curcumin-based novel oral colon-targeted solid self-nanoemulsifying delivery system: formulation, characterization, and in-vitro anticancer evaluation. Mater Today Chem 26:101165
Corrie L, Gulati M, Awasthi A, Vishwas S, Kaur J, Khursheed R, Porwal O, Alam A, Parveen SR, Singh H, Chellappan DK, Gupta G, Kumbhar P, Disouza J, Patravale V, Adams J, Dua K, Singh SK (2022) Harnessing the dual role of polysaccharides in treating gastrointestinal diseases: as therapeutics and polymers for drug delivery. Chem Biol Interact 368:110238
Corrie L, Kaur J, Awasthi A, Vishwas S, Gulati M, Saini S, Kumar B, Pandey NK, Gupta G, Dureja H, Chellapan DK, Dua K, Tewari D, Singh SK (2022) Multivariate data analysis and central composite design-oriented optimization of solid carriers for formulation of curcumin-loaded solid SNEDDS: dissolution and bioavailability assessment. Pharmaceutics 14. https://doi.org/10.3390/pharmaceutics14112395
Crintea A, Dutu AG, Samasca G, Florian IA, Lupan I, Craciun AM (2021) The nanosystems involved in treating lung cancer. Life (Basel) 11(7):682
Cui Z, Ruan Z, Zeng J, Sun J, Ye W, Xu W, Guo X, Zhang L, Song L (2022) Lung-specific exosomes for co-delivery of CD47 blockade and cisplatin for the treatment of non-small cell lung cancer. Thorac Cancer 13(19):2723–2731
Cyril N, George JB, Joseph L, Raghavamenon AC, Sylas PV (2019) Assessment of antioxidant, antibacterial and anti-proliferative (lung cancer cell line A549) activities of green synthesized silver nanoparticles from Derris trifoliata. Toxicol Res (Camb) 8(2):297–308
Czarnecka-Chrebelska KH, Mukherjee D, Maryanchik SV, Rudzinska-Radecka M (2023) Biological and genetic mechanisms of COPD, its diagnosis, treatment, and relationship with lung cancer. Biomedicines 11(2):448
Dadashpour M, Firouzi-Amandi A, Pourhassan-Moghaddam M, Maleki MJ, Soozangar N, Jeddi F, Nouri M, Zarghami N, Pilehvar-Soltanahmadi Y (2018) Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells. Mater Sci Eng C Mater Biol Appl 92:902–912
Dahham SS, Tabana YM, Ahmed Hassan LE, Khadeer Ahamed MB, Abdul Majid AS, Abdul Majid AMS (2016) In vitro antimetastatic activity of Agarwood (Aquilaria crassna) essential oils against pancreatic cancer cells. Alex J Med 52(2):141–150
Dahham SS, Tabana YM, Ahamed MBK, Majid AMA (2015) In vivo anti-inflammatory activity of β-caryophyllene, evaluated by molecular imaging. Molecules & Medicinal Chemistry 1:e1001
Damase TR, Sukhovershin R, Boada C, Taraballi F, Pettigrew RI, Cooke JP (2021) The limitless future of RNA therapeutics. Front Bioeng Biotechnol 9:628137
Dang X, Yang L, Guo J, Hu H, Li F, Liu Y, Pang Y (2019) miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5. Chem Biol Interact 300:82–90
Darvin P, Chandrasekharan A, Santhosh Kumar TR (2019) Introduction to smart drug delivery systems. Biomimetic Nanoeng Mater Adv Drug Deliv 7:1261–1265
de França JOC, da Silva Valadares D, Paiva MF, Dias SCL, Dias JA (2022) Polymers based on PLA from synthesis using D,L-lactic acid (or racemic lactide) and some biomedical applications: a short review. Polymers (Basel) 14(12):2317
De Rubis G, Bebawy M (2021) Extracellular vesicles in chemoresistance. Subcell Biochem 97:211–245
De Rubis G, Paudel KR, Liu G, Agarwal V, MacLoughlin R, de Jesus Andreoli Pinto T, Singh SK, Adams J, Nammi S, Chellappan DK, Oliver BGG, Hansbro PM, Dua K (2023a) Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells. Toxicol In Vitro 92:105660
De Rubis G, Paudel KR, Manandhar B, Singh SK, Gupta G, Malik R, Shen J, Chami A, MacLoughlin R, Chellappan DK, Oliver BGG, Hansbro PM, Dua K (2023b) Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1.1 airway epithelial cells. Nutrients 15(4):1019
Dela Cruz CS, Tanoue LT, Matthay RA (2011) Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med 32(4):605–644
Devkota HP, Paudel KR, Hassan MM, Dirar AI, Das N, Adhikari-Devkota A, Echeverría J, Logesh R, Jha NK, Singh SK, Hansbro PM, Chan Y, Chellappan DK, Dua K (2021) Bioactive compounds from Zingiber montanum and their pharmacological activities with focus on Zerumbone. Appl Sci 11(21):10205
Devkota HP, Paudel KR, Jha NK, Gupta PK, Singh SK, Chellappan DK, Hansbro PM, Dua K (2021) Applications of drug-delivery systems targeting inflammasomes in pulmonary diseases. Nanomedicine (Lond) 16(27):2407–2410
Devkota HP, Adhikari-Devkota A, Paudel KR, Panth N, Gupta G, Chellappan DK, Hansbro PM, Dua K (2022) Phytochemicals and their nanoformulations targeted for pulmonary diseases. Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases. Chellappan DK, Pabreja K and Faiyazuddin M. Singapore, Springer Singapore: 95-106
Dhanapal J, Balaraman Ravindrran M (2018) Chitosan/poly (lactic acid)-coated piceatannol nanoparticles exert an in vitro apoptosis activity on liver, lung and breast cancer cell lines. Artif Cells Nanomed Biotechnol 46(sup1):274–282
Dhanjal DS, Sharma P, Mehta M, Tambuwala MM, Prasher P, Paudel KR, Liu G, Shukla SD, Hansbro PM, Chellappan DK, Dua K, Satija S (2022) Concepts of advanced therapeutic delivery systems for the management of remodeling and inflammation in airway diseases. Future Med Chem 14(4):271–288
Di Gioia S, Conese M (2009) Polyethylenimine-mediated gene delivery to the lung and therapeutic applications. Drug Des Devel Ther 2:163–188
Din FU, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, Zeb A (2017) Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine 12:7291–7309
Ding Y, Wang C, Wang Y, Xu Y, Zhao J, Gao M, Ding Y, Peng J, Li L (2018) Development and evaluation of a novel drug delivery: Soluplus(®)/TPGS mixed micelles loaded with piperine in vitro and in vivo. Drug Dev Ind Pharm 44(9):1409–1416
Dinh TD, Higuchi Y, Kawakami S, Yamashita F, Hashida M (2011) Evaluation of osteoclastogenesis via NFkappaB decoy/mannosylated cationic liposome-mediated inhibition of pro-inflammatory cytokine production from primary cultured macrophages. Pharm Res 28(4):742–751
Dong J, Liao W, Peh HY, Tan WSD, Zhou S, Wong WSF (2018) Ribosomal protein S3 gene silencing protects against cigarette smoke-induced acute lung injury. Mol Ther Nucleic Acids 12:370–380
Dong J, Liao W, Tan LH, Yong A, Peh WY, Wong WSF (2019) Gene silencing of receptor-interacting protein 2 protects against cigarette smoke-induced acute lung injury. Pharmacol Res 139:560–568
Dos Santos CF, Braz MG, de Arruda NM, Caram L, Nogueira DL, Tanni SE, de Godoy I, Ferrari R (2022) DNA damage and antioxidant capacity in COPD patients with and without lung cancer. PLoS One 17(11):e0275873
Du Y, Ding Y, Chen X, Mei Z, Ding H, Wu Y, Jie Z (2017) MicroRNA-181c inhibits cigarette smoke-induced chronic obstructive pulmonary disease by regulating CCN1 expression. Respir Res 18(1):155
Dua K, Malyla V, Singhvi G, Wadhwa R, Krishna RV, Shukla SD, Shastri MD, Chellappan DK, Maurya PK, Satija S, Mehta M, Gulati M, Hansbro N, Collet T, Awasthi R, Gupta G, Hsu A, Hansbro PM (2019) Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: an emerging need for novel drug delivery systems. Chem Biol Interact 299:168–178
Duska LR, Krasner CN, O’Malley DM, Hays JL, Modesitt SC, Mathews CA, Moore KN, Thaker PH, Miller A, Purdy C, Zamboni WC, Lucas AT, Supko JG, Schilder RJ (2021) A phase Ib/II and pharmacokinetic study of EP0057 (formerly CRLX101) in combination with weekly paclitaxel in patients with recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer. Gynecol Oncol 160(3):688–695
Etminan A, Neamati A, Balanezhad SZ, Etminan A (2022) Ultrasonic nano emulsification of apricot kernel oil and its therapeutics effects on suppression of human lung cancer cells (A549). Mater Technol 37(14):3231–3240
Farokhzad OC, Langer R (2009) Impact of nanotechnology on drug delivery. ACS Nano 3(1):16–20
Fazelifar P, Tabrizi MH, Rafiee A (2021) The Arachis hypogaea essential oil nanoemulsion as an efficient safe apoptosis inducer in human lung cancer cells (A549). Nutr Cancer 73(6):1059–1067
Feng Q, Xiao K (2022) Nanoparticle-mediated delivery of STAT3 inhibitors in the treatment of lung cancer. Pharmaceutics 14(12):2787
Fu L, Chen W, Guo W, Wang J, Tian Y, Shi D, Zhang X, Qiu H, Xiao X, Kang T, Huang W, Wang S, Deng W (2013) Berberine targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and cytochrome-c/caspase signaling to suppress human cancer cell growth. PLoS One 8(7):e69240
Gandek TB, van der Koog L, Nagelkerke A (2023) A comparison of cellular uptake mechanisms, delivery efficacy, and intracellular fate between liposomes and extracellular vesicles. Adv Healthc Mater 12(25):e2300319
Ganeshpurkar A, Saluja AK (2017) The pharmacological potential of rutin. Saudi Pharm J 25(2):149–164
Garcia-Castillo MD, Chinnapen DJ, Lencer WI (2017) Membrane transport across polarized epithelia. Cold Spring Harb Perspect Biol 9(9):a027912
Geiser M, Quaile O, Wenk A, Wigge C, Eigeldinger-Berthou S, Hirn S, Schäffler M, Schleh C, Möller W, Mall MA, Kreyling WG (2013) Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease. Particle Fibre Toxicol 10(1):19
Girisa S, Shabnam B, Monisha J, Fan L, Halim CE, Arfuso F, Ahn KS, Sethi G, Kunnumakkara AB (2019) Potential of zerumbone as an anti-cancer agent. Molecules 24(4):734
Gu W, Yuan Y, Yang H, Wu H, Wang L, Tang Z, Li Q (2018) Role of miR-195 in cigarette smoke-induced chronic obstructive pulmonary disease. Int Immunopharmacol 55:49–54
Gu W, Yuan Y, Wang L, Yang H, Li S, Tang Z, Li Q (2019) Long non-coding RNA TUG1 promotes airway remodelling by suppressing the miR-145-5p/DUSP6 axis in cigarette smoke-induced COPD. J Cell Mol Med 23(11):7200–7209
Han MK, Muellerova H, Curran-Everett D, Dransfield MT, Washko GR, Regan EA, Bowler RP, Beaty TH, Hokanson JE, Lynch DA, Jones PW, Anzueto A, Martinez FJ, Crapo JD, Silverman EK, Make BJ (2013) GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med 1(1):43–50
Han Y, Zhu Y, Youngblood HA, Almuntashiri S, Jones TW, Wang X, Liu Y, Somanath PR, Zhang D (2022) Nebulization of extracellular vesicles: a promising small RNA delivery approach for lung diseases. J Control Release 352:556–569
Han MK, Barreto TA, Martinez FJ, Comstock AT, Sajjan US (2020) Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease. BMJ Open Respir Res 7(1):e000392
Hanafy NAN, El-Kemary M, Leporatti S (2018) Micelles structure development as a strategy to improve smart cancer therapy. Cancers (Basel) 10(7):238
Haque MA, Jantan I, Harikrishnan H (2018) Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways. Int Immunopharmacol 55:312–322
Hardwick J, Taylor J, Mehta M, Satija S, Paudel KR, Hansbro PM, Chellappan DK, Bebawy M, Dua K (2021) Targeting cancer using curcumin encapsulated vesicular drug delivery systems. Curr Pharm Des 27(1):2–14
Hasan AA, Tatarskiy V, Kalinina E (2022) Synthetic pathways and the therapeutic potential of quercetin and curcumin. Int J Mol Sci 23(22):14413
Hashim YZ, Phirdaous A, Azura A (2014) Screening of anticancer activity from agarwood essential oil. Pharmacognosy Res 6(3):191–194
Hashim YZ, Kerr PG, Abbas P, Mohd Salleh H (2016) Aquilaria spp. (agarwood) as source of health beneficial compounds: a review of traditional use, phytochemistry and pharmacology. J Ethnopharmacol 189:331–360
Haynes A, Shaik MS, Chatterjee A, Singh M (2005) Formulation and evaluation of aerosolized celecoxib for the treatment of lung cancer. Pharm Res 22(3):427–439
Herbst RS, Heymach JV, Lippman SM (2008) Lung cancer. N Engl J Med 359(13):1367–1380
Ho YC, Lee SS, Yang ML, Huang-Liu R, Lee CY, Li YC, Kuan YH (2017) Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NFκB pathway. Chem Biol Interact 271:9–14
Hodge G, Roscioli E, Jersmann H, Tran HB, Holmes M, Reynolds PN, Hodge S (2016) Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes. Respir Res 17(1):135
Horita N, Miyazawa N, Kojima R, Inoue M, Ishigatsubo Y, Kaneko T (2016) Chronic use of theophylline and mortality in chronic obstructive pulmonary disease: a meta-analysis. Arch Bronconeumol 52(5):233–238
Hou X, Zaks T, Langer R, Dong Y (2021) Lipid nanoparticles for mRNA delivery. Nat Rev Mater 6(12):1078–1094
Hu Z, Zeng Q, Zhang B, Liu H, Wang W (2014) Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induced cisplatin sensitization of non-small cell lung cancer cells. Biochimie 107(Pt B):257–262
Huang X, Zhu Z, Guo X, Kong X (2019) The roles of microRNAs in the pathogenesis of chronic obstructive pulmonary disease. Int Immunopharmacol 67:335–347
Huo HX, Zhu ZX, Song YL, Shi SP, Sun J, Sun H, Zhao YF, Zheng J, Ferreira D, Zjawiony JK, Tu PF, Li J (2018) Anti-inflammatory dimeric 2-(2-phenylethyl)chromones from the resinous wood of Aquilaria sinensis. J Nat Prod 81(3):543–553
Ibrahim MY, Abdul AB, Ibrahim TAT, Mustafa MR, Elhassan MM, Mohan S (2010) Evaluation of acute toxicity and the effect of single injected doses of zerumbone on the kidney and liver functions in Sprague Dawley rats. Afr J Biotechnol 9(28):4442–4450
Imran M, Paudel KR, Jha SK, Hansbro PM, Dua K, Mohammed Y (2022) Dressing multifunctional nanoparticles with natural cell-derived membranes for superior chemotherapy. Nanomedicine (Lond) 17(10):665–670
Jaiswal M, Dudhe R, Sharma PK (2015) Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech 5(2):123–127
Jamieson KC, Traves SL, Kooi C, Wiehler S, Dumonceaux CJ, Maciejewski BA, Arnason JW, Michi AN, Leigh R, Proud D (2019) Rhinovirus and bacteria synergistically induce IL-17C release from human airway epithelial cells to promote neutrophil recruitment. J Immunol 202(1):160–170
Jantan I, Haque MA, Ilangkovan M, Arshad L (2019) Zerumbone from Zingiber zerumbet inhibits innate and adaptive immune responses in Balb/C mice. Int Immunopharmacol 73:552–559
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61(2):69–90
Jeon T, Luther DC, Goswami R, Bell C, Nagaraj H, Cicek YA, Huang R, Mas-Rosario JA, Elia JL, Im J, Lee YW, Liu Y, Scaletti F, Farkas ME, Mager J, Rotello VM (2023) Engineered polymer-siRNA polyplexes provide effective treatment of lung inflammation. ACS Nano 17(5):4315–4326
Jeong K, Yu YJ, You JY, Rhee WJ, Kim JA (2020) Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model. Lab Chip 20(3):548–557
Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC (2012) Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev 41(7):2971–3010
Kang CG, Lee HJ, Kim SH, Lee EO (2016) Zerumbone suppresses osteopontin-induced cell invasion through inhibiting the FAK/AKT/ROCK pathway in human non-small cell lung cancer A549 cells. J Nat Prod 79(1):156–160
Kanipandian N, Li D, Kannan S (2019) Induction of intrinsic apoptotic signaling pathway in A549 lung cancer cells using silver nanoparticles from Gossypium hirsutum and evaluation of in vivo toxicity. Biotechnol Rep 23:e00339
Kannaujiya VK, De Rubis G, Paudel KR, Manandhar B, Chellappan DK, Singh SK, MacLoughlin R, Gupta G, Xenaki D, Kumar P, Hansbro PM, Oliver BGG, Wich PR, Dua K (2023) Anticancer activity of NFκB decoy oligonucleotide-loaded nanoparticles against human lung cancer. J Drug Deliv Sci Technol 82:104328
Karthikeyan S, Rajendra Prasad N, Ganamani A, Balamurugan E (2013) Anticancer activity of resveratrol-loaded gelatin nanoparticles on NCI-H460 non-small cell lung cancer cells. Biomed Prev Nutr 3(1):64–73
Katiyar SK, Meeran SM, Katiyar N, Akhtar S (2009) p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog 48(1):24–37
Kc BB, Khanal P, Oli LK, Dhital SR, Pradhan B, Pahari DP, Paudel KR (2022) Prevalence and factors associated with tobacco use among high school students. J Nepal Health Res Counc 20(2):310–315
Kelly C, Yadav AB, Lawlor C, Nolan K, O’Dwyer J, Greene CM, McElvaney NG, Sivadas N, Ramsey JM, Cryan SA (2014) Therapeutic aerosol bioengineering of siRNA for the treatment of inflammatory lung disease by TNFα gene silencing in macrophages. Mol Pharm 11(11):4270–4279
Kesharwani SS, Bhat GJ (2020) Formulation and nanotechnology-based approaches for solubility and bioavailability enhancement of zerumbone. Medicina (Kaunas) 56(11):557
Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG (2015) Dendrimer-inspired nanomaterials for the in vivo delivery of siRNA to lung vasculature. Nano Lett 15(5):3008–3016
Khan I, Bahuguna A, Kumar P, Bajpai VK, Kang SC (2018) In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis. Sci Rep 8(1):144
Khan P, Siddiqui JA, Lakshmanan I, Ganti AK, Salgia R, Jain M, Batra SK, Nasser MW (2021) RNA-based therapies: a cog in the wheel of lung cancer defense. Mol Cancer 20(1):54
Khursheed R, Dua K, Vishwas S, Gulati M, Jha NK, Aldhafeeri GM, Alanazi FG, Goh BH, Gupta G, Paudel KR, Hansbro PM, Chellappan DK, Singh SK (2022) Biomedical applications of metallic nanoparticles in cancer: current status and future perspectives. Biomed Pharmacother 150:112951
Khursheed R, Paudel KR, Gulati M, Vishwas S, Jha NK, Hansbro PM, Oliver BG, Dua K, Singh SK (2022) Expanding the arsenal against pulmonary diseases using surface-functionalized polymeric micelles: breakthroughs and bottlenecks. Nanomedicine (Lond) 17(12):881–911
Kim MJ, Yun JM (2019) Molecular mechanism of the protective effect of zerumbone on lipopolysaccharide-induced inflammation of THP-1 cell-derived macrophages. J Med Food 22(1):62–73
Kim SH, Kim M-J, Kim YJ, Chang H, Kim JW, Lee J-O, Lee K-W, Kim JH, Bang S-M, Lee JS (2017) Paclitaxel as third-line chemotherapy for small cell lung cancer failing both etoposide- and camptothecin-based chemotherapy. Medicine 96(42):e8176
Kobayashi H, Brechbiel MW (2003) Dendrimer-based macromolecular MRI contrast agents: characteristics and application. Mol Imaging 2(1):1–10
Konduri KS, Nandedkar S, Düzgünes N, Suzara V, Artwohl J, Bunte R, Gangadharam PR (2003) Efficacy of liposomal budesonide in experimental asthma. J Allergy Clin Immunol 111(2):321–327
Kumar SP, Birundha K, Kaveri K, Devi KTR (2015) Antioxidant studies of chitosan nanoparticles containing naringenin and their cytotoxicity effects in lung cancer cells. Int J Biol Macromol 78:87–95
Kumbhar P, Manjappa A, Shah R, Jha NK, Singh SK, Dua K, Disouza J, Patravale V (2022) Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges. J Control Release 341:1–15
Kumbhar P, Kaur J, De Rubis G, Paudel KR, Prasher P, Patel VK, Corrie L, Chellappan DK, Gupta G, Singh SK, Patravale V, Disouza J, Dua K (2023) Inhalation drug delivery in combating pulmonary infections: advances and challenges. J Drug Deliv Sci Technol 89:105022
Labaki WW, Han MK (2020) Chronic respiratory diseases: a global view. Lancet Respir Med 8(6):531–533
Lambert AA, Dransfield MT (2016) COPD overlap syndromes: asthma and beyond. Chronic Obstr Pulm Dis 3(1):459–465
Lamprecht A, Ubrich N, Yamamoto H, Schäfer U, Takeuchi H, Maincent P, Kawashima Y, Lehr CM (2001) Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. J Pharmacol Exp Ther 299(2):775–781
Leduc C, Antoni D, Charloux A, Falcoz PE, Quoix E (2017) Comorbidities in the management of patients with lung cancer. Eur Respir J 49(3):1601721
Lee CH, Chen JC, Hsiang CY, Wu SL, Wu HC, Ho TY (2007) Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells. Pharmacol Res 56(3):193–201
Leuppi JD, Schuetz P, Bingisser R, Bodmer M, Briel M, Drescher T, Duerring U, Henzen C, Leibbrandt Y, Maier S, Miedinger D, Müller B, Scherr A, Schindler C, Stoeckli R, Viatte S, von Garnier C, Tamm M, Rutishauser J (2013) Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. Jama 309(21):2223–2231
Li CL, Tan LH, Wang YF, Luo CD, Chen HB, Lu Q, Li YC, Yang XB, Chen JN, Liu YH, Xie JH, Su ZR (2019) Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo. Phytomedicine 52:272–283
Li Z, Chen G, Ding L, Wang Y, Zhu C, Wang K, Li J, Sun M, Oupicky D (2019) Increased survival by pulmonary treatment of established lung metastases with dual STAT3/CXCR4 inhibition by siRNA nanoemulsions. Mol Ther 27(12):2100–2110
Li Z, Yang L, Wang H, Binzel DW, Williams TM, Guo P (2021) Non-small-cell lung cancer regression by siRNA delivered through exosomes that display EGFR RNA aptamer. Nucleic Acid Ther 31(5):364–374
Li C, Qiu Y, Zhang Y (2022) Research progress on therapeutic targeting of cancer-associated fibroblasts to tackle treatment-resistant NSCLC. Pharmaceuticals (Basel) 15(11):1411
Lin K, Liu S, Shen Y, Li Q (2013) Berberine attenuates cigarette smoke-induced acute lung inflammation. Inflammation 36(5):1079–1086
Lin C, Wong BCK, Chen H, Bian Z, Zhang G, Zhang X, Kashif Riaz M, Tyagi D, Lin G, Zhang Y, Wang J, Lu A, Yang Z (2017) Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy. Sci Rep 7(1):1097
Liu CS, Zheng YR, Zhang YF, Long XY (2016) Research progress on berberine with a special focus on its oral bioavailability. Fitoterapia 109:274–282
Liu TT, Mu LQ, Dai W, Wang CB, Liu XY, Xiang DX (2016) Preparation, characterization, and evaluation of antitumor effect of Brucea javanica oil cationic nanoemulsions. Int J Nanomedicine 11:2515–2529
Liu D, Meng X, Wu D, Qiu Z, Luo H (2019) A natural isoquinoline alkaloid with antitumor activity: studies of the biological activities of berberine. Front Pharmacol 10:9
Liu XN, Zhang CB, Lin H, Tang XY, Zhou R, Wen HL, Li J (2021) microRNA-204 shuttled by mesenchymal stem cell-derived exosomes inhibits the migration and invasion of non-small-cell lung cancer cells via the KLF7/AKT/HIF-1α axis. Neoplasma 68(4):719–731
Liu H, Li Y, Zhang X, Shi M, Li D, Wang Y (2022b) Chitosan-coated solid lipid nano-encapsulation improves the therapeutic antiairway inflammation effect of berberine against COPD in cigarette smoke-exposed rats. Can Respir J 2022:8509396
Liu R, Liu R, Guo Z, Ren J, Huang J, Luo Q, Tan Q (2022c) shRNA-mediated knockdown of KNTC1 inhibits non-small-cell lung cancer through regulating PSMB8. Cell Death Dis 13(8):685
Liu S, Wang W, Ning Y, Zheng H, Zhan Y, Wang H, Yang Y, Luo J, Wen Q, Zang H, Peng J, Ma J, Fan S (2022d) Exosome-mediated miR-7-5p delivery enhances the anticancer effect of Everolimus via blocking MNK/eIF4E axis in non-small cell lung cancer. Cell Death Dis 13(2):129
Liu G, Jarnicki AG, Paudel KR, Lu W, Wadhwa R, Philp AM, Van Eeckhoutte H, Marshall JE, Malyla V, Katsifis A, Fricker M, Hansbro NG, Dua K, Kermani NZ, Eapen MS, Tiotiu A, Chung KF, Caramori G, Bracke K, Adcock IM, Sohal SS, Wark PA, Oliver BG, Hansbro PM (2022a) Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease. Eur Respir J 60(6):2101431
Löndahl J, Möller W, Pagels JH, Kreyling WG, Swietlicki E, Schmid O (2014) Measurement techniques for respiratory tract deposition of airborne nanoparticles: a critical review. J Aerosol Med Pulm Drug Deliv 27(4):229–254
Longmire M, Choyke PL, Kobayashi H (2008) Dendrimer-based contrast agents for molecular imaging. Curr Top Med Chem 8(14):1180–1186
Lu F, Zhang HT (2011) DNA methylation and nonsmall cell lung cancer. Anat Rec (Hoboken) 294(11):1787–1795
Luan X, Sansanaphongpricha K, Myers I, Chen H, Yuan H, Sun D (2017) Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin 38(6):754–763
Lugg ST, Scott A, Parekh D, Naidu B, Thickett DR (2022) Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease. Thorax 77(1):94–101
MacNee W (2005) Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2(1):50–60
Magalhaes M, Jorge J, Goncalves AC, Sarmento-Ribeiro AB, Carvalho R, Figueiras A, Santos AC, Veiga F (2020) miR-29b and retinoic acid co-delivery: a promising tool to induce a synergistic antitumoral effect in non-small cell lung cancer cells. Drug Deliv Transl Res 10(5):1367–1380
Malyla V, De Rubis G, Paudel KR, Chellappan DK, Hansbro NG, Hansbro PM, Dua K (2023) Berberine nanostructures attenuate ß-catenin, a key component of epithelial mesenchymal transition in lung adenocarcinoma. Naunyn Schmiedebergs Arch Pharmacol. https://doi.org/10.1007/s00210-023-02553-y
Manandhar B, Paudel KR, Panth N, Hansbro P, Oliver BG, Dua K (2022) Applications of extracellular vesicles as a drug-delivery system for chronic respiratory diseases. Nanomedicine (Lond) 17(12):817–820
Manandhar B, Paudel KR, Clarence DD, De Rubis G, Madheswaran T, Panneerselvam J, Zacconi FC, Williams KA, Pont LG, Warkiani ME, MacLoughlin R, Oliver BG, Gupta G, Singh SK, Chellappan DK, Hansbro PM, Dua K (2023) Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro. Naunyn Schmiedebergs Arch Pharmacol. https://doi.org/10.1007/s00210-023-02603-5
Manzanares D, Ceña V (2020) Endocytosis: the nanoparticle and submicron nanocompounds gateway into the cell. Pharmaceutics 12(4):371
Martinez FJ, Calverley PM, Goehring UM, Brose M, Fabbri LM, Rabe KF (2015) Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet 385(9971):857–866
Massion PP, Carbone DP (2003) The molecular basis of lung cancer: molecular abnormalities and therapeutic implications. Respir Res 4(1):12
Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442
McCaskill J, Singhania R, Burgess M, Allavena R, Wu S, Blumenthal A, McMillan NA (2013) Efficient biodistribution and gene silencing in the lung epithelium via intravenous liposomal delivery of siRNA. Mol Ther Nucleic Acids 2(6):e96
Md S, Alhakamy NA, Aldawsari HM, Husain M, Kotta S, Abdullah ST, Fahmy UA, Alfaleh MA, Asfour HZ (2020) Formulation design, statistical optimization, and in vitro evaluation of a naringenin nanoemulsion to enhance apoptotic activity in A549 lung cancer cells. Pharmaceuticals (Basel) 13(7):152
Mehta M, Dhanjal DS, Paudel KR, Singh B, Gupta G, Rajeshkumar S, Thangavelu L, Tambuwala MM, Bakshi HA, Chellappan DK, Pandey P, Dureja H, Charbe NB, Singh SK, Shukla SD, Nammi S, Aljabali AA, Wich PR, Hansbro PM, Satija S, Dua K (2020) Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update. Inflammopharmacology 28(4):795–817
Mehta M, Paudel KR, Shukla SD, Shastri MD, Singh SK, Gulati M, Dureja H, Gupta G, Satija S, Hansbro PM, Chellappan DK, Dua K (2020) Interferon therapy for preventing COPD exacerbations. Excli j 19:1477–1480
Mehta M, Malyla V, Paudel KR, Chellappan DK, Hansbro PM, Oliver BG, Dua K (2021) Berberine loaded liquid crystalline nanostructure inhibits cancer progression in adenocarcinomic human alveolar basal epithelial cells in vitro. J Food Biochem 45(11):e13954
Mehta M, Paudel KR, Shukla SD, Allam V, Kannaujiya VK, Panth N, Das A, Parihar VK, Chakraborty A, Ali MK, Jha NK, Xenaki D, Su QP, Wich PR, Adams J, Hansbro PM, Chellappan DK, Oliver BGG, Dua K (2021) Recent trends of NFκB decoy oligodeoxynucleotide-based nanotherapeutics in lung diseases. J Control Release 337:629–644
Mehta M, Paudel KR, Shukla SD, Shastri MD, Satija S, Singh SK, Gulati M, Dureja H, Zacconi FC, Hansbro PM, Chellappan DK, Dua K (2021) Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation. Future Med Chem 13(6):543–549
Mei D, Tan WSD, Tay Y, Mukhopadhyay A, Wong WSF (2020) Therapeutic RNA strategies for chronic obstructive pulmonary disease. Trends Pharmacol Sci 41(7):475–486
Mikušová V, Mikuš P (2021) Advances in chitosan-based nanoparticles for drug delivery. Int J Mol Sci 22(17):9652
Miravitlles M, Ribera A (2017) Understanding the impact of symptoms on the burden of COPD. Respir Res 18(1):67
Mishra B, Singh J (2020) Novel drug delivery systems and significance in respiratory diseases. Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems 2020:57–95. https://doi.org/10.1016/B978-0-12-820658-4.00004-2
Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R (2021) Engineering precision nanoparticles for drug delivery. Nat Rev Drug Disc 20(2):101–124
Mo J, Milleret G, Nagaraj M (2017) Liquid crystal nanoparticles for commercial drug delivery. Liq Cryst Rev 5(2):69–85
Mohamad MSB, Reyes RJ, De Rubis G, Paudel KR, Hansbro PM, Dua K, Chellappan DK (2023) The versatility of 18ß-glycyrrhetinic acid in attenuating pulmonary inflammatory disorders. Excli J 22:188–190
Morty RE, Königshoff M, Eickelberg O (2009) Transforming growth factor-beta signaling across ages: from distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc 6(7):607–613
Moulaie S, Mirzaie A, Aliasgari E (2018) Antibacterial and anticancer activities of silver nanoparticles fabricated by the Artemisia scoparia extract against lung cancer cell line (A549). KAUMS J (FEYZ) 22(5):487–496
Muddineti OS, Shah A, Rompicharla SVK, Ghosh B, Biswas S (2018) Cholesterol-grafted chitosan micelles as a nanocarrier system for drug-siRNA co-delivery to the lung cancer cells. Int J Biol Macromol 118:857–863
Munagala R, Aqil F, Jeyabalan J, Gupta RC (2016) Bovine milk-derived exosomes for drug delivery. Cancer Lett 371(1):48–61
Murugan D, Rangasamy L (2023) A perspective to weaponize microRNAs against lung cancer. Noncoding RNA Res 8(1):18–32
Nakamura Y, Mochida A, Choyke PL, Kobayashi H (2016) Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer? Bioconjug Chem 27(10):2225–2238
Nakhaei P, Margiana R, Bokov DO, Abdelbasset WK, Jadidi Kouhbanani MA, Varma RS, Marofi F, Jarahian M, Beheshtkhoo N (2021) Liposomes: structure, biomedical applications, and stability parameters with emphasis on cholesterol. Front Bioeng Biotechnol 9:705886
Nakhlband A, Barar J, Bidmeshkipour A, Heidari HR, Omidi Y (2010) Bioimpacts of anti epidermal growth factor receptor antisense complexed with polyamidoamine dendrimers in human lung epithelial adenocarcinoma cells. J Biomed Nanotechnol 6(4):360–369
Navaei Shoorvarzi S, Shahraki F, Shafaei N, Karimi E, Oskoueian E (2020) Citrus aurantium L. bloom essential oil nanoemulsion: synthesis, characterization, cytotoxicity, and its potential health impacts on mice. J Food Biochem 44(5):e13181
Nichols JW, Bae YH (2014) EPR: evidence and fallacy. J Control Release 190:451–464
Nie S (2010) Understanding and overcoming major barriers in cancer nanomedicine. Nanomedicine (Lond) 5(4):523–528
Nie H, Xie X, Zhang D, Zhou Y, Li B, Li F, Li F, Cheng Y, Mei H, Meng H, Jia L (2020) Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer. Nanoscale 12(2):877–887
Nishimura A, Akeda K, Matsubara T, Kusuzaki K, Matsumine A, Masuda K, Gemba T, Uchida A, Sudo A (2011) Transfection of NF-κB decoy oligodeoxynucleotide suppresses pulmonary metastasis by murine osteosarcoma. Cancer Gene Ther 18(4):250–259
Njatcha C, Farooqui M, Kornberg A, Johnson DE, Grandis JR, Siegfried JM (2018) STAT3 cyclic decoy demonstrates robust antitumor effects in non-small cell lung cancer. Mol Cancer Ther 17(9):1917–1926
Nsonwu-Anyanwu AC, Egom OU, Eworo RE, Nsonwu MC, Aniekpon UF, Ekpo DO, Opara Usoro CA (2022) Risk of pulmonary-reproductive dysfunctions, inflammation and oxidative DNA damage in exposure to polycyclic aromatic hydrocarbon in cigarette smokers. Med J Islam Repub Iran 36:108
Nucera F, Mumby S, Paudel KR, Dharwal V, Di Stefano A, Casolaro V, Hansbro PM, Adcock IM, Caramori G (2022) Role of oxidative stress in the pathogenesis of COPD. Minerva Med 113(3):370–404
Nucera F, Hansbro PM, Paudel KR, Casolaro V, Appanna R, Kirkham P, Adcock IM, Caramori G (2022) Chapter 14—role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema. Translational Autoimmunity. N. Rezaei, Academic Press. 3: 311-331
Och A, Podgórski R, Nowak R (2020) Biological activity of berberine—a summary update. Toxins (Basel) 12(11):713
Oh YJ, Lee J, Seo JY, Rhim T, Kim S-H, Yoon HJ, Lee KY (2011) Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model. J Control Release 150(1):56–62
Okuda T, Kito D, Oiwa A, Fukushima M, Hira D, Okamoto H (2013) Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique. Biol Pharm Bull 36(7):1183–1191
Oliviu V, Simona Codruta H, Lorena F (2020) Safety profile of essential oils. Essential Oils. Essential Oils - Bioactive Compounds, New Perspectives and Applications. IntechOpen. https://doi.org/10.5772/intechopen.91363
Otterson GA, Villalona-Calero MA, Sharma S, Kris MG, Imondi A, Gerber M, White DA, Ratain MJ, Schiller JH, Sandler A, Kraut M, Mani S, Murren JR (2007) Phase I study of inhaled doxorubicin for patients with metastatic tumors to the lungs. Clin Cancer Res 13(4):1246–1252
Padinharayil H, Alappat RR, Joy LM, Anilkumar KV, Wilson CM, George A, Valsala Gopalakrishnan A, Madhyastha H, Ramesh T, Sathiyamoorthi E, Lee J, Ganesan R (2022) Advances in the lung cancer immunotherapy approaches. Vaccines (Basel) 10(11):1963
Padmini R, Nallal VUM, Razia M, Sivaramakrishnan S, Alodaini HA, Hatamleh AA, Al-Dosary MA, Ranganathan V, Chung WJ (2022) Cytotoxic effect of silver nanoparticles synthesized from ethanolic extract of Allium sativum on A549 lung cancer cell line. J King Saud Univ - Sci 34(4):102001
Pain M, Bermudez O, Lacoste P, Royer PJ, Botturi K, Tissot A, Brouard S, Eickelberg O, Magnan A (2014) Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype. Eur Respir Rev 23(131):118–130
Palmerston Mendes L, Pan J, Torchilin VP (2017) Dendrimers as nanocarriers for nucleic acid and drug delivery in cancer therapy. Molecules 22(9):1401
Pan GY, Wang GJ, Liu XD, Fawcett JP, Xie YY (2002) The involvement of P-glycoprotein in berberine absorption. Pharmacol Toxicol 91(4):193–197
Paranjpe M, Müller-Goymann CC (2014) Nanoparticle-mediated pulmonary drug delivery: a review. Int J Mol Sci 15(4):5852–5873
Parashar P, Rathor M, Dwivedi M, Saraf SA (2018) Hyaluronic acid decorated naringenin nanoparticles: appraisal of chemopreventive and curative potential for lung cancer. Pharmaceutics 10(1):33
Parayath NN, Parikh A, Amiji MM (2018) Repolarization of tumor-associated macrophages in a genetically engineered nonsmall cell lung cancer model by intraperitoneal administration of hyaluronic acid-based nanoparticles encapsulating MicroRNA-125b. Nano Letters 18(6):3571–3579
Park H, Cho J, Lee J, Park YS, Lee CH, Lee SM, Yoo CG, Kim YW, Han SK, Choi SM (2022) Prevalence and impact of airway diseases on clinical outcomes in idiopathic pulmonary fibrosis. Korean J Intern Med 37(2):387–397
Patel VK, Paudel KR, Shukla SD, Liu G, Oliver BG, Hansbro PM, Dua K (2022) Toll-like receptors, innate immune system, and lung diseases: a vital trilateral association. Excli J 21:519–523
Pathak N, Chitikela S, Malik PS (2021) Recent advances in lung cancer genomics: application in targeted therapy. Adv Genet 108:201–275
Patil S, Choudhary B, Rathore A, Roy K, Mahadik K (2015) Enhanced oral bioavailability and anticancer activity of novel curcumin loaded mixed micelles in human lung cancer cells. Phytomedicine 22(12):1103–1111
Paudel KR, Dharwal V, Patel VK, Galvao I, Wadhwa R, Malyla V, Shen SS, Budden KF, Hansbro NG, Vaughan A, Yang IA, Kohonen-Corish MRJ, Bebawy M, Dua K, Hansbro PM (2020) Role of lung microbiome in innate immune response associated with chronic lung diseases. Front Med (Lausanne) 7:554
Paudel KR, Wadhwa R, Mehta M, Chellappan DK, Hansbro PM, Dua K (2020) Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro. Toxicol In Vitro 68:104961
Paudel KR, Wadhwa R, Tew XN, Lau NJX, Madheswaran T, Panneerselvam J, Zeeshan F, Kumar P, Gupta G, Anand K, Singh SK, Jha NK, MacLoughlin R, Hansbro NG, Liu G, Shukla SD, Mehta M, Hansbro PM, Chellappan DK, Dua K (2021) Rutin loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro. Life Sci 276:119436
Paudel KR, De Rubis G, Panth N, Singh SK, Chellappan DK, Hansbro PM, Dua K (2022a) Nanomedicine and medicinal plants: emerging symbiosis in managing lung diseases and associated infections. Excli J 21:1299–1303
Paudel KR, Dua K, Panth N, Hansbro PM, Chellappan DK (2022b) Advances in research with rutin-loaded nanoformulations in mitigating lung diseases. Future Med Chem 14(18):1293–1295
Paudel KR, Mehta M, Shukla SD, Panth N, Chellappan DK, Dua K, Hansbro P (2022c) Advancements in nanotherapeutics targeting senescence in chronic obstructive pulmonary disease. Nanomedicine (Lond) 17(23):1757–1760
Paudel KR, Mehta M, Yin GHS, Yen LL, Malyla V, Patel VK, Panneerselvam J, Madheswaran T, MacLoughlin R, Jha NK, Gupta PK, Singh SK, Gupta G, Kumar P, Oliver BG, Hansbro PM, Chellappan DK, Dua K (2022d) Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro. Environ Sci Pollut Res Int 29(31):46830–46847
Paudel KR, Panth N, Manandhar B, Singh SK, Gupta G, Wich PR, Nammi S, MacLoughlin R, Adams J, Warkiani ME, Chellappan DK, Oliver BG, Hansbro PM, Dua K (2022e) Attenuation of cigarette-smoke-induced oxidative stress, senescence, and inflammation by berberine-loaded liquid crystalline nanoparticles: in vitro study in 16HBE and RAW264.7 cells. Antioxidants (Basel) 11(5):873
Paudel KR, Manandhar B, Singh SK, Gupta G, Hansbro PM, Chellappan DK, Dua K (2023) Cytotoxic mechanisms of berberine-phytantriol liquid crystalline nanoparticles against non-small-cell lung cancer. Excli J 22:516–519
Paudel KR, Rajput R, De Rubis G, Raju Allam VSR, Williams KA, Singh SK, Gupta G, Salunke P, Hansbro PM, Gerlach J, Dua K (2023) In vitro anti-cancer activity of a polyherbal preparation, VEDICINALS®9, against A549 human lung adenocarcinoma cells. Pathol Res Pract 250:154832
Peng PL, Hsieh YS, Wang CJ, Hsu JL, Chou FP (2006) Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicol Appl Pharmacol 214(1):8–15
Peng J, Cai Z, Wang Q, Zhou J, Xu J, Pan D, Chen T, Zhang G, Tao L, Chen Y, Shen X (2022) Carboxymethyl chitosan modified oxymatrine liposomes for the alleviation of emphysema in mice via pulmonary administration. Molecules 27(11):3610
Pereira FG, Marquete R, Oliveira-Cruz L, Quintanilha-Falcão D, Mansur E, de Lima Moreira D (2017) Cytotoxic effects of the essential oil from leaves of Casearia sylvestris Sw. (Salicaceae) and its nanoemulsion on A549 tumor cell line. Bol Latinoam y del Caribe de Plantas Medicinales y Aromáticas 16(5):506–512
Poole P, Black PN, Cates CJ (2012) Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev 15(8):CD001287
Prasher P, Sharma M, Mehta M, Satija S, Aljabali AA, Tambuwala MM, Anand K, Sharma N, Dureja H, Jha NK, Gupta G, Gulati M, Singh SK, Chellappan DK, Paudel KR, Hansbro PM, Dua K (2021) Current-status and applications of polysaccharides in drug delivery systems. Colloid Interf Sci Commun 42:100418
Prasher P, Sharma M, Kumar Singh S, Gulati M, Kumar D, Gupta G, Kumar Chellappan D, Gregory George Oliver B, Wich PR, Dua K (2022) Versatility of acetalated dextran in nanocarriers targeting respiratory diseases. Mater Lett 323:132600
Prasher P, Sharma M, Singh SK, Gulati M, Chellappan DK, Zacconi F, De Rubis G, Gupta G, Sharifi-Rad J, Cho WC, Dua K (2022) Luteolin: a flavonoid with a multifaceted anticancer potential. Cancer Cell Int 22(1):386
Prasher P, Sharma M, Singh SK, Gulati M, Jha NK, Gupta PK, Gupta G, Chellappan DK, Zacconi F, de Jesus Andreoli T, Pinto Y, Chan G, Liu KR, Paudel PM, Hansbro BG, Oliver George, Dua K (2022) Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems. Chem Biol Interact 365:110048
Prasher P, Sharma M, Singh SK, Haghi M, MacLoughlin R, Chellappan DK, Gupta G, Paudel KR, Hansbro PM, George Oliver BG, Wich PR, Dua K (2022) Advances and applications of dextran-based nanomaterials targeting inflammatory respiratory diseases. J Drug Deliv Sci Technol 74:103598
Qiao J-B, Jang Y, Fan Q-Q, Chang S-H, Xing L, Cui P-F, He Y-J, Lee S, Hwang S, Cho M-H, Jiang H-L (2017) Aerosol delivery of biocompatible dihydroergotamine-loaded PLGA-PSPE polymeric micelles for efficient lung cancer therapy. Polym Chem 8(9):1540–1554
Quéméner AM, Bachelot L, Aubry M, Avner S, Leclerc D, Salbert G, Cabillic F, Decaudin D, Mari B, Mouriaux F, Galibert MD, Gilot D (2022) Non-canonical miRNA-RNA base-pairing impedes tumor suppressor activity of miR-16. Life Sci Alliance 5(12):e202201643
Rajeshkumar S, Kumar SV, Ramaiah A, Agarwal H, Lakshmi T, Roopan SM (2018) Biosynthesis of zinc oxide nanoparticles usingMangifera indica leaves and evaluation of their antioxidant and cytotoxic properties in lung cancer (A549) cells. Enzym Microb Technol 117:91–95
Ramanunny AK, Wadhwa S, Gulati M, Singh SK, Kapoor B, Dureja H, Chellappan DK, Anand K, Dua K, Khursheed R, Awasthi A, Kumar R, Kaur J, Corrie L, Pandey NK (2021) Nanocarriers for treatment of dermatological diseases: principle, perspective and practices. Eur J Pharmacol 890:173691
Raso MG, Bota-Rabassedas N, Wistuba II (2021) Pathology and classification of SCLC. Cancers (Basel) 13(4):820
Reid G, Kao SC, Pavlakis N, Brahmbhatt H, MacDiarmid J, Clarke S, Boyer M, van Zandwijk N (2016) Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer. Epigenomics 8(8):1079–1085
Reimann S, Fink L, Wilhelm J, Hoffmann J, Bednorz M, Seimetz M, Dessureault I, Troesser R, Ghanim B, Klepetko W, Seeger W, Weissmann N, Kwapiszewska G (2015) Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema. Respir Res 16:127
Riaz MK, Zhang X, Wong KH, Chen H, Liu Q, Chen X, Zhang G, Lu A, Yang Z (2019) Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy. Int J Nanomedicine 14:2879–2902
Riley CM, Sciurba FC (2019) Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review. Jama 321(8):786–797
Rizvi SAA, Saleh AM (2018) Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J 26(1):64–70
Roa WH, Azarmi S, Al-Hallak MH, Finlay WH, Magliocco AM, Löbenberg R (2011) Inhalable nanoparticles, a non-invasive approach to treat lung cancer in a mouse model. J Control Release 150(1):49–55
Roy M, Roy A, Rustagi S, Pandey N (2023) An overview of nanomaterial applications in pharmacology. Biomed Res Int 2023:4838043
Saab MM, McCarthy M, O’Driscoll M, Sahm LJ, Leahy-Warren P, Noonan B, FitzGerald S, O’Malley M, Lyons N, Burns HE, Kennedy U, Lyng Á, Hegarty J (2022) A systematic review of interventions to recognise, refer and diagnose patients with lung cancer symptoms. NPJ Prim Care Respir Med 32(1):42
Sadowska AM, Verbraecken J, Darquennes K, De Backer WA (2006) Role of N-acetylcysteine in the management of COPD. Int J Chron Obstruct Pulmon Dis 1(4):425–434
Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi SA, Sullman MJM, Ahmadian Heris J, Ansarin K, Mansournia MA, Collins GS, Kolahi AA, Kaufman JS (2022) Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990–2019: results from the Global Burden of Disease Study 2019. Bmj 378:e069679
Sciurba FC, Ernst A, Herth FJ, Strange C, Criner GJ, Marquette CH, Kovitz KL, Chiacchierini RP, Goldin J, McLennan G (2010) A randomized study of endobronchial valves for advanced emphysema. N Engl J Med 363(13):1233–1244
Seguin J, Brullé L, Boyer R, Lu YM, Ramos Romano M, Touil YS, Scherman D, Bessodes M, Mignet N, Chabot GG (2013) Liposomal encapsulation of the natural flavonoid fisetin improves bioavailability and antitumor efficacy. Int J Pharm 444(1–2):146–154
Sercombe L, Veerati T, Moheimani F, Wu SY, Sood AK, Hua S (2015) Advances and challenges of liposome assisted drug delivery. Front Pharmacol 6:286
Sham NO, Zhao L, Zhu Z, Roy TM, Xiao H, Bai Q, Wakefield MR, Fang Y (2022) Immunotherapy for non-small cell lung cancer: current agents and potential molecular targets. Anticancer Res 42(7):3275–3284
Shao N, Song L, Sun X (2021) Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis. Mol Cell Biochem 476(6):2253–2267
Sharma K, Zhang Y, Paudel KR, Kachelmeier A, Hansbro PM, Shi X (2022) The emerging role of pericyte-derived extracellular vesicles in vascular and neurological health. Cells 11(19):3108
Shastri MD, Allam V, Shukla SD, Jha NK, Paudel KR, Peterson GM, Patel RP, Hansbro PM, Chellappan DK, Dua K (2021) Interleukin-13: a pivotal target against influenza-induced exacerbation of chronic lung diseases. Life Sci 283:119871
Shi SJ, Zhong ZR, Liu J, Zhang ZR, Sun X, Gong T (2012) Solid lipid nanoparticles loaded with anti-microRNA oligonucleotides (AMOs) for suppression of microRNA-21 functions in human lung cancer cells. Pharm Res 29(1):97–109
Shipunova VO, Kovalenko VL, Kotelnikova PA, Sogomonyan AS, Shilova ON, Komedchikova EN, Zvyagin AV, Nikitin MP, Deyev SM (2021) Targeting cancer cell tight junctions enhances PLGA-based photothermal sensitizers' performance in vitro and in vivo. Pharmaceutics 14(1):43
Singh J, Jain K, Mehra NK, Jain NK (2016) Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers. Artif Cells Nanomedicine Biotechnol 44(7):1626–1634
Smola M, Vandamme T, Sokolowski A (2008) Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases. Int J Nanomedicine 3(1):1–19
Solanki N, Mehta M, Chellappan DK, Gupta G, Hansbro NG, Tambuwala MM, Aa Aljabali A, Paudel KR, Liu G, Satija S, Hansbro PM, Dua K, Dureja H (2020) Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549. Future Med Chem 12(22):2019–2034
Solanki N, Gupta G, Chellappan DK, Singh SK, Gulati M, Paudel KR, Hansbro PM, Dua K, Bhan S, Saini M, Dureja H (2023) Boswellic acids: a critical appraisal of their therapeutic and nutritional benefits in chronic inflammatory diseases. Endocr Metab Immune Disord Drug Targets. https://doi.org/10.2174/1871530323666230512154634
Song Y, Zhou B, Du X, Wang Y, Zhang J, Ai Y, Xia Z, Zhao G (2020) Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC). Biomed Pharmacother 125:109561
Su X, Wu W, Zhu Z, Lin X, Zeng Y (2022) The effects of epithelial-mesenchymal transitions in COPD induced by cigarette smoke: an update. Respir Res 23(1):225
Sukhanova A, Bozrova S, Sokolov P, Berestovoy M, Karaulov A, Nabiev I (2018) Dependence of nanoparticle toxicity on their physical and chemical properties. Nanoscale Res Lett 13(1):44
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249
Tai YL, Chen KC, Hsieh JT, Shen TL (2018) Exosomes in cancer development and clinical applications. Cancer Sci 109(8):2364–2374
Tam A, Hughes M, McNagny KM, Obeidat M, Hackett TL, Leung JM, Shaipanich T, Dorscheid DR, Singhera GK, Yang CWT, Paré PD, Hogg JC, Nickle D, Sin DD (2019) Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease. Sci Rep 9(1):3353
Tammina SK, Mandal BK, Ranjan S, Dasgupta N (2017) Cytotoxicity study of Piper nigrum seed mediated synthesized SnO(2) nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines. J Photochem Photobiol B 166:158–168
Tan CL, Chan Y, Candasamy M, Chellian J, Madheswaran T, Sakthivel LP, Patel VK, Chakraborty A, MacLoughlin R, Kumar D, Verma N, Malyla V, Gupta PK, Jha NK, Thangavelu L, Devkota HP, Bhatt S, Prasher P, Gupta G, Gulati M, Singh SK, Paudel KR, Hansbro PM, Oliver BG, Dua K, Chellappan DK (2022) Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models. Eur J Pharmacol 919:174821
Tashkin DP, Ashutosh K, Bleecker ER, Britt EJ, Cugell DW, Cummiskey JM, DeLorenzo L, Gilman MJ, Gross GN, Gross NJ et al (1986) Comparison of the anticholinergic bronchodilator ipratropium bromide with metaproterenol in chronic obstructive pulmonary disease. A 90-day multi-center study. Am J Med 81(5a):81–90
Tavakkol Afshari HS, Homayouni Tabrizi M, Ardalan T, Jalili Anoushirvani N, Mahdizadeh R (2022) Anethum graveolens essential oil nanoemulsions (AGEO-NE) as an exclusive apoptotic inducer in human lung adenocarcinoma (A549) cells. Nutr Cancer 74(4):1411–1419
Tenchov R, Bird R, Curtze AE, Zhou Q (2021) Lipid nanoparticles horizontal line from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement. ACS Nano 15(11):16982–17015
Tew XN, Xin Lau NJ, Chellappan DK, Madheswaran T, Zeeshan F, Tambuwala MM, Aljabali AA, Balusamy SR, Perumalsamy H, Gupta G, Oliver BG, Hsu A, Wark P, Reddy K, Wadhwa R, Hansbro PM, Dua K (2020) Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases. Chem Biol Interact 317:108947
Théry C, Zitvogel L, Amigorena S (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2(8):569–579
Thomas M, Lu JJ, Zhang C, Chen J, Klibanov AM (2007) Identification of novel superior polycationic vectors for gene delivery by high-throughput synthesis and screening of a combinatorial library. Pharm Res 24(8):1564–1571
Thun MJ, DeLancey JO, Center MM, Jemal A, Ward EM (2010) The global burden of cancer: priorities for prevention. Carcinogenesis 31(1):100–110
Tian W, Yang X, Yang H, Lv M, Sun X, Zhou B (2021) Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway. Cell Death Dis 12(11):1030
Tiong TY, Weng PW, Wang CH, Setiawan SA, Yadav VK, Pikatan NW, Fong IH, Yeh CT, Hsu CH, Kuo KT (2022) Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN oncometabolic axis inhibits the cancer stem-like and chemoresistant phenotype of non-small cell lung carcinoma cells. Int J Mol Sci 23(13):7283
Tong J, Lu J, Yin Y, Wang Y, Zhang K (2020) microRNA-195 promotes small cell lung cancer cell apoptosis via inhibiting Rap2C protein-dependent MAPK signal transduction. Technol Cancer Res Treat 19:1533033820977546
Torchilin VP (2006) Multifunctional nanocarriers. Adv Drug Deliv Rev 58(14):1532–1555
Tripathi AK, Ray AK, Mishra SK (2022) Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials. Beni Suef Univ J Basic Appl Sci 11(1):16
Tsai PL, Tsai TH (2004) Hepatobiliary excretion of berberine. Drug Metab Dispos 32(4):405–412
Upadhyay P, Sarker S, Ghosh A, Gupta P, Das S, Ahir M, Bhattacharya S, Chattopadhyay S, Ghosh S, Adhikary A (2019) Transferrin-decorated thymoquinone-loaded PEG-PLGA nanoparticles exhibit anticarcinogenic effect in non-small cell lung carcinoma via the modulation of miR-34a and miR-16. Biomater Sci 7(10):4325–4344
Verschraegen CF, Gilbert BE, Loyer E, Huaringa A, Walsh G, Newman RA, Knight V (2004) Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignancies. Clin Cancer Res 10(7):2319–2326
Viegas C, Patrício AB, Prata JM, Nadhman A, Chintamaneni PK, Fonte P (2023) Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review. Pharmaceutics 15(6):1593
Vij N, Min T, Bodas M, Gorde A, Roy I (2016) Neutrophil targeted nano-drug delivery system for chronic obstructive lung diseases. Nanomedicine: Nanotechnol Biol Med 12(8):2415–2427
Vijayakumar S, Vaseeharan B, Malaikozhundan B, Gopi N, Ekambaram P, Pachaiappan R, Velusamy P, Murugan K, Benelli G, Suresh Kumar R, Suriyanarayanamoorthy M (2017) Therapeutic effects of gold nanoparticles synthesized using Musa paradisiaca peel extract against multiple antibiotic resistant Enterococcus faecalis biofilms and human lung cancer cells (A549). Microb Pathog 102:173–183
Vinod SK, Hau E (2020) Radiotherapy treatment for lung cancer: current status and future directions. Respirology 25(Suppl 2):61–71
Vishweshwaraiah YL, Dokholyan NV (2022) mRNA vaccines for cancer immunotherapy. Front Immunol 13:1029069
Wadhwa R, Paudel KR, Chin LH, Hon CM, Madheswaran T, Gupta G, Panneerselvam J, Lakshmi T, Singh SK, Gulati M, Dureja H, Hsu A, Mehta M, Anand K, Devkota HP, Chellian J, Chellappan DK, Hansbro PM, Dua K (2021) Anti-inflammatory and anticancer activities of Naringenin-loaded liquid crystalline nanoparticles in vitro. J Food Biochem 45(1):e13572
Wadhwa R, Paudel KR, Shukla S, Shastri M, Gupta G, Devkota HP, Bebawy M, Chellappan DK, Hansbro PM, Dua K (2022) Epigenetic therapy as a potential approach for targeting oxidative stress–induced non-small-cell lung cancer. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Chakraborti S, Ray BK, Roychoudhury S. Singapore, Springer Nature Singapore: 1545-1560
Wan K, Sun L, Hu X, Yan Z, Zhang Y, Zhang X, Zhang J (2016) Novel nanoemulsion based lipid nanosystems for favorable in vitro and in vivo characteristics of curcumin. Int J Pharm 504(1–2):80–88
Wang XX, Li YB, Yao HJ, Ju RJ, Zhang Y, Li RJ, Yu Y, Zhang L, Lu WL (2011) The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials 32(24):5673–5687
Wang P, Zhang L, Peng H, Li Y, Xiong J, Xu Z (2013) The formulation and delivery of curcumin with solid lipid nanoparticles for the treatment of on non-small cell lung cancer both in vitro and in vivo. Mater Sci Eng C Mater Biol Appl 33(8):4802–4808
Wang CG, Li C, Lei W, Jiang JH, Huang JA, Zeng DX (2018a) The association of neuron-derived orphan receptor 1 with pulmonary vascular remodeling in COPD patients. Int J Chron Obstruct Pulmon Dis 13:1177–1186
Wang W, Zha G, Zou JJ, Wang X, Li CN, Wu XJ (2019) Berberine attenuates cigarette smoke extract-induced airway inflammation in mice: involvement of TGF-β1/Smads signaling pathway. Curr Med Sci 39(5):748–753
Wang G, Wang Y, Yao L, Gu W, Zhao S, Shen Z, Lin Z, Liu W, Yan T (2022) Pharmacological activity of quercetin: an updated review. Evid Based Complement Alternat Med 2022:3997190
Wang S, Yu Z, Wang C, Wu C, Guo P, Wei J (2018b) Chemical constituents and pharmacological activity of agarwood and aquilaria plants. Molecules 23(2):342
Wang SL, Tsai YC, Fu SL, Cheng MJ, Chung MI, Chen JJ (2018c) 2-(2-Phenylethyl)-4H-chromen-4-one derivatives from the resinous wood of aquilaria sinensis with anti-inflammatory effects in LPS-induced macrophages. Molecules 23(2):289
Wani JA, Majid S, Imtiyaz Z, Rehman MU, Alsaffar RM, Shah NN, Alshehri S, Ghoneim MM, Imam SS (2022) MiRNAs in lung cancer: diagnostic, prognostic, and therapeutic potential. Diagnostics (Basel) 12(7):1610
Weng MS, Chang JH, Hung WY, Yang YC, Chien MH (2018) The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance. J Exp Clin Cancer Res 37(1):61
Whittle JR, Lickliter JD, Gan HK, Scott AM, Simes J, Solomon BJ, MacDiarmid JA, Brahmbhatt H, Rosenthal MA (2015) First in human nanotechnology doxorubicin delivery system to target epidermal growth factor receptors in recurrent glioblastoma. J Clin Neurosci 22(12):1889–1894
Wilchesky M, Ernst P, Brophy JM, Platt RW, Suissa S (2012) Bronchodilator use and the risk of arrhythmia in COPD: part 2: reassessment in the larger Quebec cohort. Chest 142(2):305–311
Wong YF, Chin ST, Perlmutter P, Marriott PJ (2015) Evaluation of comprehensive two-dimensional gas chromatography with accurate mass time-of-flight mass spectrometry for the metabolic profiling of plant-fungus interaction in Aquilaria malaccensis. J Chromatogr A 1387:104–115
Wong MCS, Lao XQ, Ho KF, Goggins WB, Tse SLA (2017) Incidence and mortality of lung cancer: global trends and association with socioeconomic status. Sci Rep 7(1):14300
Wu L, Zhang J, Qu JM, Bai CX, Merrilees MJ (2017) Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA. Int J Chron Obstruct Pulmon Dis 12:267–273
Wu X, Song L, Chen X, Zhang Y, Li S, Tang X (2022) Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1. Exp Cell Res 421(2):113390
Xiao Z, Jia S, Bao H, Niu Y, Ke Q, Kou X (2021) Protection of agarwood essential oil aroma by nanocellulose-graft-polylactic acid. Int J Biol Macromol 183:743–752
Xie M, Liu X, Cao X, Guo M, Li X (2020) Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017. Respir Res 21(1):49
Xu D, Wan C, Wang T, Tian P, Li D, Wu Y, Fan S, Chen L, Shen Y, Wen F (2015) Berberine attenuates cigarette smoke-induced airway inflammation and mucus hypersecretion in mice. Int J Clin Exp Med 8(6):8641–8647
Xu H, Li X, Kong H, Zeng X, Jin Y, Qi Y, Wang H, Xie W (2016) Characterization of the uptake efficiency and cytotoxicity of tetrandrine-loaded Poly(N-vinylpyrrolidone)-block-poly(ε-caprolactone) (PVP-b-PCL) nanoparticles in the A549 lung adenocarcinoma cell line. J Biomed Nanotechnol 12(8):1699–1707
Xu S, Zheng L, Kang L, Xu H, Gao L (2021) microRNA-let-7e in serum-derived exosomes inhibits the metastasis of non-small-cell lung cancer in a SUV39H2/LSD1/CDH1-dependent manner. Cancer Gene Ther 28(3–4):250–264
Xu YR, Wang AL, Li YQ (2022) Hypoxia-inducible factor 1-alpha is a driving mechanism linking chronic obstructive pulmonary disease to lung cancer. Front Oncol 12:984525
Xu M, Zhang L, Guo Y, Bai L, Luo Y, Wang B, Kuang M, Liu X, Sun M, Wang C, Xie J (2022) Nanoemulsion co-loaded with XIAP siRNA and gambogic acid for inhalation therapy of lung cancer. Int J Mol Sci 23. https://doi.org/10.3390/ijms232214294
Yang L, Zhang Z, Hou J, Jin X, Ke Z, Liu D, Du M, Jia X, Lv H (2017) Targeted delivery of ginsenoside compound K using TPGS/PEG-PCL mixed micelles for effective treatment of lung cancer. Int J Nanomedicine 12:7653–7667
Yang Y, Han Y, Sun Q, Cheng J, Yue C, Liu Y, Song J, Jin W, Ding X, de la Fuente JM, Ni J, Wang X, Cui D (2021) Au-siRNA@ aptamer nanocages as a high-efficiency drug and gene delivery system for targeted lung cancer therapy. J Nanobiotechnol 19(1):54
Yazbeck V, Alesi E, Myers J, Hackney MH, Cuttino L, Gewirtz DA (2022) An overview of chemotoxicity and radiation toxicity in cancer therapy. Adv Cancer Res 155:1–27
Ye H, He X, Feng X (2020) Developing neobavaisoflavone nanoemulsion suppresses lung cancer progression by regulating tumor microenvironment. Biomed Pharmacother 129:110369
Yin J, Xing H, Ye J (2008) Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 57(5):712–717
Yin HT, Zhang DG, Wu XL, Huang XE, Chen G (2013) In vivo evaluation of curcumin-loaded nanoparticles in a A549 xenograft mice model. Asian Pac J Cancer Prev 14(1):409–412
Yoo J, Park C, Yi G, Lee D, Koo H (2019) Active targeting strategies using biological ligands for nanoparticle drug delivery systems. Cancers (Basel) 11(5):640
Youlden DR, Cramb SM, Baade PD (2008) The International Epidemiology of Lung Cancer: geographical distribution and secular trends. J Thorac Oncol 3(8):819–831
Young RP, Hopkins RJ, Christmas T, Black PN, Metcalf P, Gamble GD (2009) COPD prevalence is increased in lung cancer, independent of age, sex and smoking history. Eur Respir J 34(2):380–386
Yousefian Rad E, Homayouni Tabrizi M, Ardalan P, Seyedi SMR, Yadamani S, Zamani-Esmati P, Haghani Sereshkeh N (2020) Citrus lemon essential oil nanoemulsion (CLEO-NE), a safe cell-depended apoptosis inducer in human A549 lung cancer cells with anti-angiogenic activity. J Microencapsul 37(5):394–402
Yu H, Zou Y, Jiang L, Yin Q, He X, Chen L, Zhang Z, Gu W, Li Y (2013) Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles. Biomaterials 34(11):2738–2747
Yu Q, Yang D, Chen X, Chen Q (2019) CD147 increases mucus secretion induced by cigarette smoke in COPD. BMC Pulm Med 19(1):29
Yusen RD (2013) Evolution of the GOLD documents for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Controversies and questions. Am J Respir Crit Care Med 188(1):4–5
Zarogoulidis P, Eleftheriadou E, Sapardanis I, Zarogoulidou V, Lithoxopoulou H, Kontakiotis T, Karamanos N, Zachariadis G, Mabroudi M, Zisimopoulos A, Zarogoulidis K (2012) Feasibility and effectiveness of inhaled carboplatin in NSCLC patients. Invest New Drugs 30(4):1628–1640
Zhang D, Lee H, Wang X, Rai A, Groot M, Jin Y (2018) Exosome-mediated small RNA delivery: a novel therapeutic approach for inflammatory lung responses. Mol Ther 26(9):2119–2130
Zhang G, Xie F, Sun Y, Yu X, Xiao Z, Fang R, Li J, Li Q, Du L, Jin Y (2021) Inhalable jojoba oil dry nanoemulsion powders for the treatment of lipopolysaccharide- or H(2)O(2)-induced acute lung injury. Pharmaceutics 13(4):486
Zhang H, Wang X, Dai W, Gemeinhart RA, Zhang Q, Li T (2014) Pharmacokinetics and treatment efficacy of camptothecin nanocrystals on lung metastasis. Mol Pharm 11(1):226–233
Zhang HL, Zhang ZX, Xu YJ (2004) The effects of nuclear factor kappa B decoy oligodeoxynucleotides on ciglitazone-induced differentiation of lung cancer cells A549. Zhonghua Nei Ke Za Zhi 43(3):201–204
Zhang T, Chen Y, Ge Y, Hu Y, Li M, Jin Y (2018) Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers. Acta Pharm Sin B 8(3):440–448
Zhang W, Xu W, Lan Y, He X, Liu K, Liang Y (2019) Antitumor effect of hyaluronic-acid-modified chitosan nanoparticles loaded with siRNA for targeted therapy for non-small cell lung cancer. Int J Nanomedicine 14:5287–5301
Zhang X, Zhang J, Wang L, Wei H, Tian Z (2007) Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice. BMC Cancer 7:149
Zhang X, Zhang J, Wei H, Tian Z (2007) STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncol Rep 17(6):1377–1382
Zhang Y, Huang Y, Li S (2014) Polymeric micelles: nanocarriers for cancer-targeted drug delivery. AAPS PharmSciTech 15(4):862–871
Zhao H, Lu H, Gong T, Zhang Z (2013) Nanoemulsion loaded with lycobetaine-oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation, and antitumor activity. Int J Nanomedicine 8:1959–1973
Zhao MH, Yuan L, Meng LY, Qiu JL, Wang CB (2017) Quercetin-loaded mixed micelles exhibit enhanced cytotoxic efficacy in non-small cell lung cancer in vitro. Exp Ther Med 14(6):5503–5508
Zhao X, He X, Wang M, Zhang H, Cheng J, Wang H (2022) IncRNA PLAC2 Upregulates CDK6 by directly targeting miR-29C to promote cell proliferation in lung squamous cell carcinoma. Crit Rev Eukaryot Gene Expr 32(8):55–67
Zheng F, Tang Q, Wu J, Zhao S, Liang Z, Li L, Wu W, Hann S (2014) p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine. J Exp Clin Cancer Res 33(1):36
Zhong Y, Ding X, Bian Y, Wang J, Zhou W, Wang X, Li P, Shen Y, Wang JJ, Li J, Zhang C, Wang C (2021) Discovery and validation of extracellular vesicle-associated miRNAs as noninvasive detection biomarkers for early-stage non-small-cell lung cancer. Mol Oncol 15(9):2439–2452
Zhou X, Liu HY, Zhao H, Wang T (2018) RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment. Onco Targets Ther 11:5397–5405
Zhu JJ, Zhang XX, Miao YQ, He SF, Tian DM, Yao XS, Tang JS, Gan Y (2017) Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells. Acta Pharmacol Sin 38(2):290–300
Zhu WT, Liu SY, Wu L, Xu HL, Wang J, Ni GX, Zeng QB (2017) Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer. Int J Nanomedicine 12:2621–2634
Zhuang M, Jiang S, Gu A, Chen X, Mingyan E (2021) Radiosensitizing effect of gold nanoparticle loaded with small interfering RNA-SP1 on lung cancer: AuNPs-si-SP1 regulates GZMB for radiosensitivity. Transl Oncol 14(12):101210
Zolnik BS, González-Fernández A, Sadrieh N, Dobrovolskaia MA (2010) Nanoparticles and the immune system. Endocrinology 151(2):458–465
Zoulikha M, Xiao Q, Boafo GF, Sallam MA, Chen Z, He W (2022) Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome. Acta Pharm Sin B 12(2):600–620
Funding
Kamal Dua is supported by a project grant from the Rebecca L. Cooper Medical Research Foundation and the Maridulu Budyari Gumal Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) Triple I Seed grant, RSEOH CAG Seed grant, fellowship, and extension grant; Faculty of Health MCR/ECR Mentorship Support Grant and UTS Global Strategic Partnerships Seed Funding Scheme. Gabriele De Rubis is supported by the Triple I Clinical Academic Group (CAG) Secondment/Exchange Program grant. Keshav Raj Paudel is supported by a fellowship from Prevent Cancer Foundation (PCF) and the International Association for the Study of Lung Cancer (IASLC). Kamal Dua, Keshav Raj Paudel, and Gabriele De Rubis are also supported by UTS 2023 Key Technology Partner (KTP) grants.
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GDR and KD conceived the idea of the literature review. All the listed authors contributed to the writing of the first draft of the manuscript and to the subsequent revisions and finalisation of the manuscript. KD supervised the project. The authors confirm that no paper mill and artificial intelligence was used.
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De Rubis, G., Paudel, K.R., Corrie, L. et al. Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease. Naunyn-Schmiedeberg's Arch Pharmacol 397, 2793–2833 (2024). https://doi.org/10.1007/s00210-023-02830-w
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DOI: https://doi.org/10.1007/s00210-023-02830-w