Abstract
Plant-based functional foods have gained wider attention in current scenario with mung bean harboring several bioactive compounds with promising gut health benefits and pharmacological importance. Consumption of mung bean has a positive impact on beneficial gut microbes and microbial metabolite production. The effects of dietary mung bean on gut microbial homeostasis and the management of gut-related diseases along with the possible mechanism of action, have been highlighted through this review paving a way for a promising role of dietary mung bean as a functional food in the management of gut-related diseases for example mung bean peptides can help not only in treating prediabetes but also delaying the aging process by targeting the intestinal microflora. In addition, expanding our knowledge of how diets affect host health and disease, including the effects of mung bean dietary components on gut microbiota-derived metabolites, will eventually allow for the development of tailored diets and nutrients.
Similar content being viewed by others
References
Aurigemma NC, Koltun KJ, VanEvery H, Rogers CJ, De Souza MJ. Linking the gut microbiota to bone health in anorexia nervosa. Current Osteoporosis Reports. 16: 65-75 (2018)
Cani PD. Human gut microbiome: hopes, threats and promises. Gut. 67: 1716-1725 (2018)
Carding S, Verbeke K, Vipond DT, Corfe BM, Owen LJ. Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health and Disease. 26: 26191 (2015)
Charoensiddhi S, Chanput WP, Sae-Tan S. Gut microbiota modulation, anti-diabetic and anti inflammatory properties of polyphenol extract from mung bean seed coat (Vigna radiata L.). Nutrients. 14: 2275 (2022)
Claesson MJ, Jeffery IB, Conde S, Power SE, O’connor EM, Cusack S, Harris H, Coakley M, Lakshminarayanan B, O’sullivan O, Fitzgerald GF. Gut microbiota composition correlates with diet and health in the elderly. Nature. 488: 178-184 (2012)
Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of environmental pollutants? NPJ Biofilms Microbiomes. 3: 17001 (2017)
Derrien M, Veiga P. Rethinking diet to aid human–microbe symbiosis. Trends in Microbiology. 25: 100-112 (2017)
Esgalhado M, Kemp JA, Damasceno NR, Fouque D, Mafra D. Short-chain fatty acids: a link between prebiotics and microbiota in chronic kidney disease. Future Microbiology. 12: 1413-1425 (2017)
Hou D, Yousaf L, Xue Y, Hu J, Wu J, Hu X, Feng N, Shen Q. Mung bean (Vigna radiata L.): bioactive polyphenols, polysaccharides, peptides, and health benefits. Nutrients. 11: 1238 (2019)
Hou D, Zhao Q, Yousaf L, Chen B, Xue Y, Shen Q. A comparison between whole mung bean and decorticated mung bean: beneficial effects on the regulation of serum glucose and lipid disorders and the gut microbiota in high-fat diet and streptozotocin-induced prediabetic mice. Food Function. 11: 5525-5537 (2020)
Hou D, Zhao Q, Chen B, Ren X, Yousaf L, Shen Q. Dietary supplementation with mung bean coat alleviates the disorders in serum glucose and lipid profile and modulates gut microbiota in high‐fat diet and streptozotocin‐induced prediabetic mice. Journal of Food Science. 86: 4183-4196 (2021)
Hou D, Tang J, Huan M, Liu F, Zhou S, Shen Q. Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice. Food Science and Human Wellness. 11: 1259-1272 (2022)
Jang YH, Kang MJ, Choe EO, Shin M, Kim JI. Mung bean coat ameliorates hyperglycemia and the antioxidant status in type 2 diabetic db/db mice. Food Science and Biotechnology. 23: 247-252 (2014)
Ketha K, Gudipati M. Immunomodulatory activity of non starch polysaccharides isolated from green gram (Vigna radiata). Food Research International. 113: 269-276 (2018)
Ladurner A, Schachner D, Schueller K, Pignitter M, Heiss EH, Somoza V, Dirsch VM. Impact of trans-resveratrol-sulfates and-glucuronides on endothelial nitric oxide synthase activity, nitric oxide release and intracellular reactive oxygen species. Molecules. 19: 16724-16736 (2014)
Laparra JM, Sanz Y. Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacological Research Communications. 61: 219-225 (2010)
Li L, Tian Y, Zhang S, Feng Y, Wang H, Cheng X, Ma Y, Zhang R, Wang C. Regulatory effect of mung bean peptide on prediabetic mice induced by high-fat diet. Frontiers in Nutrition. 9: 913016 (2022)
Loo YT, Howell K, Chan M, Zhang P, Ng K. Modulation of the human gut microbiota by phenolics and phenolic fiber‐rich foods. Comprehensive Reviews in Food Science and Food Safety. 19: 1268-1298 (2020)
Morgan XC, Huttenhower C. Human microbiome analysis. PLOS Computational Biology. 8: e1002808 (2012)
Nakatani A, Li X, Miyamoto J, Igarashi M, Watanabe H, Sutou A, Watanabe K, Motoyama T, Tachibana N, Kohno M, Inoue H. Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner. Biochemical and Biophysical Research Communications. 501: 955-961 (2018)
Nugues MM, Roberts CM. Coral mortality and interaction with algae in relation to sedimentation. Coral Reefs. 22: 507-516 (2003)
Pickard JM, Zeng MY, Caruso R, Núñez G. Gut microbiota: role in pathogen colonization, immune responses, and inflammatory disease. Immunological Reviews. 279: 70-89 (2017)
Rajpoot M, Sharma AK, Sharma A, Gupta GK. Understanding the microbiome: emerging biomarkers for exploiting the microbiota for personalized medicine against cancer. Seminars in Cancer Biology. 1:1-8 (2018)
Rajpoot M, Bhattacharya R, Sharma S, Gupta S, Sharma V, Sharma AK. Melamine contamination and associated health risks: gut microbiota does make a difference. Biotechnology and Applied Biochemistry. 68: 1271-1280 (2021)
Ray SK, Mukherjee S. Evolving interplay between dietary polyphenols and gut microbiota—an emerging importance in healthcare. Frontiers in Nutrition. 8: 634944 (2021)
Salonen A, de Vos WM. Impact of diet on human intestinal microbiota and health. Annual Review of Food Science and Technology. 5: 239-262 (2014)
Sarkar A, Harty S, Lehto SM, Moeller AH, Dinan TG, Dunbar RI, Cryan JF, Burnet PW. The microbiome in psychology and cognitive neuroscience. Trends in Cognitive Sciences. 22: 611-636 (2018)
Sehrawat N, Yadav M, Kumar S, Upadhyay SK, Singh M, Sharma AK. Review on health promoting biological activities of mungbean: a potent functional food of medicinal importance. Plant Archives. 20: 2969-2975 (2020)
Sehrawat N, Yadav M, Singh M, Kumar V, Sharma VR, Sharma AK. Probiotics in microbiome ecological balance providing a therapeutic window against cancer. Seminars in Cancer Biology. 24-36 (2021a)
Selber-Hnatiw S, Rukundo B, Ahmadi M, Akoubi H, Al-Bizri H, Aliu AF, Ambeaghen TU, Avetisyan L, Bahar I, Baird A, Begum F. Human gut microbiota: toward an ecology of disease. Frontiers in Microbiology. 8: 1265 (2017)
Sharma V, Sankhyan A, Varshney A, Choudhary R, Sharma AK. Current paradigms to explore the gut microbiota linkage to neurological disorders. Neurology. 8: 68-79 (2020)
Sharma VR, Singh M, Kumar V, Yadav M, Sehrawat N, Sharma DK, Sharma AK. Microbiome dysbiosis in cancer: exploring therapeutic strategies to counter the disease. Seminars in Cancer Biology. 61-70 (2021)
Shen CY, Hao YF, Hao ZX, Liu Q, Zhang L, Jiang CP, Jiang JG. Flavonoids from Rosa davurica pall fruits prevent high-fat diet-induced obesity and liver injury via modulation of the gut microbiota in mice. Food & Function. 12: 10097-10106 (2021)
Shen X, Jiang X, Qian L, Zhang A, Zuo F, Zhang D. Polyphenol extracts from germinated mung beans can improve type 2 diabetes in mice by regulating intestinal microflora and inhibiting inflammation. Frontiers in Nutrition. 9: 846409 (2022)
Sigwela V, De Wit M, du Toit A, Osthoff G, Hugo A. Bioactive betalain extracts from cactus pear fruit pulp, beetroot tubers, and amaranth leaves. Molecules. 26: 5012 (2021)
Sonnenburg JL, Bäckhed F. Diet–microbiota interactions as moderators of human metabolism. Nature. 535: 56-64 (2016)
Tomova A, Bukovsky I, Rembert E, Yonas W, Alwarith J, Barnard ND, Kahleova H. The effects of vegetarian and vegan diets on gut microbiota. Frontiers in Nutrition. 6: 47 (2019)
Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. British Medical Journal. 361 (2018)
Vamanu E, Gatea F, Avram I, Radu GL, Singh SK. Dysbiotic gut microbiota modulation by aronia fruits extract administration. Life. 13: 32 (2022)
Van Immerseel F, Ducatelle R, De Vos M, Boon N, Van De Wiele T, Verbeke K, Rutgeerts P, Sas B, Louis P, Flint HJ. Butyric acid-producing anaerobic bacteria as a novel probiotic treatment approach for inflammatory bowel disease. Microbiology Society. 59:141-143 (2010)
Wang T, Han Y, Li H, Wang Y, Chen X, Chen W, Qiu X, Gong J, Li W, Zhu T. Proinflammatory lipid signals trigger the health effects of air pollution in individuals with prediabetes. Environmental Pollution. 290: 118008 (2021)
Wei Z, Wang Y, Shi Z, Zhou N, Ren G, Hao X, Zou L, Yao Y. Mung bean protein suppresses undernutrition-induced growth deficits and cognitive dysfunction in rats via gut microbiota-TLR4/NF-kB pathway. Journal of Agricultural and Food Chemistry. 69: 12566-12577 (2021)
Xiao W, Zhang Q, Yu L, Tian F, Chen W, Zhai Q. Effects of vegetarian diet-associated nutrients on gut microbiota and intestinal physiology. Food Science and Human Wellness. 11: 208-217 (2022)
Xie J, Song Q, Yu Q, Chen Y, Hong Y, Shen M. Dietary polysaccharide from mung bean [Vigna radiate (Linn.) Wilczek] skin modulates gut microbiota and short‐chain fatty acids in mice. International Journal of Food Science. 57: 2581-2589 (2022a)
Xie J, Sun N, Huang H, Xie J, Chen Y, Hu X, Hu X, Dong R, Yu Q. Catabolism of polyphenols released from mung bean coat and its effects on gut microbiota during in vitro simulated digestion and colonic fermentation. Food Chemistry. 396: 133719 (2022b)
Yang QQ, Ge YY, Gunaratne A, Kong KW, Li HB, Gul K, Kumara K, Arachchi LV, Zhu F, Corke H, Gan RY. Phenolic profiles, antioxidant activities, and antiproliferative activities of different mung bean (Vigna radiata) varieties from Sri Lanka. Food Bioscience. 37: 100705 (2020)
Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB. Impacts of gut bacteria on human health and diseases. International Journal of Molecular Sciences. 16: 7493-7519 (2015)
Zhang S, Ma YT, Feng YC, Wang CY, Zhang DJ. Potential effects of mung bean protein and a mung bean protein–polyphenol complex on oxidative stress levels and intestinal microflora in aging mice. Food & Function. 13: 186-197 (2022)
Zhang S, Wang CA, Liu S, Wang Y, Lu S, Han S, Jiang H, Liu H, Yang Y. Effect of dietary phenylalanine on growth performance and intestinal health of triploid rainbow trout (Oncorhynchus mykiss) in low fishmeal diets. Frontiers in Nutrition. 10: 1008822 (2023)
Zhao Q, Fu Y, Zhang F, Wang C, Yang X, Bai S, Xue Y, Shen Q. Heat‐treated adzuki bean protein hydrolysates reduce obesity in mice fed a high‐fat diet via remodeling gut microbiota and improving metabolic function. Molecular Nutrition & Food Research. 66: 2100907 (2022)
Acknowledgements
Authors (MY, NS and AKS) acknowledge the help and support by Head, Department of Bio-Sciences and Technology, MMEC, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, India. KD, SCC, DC, SC and AD acknowledge their respective Institutes as well.
Funding
No funding was received for the said manuscript.
Author information
Authors and Affiliations
Contributions
MY, NS did most of the writing part and making figures. VS made the table and helped in designing figures as well. KD, DC, AD, SC, SCC were involved in planning, updating, fine tuning, critical editing and reviewing; AKS was involved in conceptualization, analysis, supervision along with concluding the manuscript. All the authors reviewed the manuscript critically.
Corresponding authors
Ethics declarations
Conflict of Interest
Authors declare no conflict of interest.
Ethical approval
Not applicable.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Sehrawat, N., Yadav, M., Sharma, A.K. et al. Dietary mung bean as promising food for human health: gut microbiota modulation and insight into factors, regulation, mechanisms and therapeutics—an update. Food Sci Biotechnol 33, 2035–2045 (2024). https://doi.org/10.1007/s10068-023-01495-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10068-023-01495-8