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Spatial patterns and frequency distributions of regional deformation in the healthy human lung

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Abstract

Understanding regional deformation in the lung has long attracted the medical community, as parenchymal deformation plays a key role in respiratory physiology. Recent advances in image registration make it possible to noninvasively study regional deformation, showing that volumetric deformation in healthy lungs follows complex spatial patterns not necessarily shared by all subjects, and that deformation can be highly anisotropic. In this work, we systematically study the regional deformation in the lungs of eleven human subjects by means of in vivo image-based biomechanical analysis. Regional deformation is quantified in terms of 3D maps of the invariants of the right stretch tensor, which are related to regional changes in length, surface and volume. Based on the histograms of individual lungs, we show that log-normal distributions adequately represent the frequency distribution of deformation invariants in the lung, which naturally motivates the normalization of the invariant fields in terms of the log-normal score. Normalized maps of deformation invariants allow for a direct intersubject comparison, as they display spatial patterns of deformation in a range that is common to all subjects. For the population studied, we find that lungs in supine position display a marked gradient along the gravitational direction not only for volumetric but also for length and surface regional deformation, highlighting the role of gravity in the regional deformation of normal lungs under spontaneous breathing.

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Acknowledgements

This study was funded by the Pontificia Universidad Católica de Chile through the VRI Concurso Puente P1614.

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Authors and Affiliations

  1. Department of Structural and Geotechnical Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

    Daniel E. Hurtado, Nicolás Villarroel & Carlos Andrade

  2. Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago, Chile

    Daniel E. Hurtado

  3. Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 367, Santiago, Chile

    Jaime Retamal, Guillermo Bugedo & Alejandro Bruhn

  4. Hedenstierna Laboratory, Department of Surgical Science, Uppsala University, Uppsala, Sweden

    Jaime Retamal

Authors
  1. Daniel E. Hurtado
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  2. Nicolás Villarroel
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  3. Carlos Andrade
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  4. Jaime Retamal
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Correspondence to Daniel E. Hurtado.

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Hurtado, D.E., Villarroel, N., Andrade, C. et al. Spatial patterns and frequency distributions of regional deformation in the healthy human lung. Biomech Model Mechanobiol 16, 1413–1423 (2017). https://doi.org/10.1007/s10237-017-0895-5

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  • DOI: https://doi.org/10.1007/s10237-017-0895-5

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