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A general pattern of non-spiking neuron dynamics under the effect of potassium and calcium channel modifications

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Abstract

Electrical activity of excitable cells results from ion exchanges through cell membranes, so that genetic or epigenetic changes in genes encoding ion channels are likely to affect neuronal electrical signaling throughout the brain. There is a large literature on the effect of variations in ion channels on the dynamics of spiking neurons that represent the main type of neurons found in the vertebrate nervous systems. Nevertheless, non-spiking neurons are also ubiquitous in many nervous tissues and play a critical role in the processing of some sensory systems. To our knowledge, however, how conductance variations affect the dynamics of non-spiking neurons has never been assessed. Based on experimental observations reported in the biological literature and on mathematical considerations, we first propose a phenotypic classification of non-spiking neurons. Then, we determine a general pattern of the phenotypic evolution of non-spiking neurons as a function of changes in calcium and potassium conductances. Furthermore, we study the homeostatic compensatory mechanisms of ion channels in a well-posed non-spiking retinal cone model. We show that there is a restricted range of ion conductance values for which the behavior and phenotype of the neuron are maintained. Finally, we discuss the implications of the phenotypic changes of individual cells at the level of neuronal network functioning of the C. elegans worm and the retina, which are two non-spiking nervous tissues composed of neurons with various phenotypes.

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The code used in this paper is available at https://gitlab.com/lois76/conductance_nonspikingneurons_code.

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Acknowledgements

We thank Dr. Mellem and Dr. Liu for their consents to reproduce their experimental data.

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  1. Laboratoire Lorrain de Recherche en Informatique et ses Applications, CNRS, Université de Lorraine, Nancy, France

    Loïs Naudin, Laetitia Raison-Aubry & Laure Buhry

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  1. Loïs Naudin
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Naudin, L., Raison-Aubry, L. & Buhry, L. A general pattern of non-spiking neuron dynamics under the effect of potassium and calcium channel modifications. J Comput Neurosci 51, 173–186 (2023). https://doi.org/10.1007/s10827-022-00840-w

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