Abstract
In recent years, antibiotic-conjugated nanoparticles have attracted great interest for use as antimicrobial agents. Unfortunately, most of antibiotic-conjugated nanocomposites are involved in a multi-step and time-consuming process. Herein, we developed a vancomycin-encapsulated ZIF-8 (VAN@ZIF-8) nanoparticles by a simple one-pot approach to combat bacteria. The prepared VAN@ZIF-8 nanoparticles have the capacity to recognize gram-positive bacteria because of the strong and specific five-hydrogen bond between the VAN and the D-alanyl-D-alanine dipeptide coming from gram-positive bacteria cell wall. Importantly, owing to the multivalent nanoparticle-bacterium interactions, the VAN-encapsulated ZIF-8 nanoparticles exhibit a higher antibacterial efficacy in gram-positive bacteria compared to the free VAN molecules. In addition, the VAN@ZIF-8 nanoparticles as photocatalysts also show a strong photoinactivation of the bacteria under light irradiation. The present study is of interest for opening up tremendous opportunities to make good use of ZIF-8 and other MOFs in applications to combat bacteria, because of their excellent antibacterial activity and facile preparation method.
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Acknowledgements
We thank the National Natural Science Foundation of China (No. 21703255) the Natural Science Foundation of Anhui Province (Nos. 1908085MB47, 1708085MB35), the Key Projects of Anhui Province University Outstanding Youth Talent Support Program (No. gxyqZD2018021) and the Research Fund for the Doctoral Program of Anhui Medical University (No. XJ201808) for the financial support.
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Hao, C., Zhou, D., Xu, J. et al. One-pot synthesis of vancomycin-encapsulated ZIF-8 nanoparticles as multivalent and photocatalytic antibacterial agents for selective-killing of pathogenic gram-positive bacteria. J Mater Sci 56, 9434–9444 (2021). https://doi.org/10.1007/s10853-021-05828-y
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DOI: https://doi.org/10.1007/s10853-021-05828-y