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Natural nanoporous silica frustules from marine diatom as a biocarrier for drug delivery

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Abstract

The possible use of natural silica nanoporous biomaterial from marine diatom for drug delivery applications was explored. Coscinodiscus concinnus have a homogeneous size distribution with radius of 220 ± 15 µm with surface featuring a mounded topography with about 2 µm wide porous domes organized on the surface in pentagonal packing. Streptomycin, used as a hydrophilic drug to demonstrate the in vitro oral drug delivery model based on diatom structure, mainly adsorbed on to the diatom silica surface (foramen), inside pores (cribrum) and into the internal hollow diatom structure (cribellum). The maximum drug loading capacity of streptomycin was 33.33 ± 2 %. The release was biphasic, involving initial burst release (first 6 h) mainly from the surface of diatom foramen, and sustained drug release (upto 7 days) from cribrum and cribellum. The study indicated that the live diatoms from marine environment, due to their unique features (easy cultivable, low-cost and biocompatibility), are a potential and alternative natural source of nanoporous siliceous material for in vitro oral drug delivery applications.

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Acknowledgments

We would like to thank Annamalai University authorities for support, and this work was supported by funding under fast track project file no: SERB/F/5582/2012-13 from Science and Engineering Research Board (SERB), Department of Science and Technology, New Delhi.

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Authors and Affiliations

  1. Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, 608 502, Tamil nadu, India

    P. Gnanamoorthy, S. Anandhan & V. Ashok Prabu

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  1. P. Gnanamoorthy
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  2. S. Anandhan
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  3. V. Ashok Prabu
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Correspondence to P. Gnanamoorthy.

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Gnanamoorthy, P., Anandhan, S. & Prabu, V.A. Natural nanoporous silica frustules from marine diatom as a biocarrier for drug delivery. J Porous Mater 21, 789–796 (2014). https://doi.org/10.1007/s10934-014-9827-2

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