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Functions of RNA N6-methyladenosine modification in cancer progression

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A Publisher Correction to this article was published on 14 July 2023

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Abstract

N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.

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Acknowledgements

We thank the PubMed database and its contributors for this valuable public data set. We also thank Dr Menglong Zhao from Dutch Institute for Fundamental Energy Research for helping to edit this manuscript.

Funding

This work was supported by the Key Project of Scientific Research Foundation for Colleges and Universities in Henan Province (Grant No. 16A320081) and National Natural Science Foundation of China (Grant No. 81802325).

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  1. Bing Chen and Ya Li have contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People’s Republic of China

    Bing Chen, Ya Li, Ruifeng Song & Feng Xu

  2. Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Eastern Road, Zhengzhou, 450052, People’s Republic of China

    Chen Xue

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  1. Bing Chen
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Chen, B., Li, Y., Song, R. et al. Functions of RNA N6-methyladenosine modification in cancer progression. Mol Biol Rep 46, 2567–2575 (2019). https://doi.org/10.1007/s11033-019-04655-4

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