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Accuracy analysis in MRI-guided robotic prostate biopsy

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose

To assess retrospectively the clinical accuracy of an magnetic resonance imaging-guided robotic prostate biopsy system that has been used in the US National Cancer Institute for over 6 years.

Methods

Series of 2D transverse volumetric MR image slices of the prostate both pre (high-resolution T2-weighted)- and post (low-resolution)- needle insertions were used to evaluate biopsy accuracy. A three-stage registration algorithm consisting of an initial two-step rigid registration followed by a B-spline deformable alignment was developed to capture prostate motion during biopsy. The target displacement (distance between planned and actual biopsy target), needle placement error (distance from planned biopsy target to needle trajectory), and biopsy error (distance from actual biopsy target to needle trajectory) were calculated as accuracy assessment.

Results

A total of 90 biopsies from 24 patients were studied. The registrations were validated by checking prostate contour alignment using image overlay, and the results were accurate to within 2 mm. The mean target displacement, needle placement error, and clinical biopsy error were 5.2, 2.5, and 4.3 mm, respectively.

Conclusion

The biopsy error reported suggests that quantitative imaging techniques for prostate registration and motion compensation may improve prostate biopsy targeting accuracy.

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Acknowledgments

This work is supported by: US National Institutes of Health (NIH) 5R01CA111288-04 and 5R01EB002963-05, Canadian Ontario Graduate Scholarship (OGS), and Applied Cancer Research Unit program of Cancer Care Ontario with funds provided by the Ontario Ministry of Health and Long-Term Care. Gabor Fichtinger was funded as a Cancer Ontario Research Chair. Conflict of interest    None.

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Authors and Affiliations

  1. Queen’s University, Kingston, ON, Canada

    Helen Xu, Andras Lasso & Gabor Fichtinger

  2. National Institutes of Health, Bethesda, MD, USA

    Peter Guion, Aradhana Kaushal & Peter A. Pinto

  3. Children’s National Medical Center, Washington, DC, USA

    Axel Krieger

  4. Rosewell Park Cancer Institute, Buffalo, NY, USA

    Anurag K. Singh

  5. Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Jonathan Coleman

  6. Washington University in St. Louis, St. Louis, MO, USA

    Robert L. Grubb III

  7. Centre Hospitalier de L’Universite de Montreal, Montreal, QC, Canada

    Jean-Baptiste Lattouf

  8. Princess Margaret Hospital, Toronto, ON, Canada

    Cynthia Menard

  9. Johns Hopkins University, Baltimore, MD, USA

    Louis L. Whitcomb & Gabor Fichtinger

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  1. Helen Xu
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  2. Andras Lasso
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Corresponding author

Correspondence to Helen Xu.

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Xu, H., Lasso, A., Guion, P. et al. Accuracy analysis in MRI-guided robotic prostate biopsy. Int J CARS 8, 937–944 (2013). https://doi.org/10.1007/s11548-013-0831-9

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  • DOI: https://doi.org/10.1007/s11548-013-0831-9

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