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Structural changes in the hippocampus and amygdala at first episode of psychosis

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Abstract

Hippocampus and amygdala changes have been implicated in the pathophysiology and symptomatology of both schizophrenia (SCZ) and bipolar disorder (BD). However relationships between illness course, neuropathological changes and variations in symptomatology remain unclear. This investigation examined the associations between hippocampus and amygdala volumes and symptom dimensions in schizophrenia and bipolar disorder patients after their first episode of psychosis. Symptom severity was associated with decreases in hippocampus/amygdala complex volume across groups. In keeping with previous work bilateral hippocampus and amygdala volume reductions were also identified in the SCZ patients while in BD patients only evidence of amygdala inflation reached significance. The study concludes that there appear to be important relationships between volume changes in the hippocampus and amygdala and dimensions and severity of symptomatology in psychosis. Structural alterations are apparent in both SCZ and BD after first episode of psychosis but present differently in each illness and are more severe in SCZ.

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References

  • Achim, A. M., & Lepage, M. (2005). Episodic memory-related activation in schizophrenia: meta-analysis. The British Journal of Psychiatry: The Journal of Mental Science, 187, 500–509.

    Article  Google Scholar 

  • Addington, J., Saeedi, H., & Addington, D. (2006). Influence of social perception and social knowledge on cognitive and social functioning in early psychosis. The British Journal of Psychiatry: The Journal of Mental Science, 189, 373–378.

    Article  Google Scholar 

  • Aleman, A., & Kahn, R. S. (2005). Strange feelings: do amygdala abnormalities dysregulate the emotional brain in schizophrenia? Progress in Neurobiology, 77(5), 283–298.

    PubMed  Google Scholar 

  • Aleman, A., Hijman, R., de Haan, E. H., & Kahn, R. S. (1999). Memory impairment in schizophrenia: a meta-analysis. The American Journal of Psychiatry, 156(9), 1358–1366.

    PubMed  CAS  Google Scholar 

  • Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K., et al. (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48(2), 147–162.

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorder IV (text revision). Washington DC: Americam Psychiatric Association.

    Google Scholar 

  • Arnone, D., Cavanagh, J., Gerber, D., Lawrie, S. M., Ebmeier, K. P., & McIntosh, A. M. (2009). Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. The British Journal of Psychiatry: The Journal of Mental Science, 195(3), 194–201.

    Article  Google Scholar 

  • Barrett, S. L., Mulholland, C. C., Cooper, S. J., & Rushe, T. M. (2009). Patterns of neurocognitive impairment in first-episode bipolar disorder and schizophrenia. The British Journal of Psychiatry: The Journal of Mental Science, 195(1), 67–72.

    Article  Google Scholar 

  • Bebbington, P. E., & Nayani, T. (1995). The psychosis screening questionnaire. International Journal of Methods in Psychiatric Research, 5, 11–19.

    Google Scholar 

  • Benes, F. M. (2007). Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms. Schizophrenia Bulletin, 33(4), 932–936.

    Article  PubMed  Google Scholar 

  • Benes, F. M. (2010). Amygdalocortical circuitry in schizophrenia: from circuits to molecules. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 35(1), 239–257.

    Article  Google Scholar 

  • Berrettini, W. (2003). Bipolar disorder and schizophrenia: not so distant relatives? World Psychiatry: Official Journal of the World Psychiatric Association (WPA), 2(2), 68–72.

    Google Scholar 

  • Bilder, R. M., Wu, H., Bogerts, B., Degreef, G., Ashtari, M., Alvir, J. M., et al. (1994). Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. The American Journal of Psychiatry, 151(10), 1437–1447.

    PubMed  CAS  Google Scholar 

  • Bilder, R. M., Goldman, R. S., Robinson, D., Reiter, G., Bell, L., Bates, J. A., et al. (2000). Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates. The American Journal of Psychiatry, 157(4), 549–559.

    Article  PubMed  CAS  Google Scholar 

  • Blumberg, H. P., Kaufman, J., Martin, A., Whiteman, R., Zhang, J. H., Gore, J. C., et al. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry, 60(12), 1201–1208.

    Article  PubMed  Google Scholar 

  • Bogerts, B. (1997). The temporolimbic system theory of positive schizophrenic symptoms. Schizophrenia Bulletin, 23(3), 423–435.

    PubMed  CAS  Google Scholar 

  • Brambilla, P., Harenski, K., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E., et al. (2003). MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Research, 37(4), 287–295.

    Article  PubMed  Google Scholar 

  • Brambilla, P., Hatch, J. P., & Soares, J. C. (2008). Limbic changes identified by imaging in bipolar patients. Current Psychiatry Reports, 10(6), 505–509.

    Article  PubMed  Google Scholar 

  • Brierley, B., Shaw, P., & David, A. S. (2002). The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging. Brain Research. Brain Research Reviews, 39(1), 84–105.

    Article  PubMed  CAS  Google Scholar 

  • Buckner, R. L., Head, D., Parker, J., Fotenos, A. F., Marcus, D., Morris, J. C., et al. (2004). A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume. NeuroImage, 23(2), 724–738.

    Article  PubMed  Google Scholar 

  • Bullmore, E. T., Frangou, S., & Murray, R. M. (1997). The dysplastic net hypothesis: an integration of developmental and dysconnectivity theories of schizophrenia. Schizophrenia Research, 28(2–3), 143–156.

    Article  PubMed  CAS  Google Scholar 

  • Chance, S. A., Esiri, M. M., & Crow, T. J. (2002). Amygdala volume in schizophrenia: post-mortem study and review of magnetic resonance imaging findings. The British Journal of Psychiatry: The Journal of Mental Science, 180, 331–338.

    Article  Google Scholar 

  • Copolov, D., Velakoulis, D., McGorry, P., Carina, M., Yung, A., Rees, S., et al. (2000). Neurobiological findings in early phase schizophrenia. Brain Research. Brain Research Reviews, 31(2–3), 157–165.

    Article  PubMed  CAS  Google Scholar 

  • Crespo-Facorro, B., Barbadillo, L., Pelayo-Teran, J. M., & Rodriguez-Sanchez, J. M. (2007). Neuropsychological functioning and brain structure in schizophrenia. International Review of Psychiatry (Abingdon, England), 19(4), 325–336.

    Article  Google Scholar 

  • Crow, T. J. (1997). Schizophrenia as failure of hemispheric dominance for language. Trends in Neurosciences, 20(8), 339–343.

    Article  PubMed  CAS  Google Scholar 

  • DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004). Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorders, 6(1), 43–52.

    Article  PubMed  Google Scholar 

  • Dickerson, F., Boronow, J. J., Stallings, C., Origoni, A. E., Cole, S. K., & Yolken, R. H. (2004). Cognitive functioning in schizophrenia and bipolar disorder: comparison of performance on the repeatable battery for the assessment of neuropsychological status. Psychiatry Research, 129(1), 45–53.

    Article  PubMed  Google Scholar 

  • Duvernoy, H. W. (1998). The human hippocampus: Functional anatomy, vascularization and series sections with MRI (2nd ed.). Berlin: Springer.

    Google Scholar 

  • Edwards, J., Jackson, H. J., & Pattison, P. E. (2002). Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clinical Psychology Review, 22(6), 789–832.

    Article  PubMed  Google Scholar 

  • Eichenbaum, H. (2004). Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron, 44(1), 109–120.

    Article  PubMed  CAS  Google Scholar 

  • Flaum, M., O’Leary, D. S., 2nd Swayze, V. W., Miller, D. D., Arndt, S., & Andreasen, N. C. (1995). Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders. Journal of Psychiatric Research, 29(4), 261–276.

    Article  PubMed  CAS  Google Scholar 

  • Fletcher, P. C., Frith, C. D., & Rugg, M. D. (1997). The functional neuroanatomy of episodic memory. Trends in Neurosciences, 20(5), 213–218.

    Article  PubMed  CAS  Google Scholar 

  • Frey, B. N., Andreazza, A. C., Nery, F. G., Martins, M. R., Quevedo, J., Soares, J. C., et al. (2007). The role of hippocampus in the pathophysiology of bipolar disorder. Behavioural Pharmacology, 18(5–6), 419–430.

    Article  PubMed  Google Scholar 

  • Gabrieli, J. D., Brewer, J. B., & Poldrack, R. A. (1998). Images of medial temporal lobe functions in human learning and memory. Neurobiology of Learning and Memory, 70(1–2), 275–283.

    Article  PubMed  CAS  Google Scholar 

  • Goldman, M. B., & Mitchell, C. P. (2004). What is the functional significance of hippocampal pathology in schizophrenia? Schizophrenia Bulletin, 30(2), 367–392.

    Article  PubMed  Google Scholar 

  • Hafner, H., Maurer, K., Loffler, W., an der Heiden, W., Hambrecht, M., & Schultze-Lutter, F. (2003). Modeling the early course of schizophrenia. Schizophrenia Bulletin, 29(2), 325–340.

    Article  PubMed  Google Scholar 

  • Harrison, P. J. (1999). The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain: A Journal of Neurology, 122(Pt 4), 593–624.

    Article  Google Scholar 

  • Harrison, P. J. (2004). The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications. Psychopharmacology, 174(1), 151–162.

    Article  PubMed  CAS  Google Scholar 

  • Harvey, P. D., & Penn, D. (2010). Social cognition: the key factor predicting social outcome in people with schizophrenia? Psychiatry (Edgmont (Pa.: Township)), 7(2), 41–44.

    Google Scholar 

  • Heckers, S. (2001). Neuroimaging studies of the hippocampus in schizophrenia. Hippocampus, 11(5), 520–528.

    Article  PubMed  CAS  Google Scholar 

  • Hill, S. K., Reilly, J. L., Harris, M. S., Rosen, C., Marvin, R. W., Deleon, O., et al. (2009). A comparison of neuropsychological dysfunction in first-episode psychosis patients with unipolar depression, bipolar disorder, and schizophrenia. Schizophrenia Research, 113(2–3), 167–175.

    Article  PubMed  Google Scholar 

  • Hoff, A. L., Riordan, H., O’Donnell, D., Stritzke, P., Neale, C., Boccio, A., et al. (1992). Anomalous lateral sulcus asymmetry and cognitive function in first-episode schizophrenia. Schizophrenia Bulletin, 18(2), 257–272.

    PubMed  CAS  Google Scholar 

  • Horan, W. P., Subotnik, K. L., Snyder, K. S., & Nuechterlein, K. H. (2006). Do recent-onset schizophrenia patients experience a “social network crisis”? Psychiatry, 69(2), 115–129.

    Article  PubMed  Google Scholar 

  • Joyal, C. C., Laakso, M. P., Tiihonen, J., Syvalahti, E., Vilkman, H., Laakso, A., et al. (2003). The amygdala and schizophrenia: a volumetric magnetic resonance imaging study in first-episode, neuroleptic-naive patients. Biological Psychiatry, 54(11), 1302–1304.

    Article  PubMed  Google Scholar 

  • Kasai, K., Shenton, M. E., Salisbury, D. F., Hirayasu, Y., Onitsuka, T., Spencer, M. H., et al. (2003). Progressive decrease of left heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Archives of General Psychiatry, 60(8), 766–775.

    Article  PubMed  Google Scholar 

  • Kaufman, A. S., & Lichtenberger, E. (2006). Assessing adolescent and adult intelligence (3rd ed.). Hoboken: Wiley.

    Google Scholar 

  • Kay, S. R., Fiszbein, A., & Opler, L. A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13(2), 261–276.

    PubMed  CAS  Google Scholar 

  • Keller, J., Shen, L., Gomez, R. G., Garrett, A., Solvason, H. B., Reiss, A., et al. (2008). Hippocampal and amygdalar volumes in psychotic and nonpsychotic unipolar depression. The American Journal of Psychiatry, 165(7), 872–880.

    Article  PubMed  Google Scholar 

  • Kempton, M. J., Geddes, J. R., Ettinger, U., Williams, S. C., & Grasby, P. M. (2008). Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder. Archives of General Psychiatry, 65(9), 1017–1032.

    Article  PubMed  Google Scholar 

  • Kensinger, E. A. (2009). Remembering the details: effects of emotion. Emotion Review, 1(2), 99–113.

    Article  PubMed  Google Scholar 

  • Ketter, T. A., Wang, P. W., Becker, O. V., Nowakowska, C., & Yang, Y. (2004). Psychotic bipolar disorders: dimensionally similar to or categorically different from schizophrenia? Journal of Psychiatric Research, 38(1), 47–61.

    Article  PubMed  Google Scholar 

  • Killgore, W. D., Rosso, I. M., Gruber, S. A., & Yurgelun-Todd, D. A. (2009). Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder. Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology, 22(1), 28–37.

    Article  Google Scholar 

  • Lake, C. R., & Hurwitz, N. (2006). Schizoaffective disorders are psychotic mood disorders; there are no schizoaffective disorders. Psychiatry Research, 143(2–3), 255–287.

    Article  PubMed  Google Scholar 

  • LeDoux, J. E. (2000). Emotion circuits in the brain. Annual Review of Neuroscience, 23, 155–184.

    Article  PubMed  CAS  Google Scholar 

  • Mathalon, D. H., Sullivan, E. V., Rawles, J. M., & Pfefferbaum, A. (1993). Correction for head size in brain-imaging measurements. Psychiatry Research, 50(2), 121–139.

    Article  PubMed  CAS  Google Scholar 

  • McDonald, C., Bullmore, E. T., Sham, P. C., Chitnis, X., Wickham, H., Bramon, E., et al. (2004). Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Archives of General Psychiatry, 61(10), 974–984.

    Article  PubMed  Google Scholar 

  • McDonald, C., Bullmore, E., Sham, P., Chitnis, X., Suckling, J., MacCabe, J., et al. (2005). Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: computational morphometry study. The British Journal of Psychiatry: The Journal of Mental Science, 186, 369–377.

    Article  Google Scholar 

  • McGurn, B., Starr, J. M., Topfer, J. A., Pattie, A., Whiteman, M. C., Lemmon, H. A., et al. (2004). Pronunciation of irregular words is preserved in dementia, validating premorbid IQ estimation. Neurology, 62(7), 1184–1186.

    PubMed  CAS  Google Scholar 

  • Moorhead, T. W., McKirdy, J., Sussmann, J. E., Hall, J., Lawrie, S. M., Johnstone, E. C., et al. (2007). Progressive gray matter loss in patients with bipolar disorder. Biological Psychiatry, 62(8), 894–900.

    Article  PubMed  Google Scholar 

  • Morgan, K. D., Dazzan, P., Orr, K. G., Hutchinson, G., Chitnis, X., Suckling, J., et al. (2007). Grey matter abnormalities in first-episode schizophrenia and affective psychosis. The British Journal of Psychiatry. Supplement, 51, s111–s116.

    Article  PubMed  Google Scholar 

  • Murray, R. M., Sham, P., Van Os, J., Zanelli, J., Cannon, M., & McDonald, C. (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research, 71(2–3), 405–416.

    Article  PubMed  Google Scholar 

  • Nakamura, M., Salisbury, D. F., Hirayasu, Y., Bouix, S., Pohl, K. M., Yoshida, T., et al. (2007). Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI study. Biological Psychiatry, 62(7), 773–783.

    Article  PubMed  Google Scholar 

  • Nelson, M. D., Saykin, A. J., Flashman, L. A., & Riordan, H. J. (1998). Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Archives of General Psychiatry, 55(5), 433–440.

    Article  PubMed  CAS  Google Scholar 

  • Ng, W. X., Lau, I. Y., Graham, S., & Sim, K. (2009). Neurobiological evidence for thalamic, hippocampal and related glutamatergic abnormalities in bipolar disorder: a review and synthesis. Neuroscience and Biobehavioral Reviews, 33(3), 336–354.

    Article  PubMed  CAS  Google Scholar 

  • Niu, L., Matsui, M., Zhou, S. Y., Hagino, H., Takahashi, T., Yoneyama, E., et al. (2004). Volume reduction of the amygdala in patients with schizophrenia: a magnetic resonance imaging study. Psychiatry Research, 132(1), 41–51.

    Article  PubMed  Google Scholar 

  • Pedraza, O., Bowers, D., & Gilmore, R. (2004). Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. Journal of the International Neuropsychological Society: JINS, 10(5), 664–678.

    Article  PubMed  Google Scholar 

  • Pegues, M. P., Rogers, L. J., Amend, D., Vinogradov, S., & Deicken, R. F. (2003). Anterior hippocampal volume reduction in male patients with schizophrenia. Schizophrenia Research, 60(2–3), 105–115.

    Article  PubMed  Google Scholar 

  • Phelps, E. A. (2004). Human emotion and memory: interactions of the amygdala and hippocampal complex. Current Opinion in Neurobiology, 14(2), 198–202.

    Article  PubMed  CAS  Google Scholar 

  • Ragland, J. D., Yoon, J., Minzenberg, M. J., & Carter, C. S. (2007). Neuroimaging of cognitive disability in schizophrenia: search for a pathophysiological mechanism. International Review of Psychiatry (Abingdon, England), 19(4), 417–427.

    Article  CAS  Google Scholar 

  • Rajarethinam, R., DeQuardo, J. R., Miedler, J., Arndt, S., Kirbat, R., Brunberg, J. A., et al. (2001). Hippocampus and amygdala in schizophrenia: assessment of the relationship of neuroanatomy to psychopathology. Psychiatry Research, 108(2), 79–87.

    Article  PubMed  CAS  Google Scholar 

  • Reichenberg, A., & Harvey, P. D. (2007). Neuropsychological impairments in schizophrenia: integration of performance-based and brain imaging findings. Psychological Bulletin, 133(5), 833–858.

    Article  PubMed  Google Scholar 

  • Rosso, I. M., Killgore, W. D., Cintron, C. M., Gruber, S. A., Tohen, M., & Yurgelun-Todd, D. A. (2007). Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter. Biological Psychiatry, 61(6), 743–749.

    Article  PubMed  Google Scholar 

  • Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001). A review of MRI findings in schizophrenia. Schizophrenia Research, 49(1–2), 1–52.

    Article  PubMed  CAS  Google Scholar 

  • Sigmundsson, T., Suckling, J., Maier, M., Williams, S., Bullmore, E., Greenwood, K., et al. (2001). Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. The American Journal of Psychiatry, 158(2), 234–243.

    Article  PubMed  CAS  Google Scholar 

  • Steen, R. G., Mull, C., McClure, R., Hamer, R. M., & Lieberman, J. A. (2006). Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. The British Journal of Psychiatry: The Journal of Mental Science, 188, 510–518.

    Article  Google Scholar 

  • Strakowski, S. M., DelBello, M. P., Sax, K. W., Zimmerman, M. E., Shear, P. K., Hawkins, J. M., et al. (1999). Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry, 56(3), 254–260.

    Article  PubMed  CAS  Google Scholar 

  • Strasser, H. C., Lilyestrom, J., Ashby, E. R., Honeycutt, N. A., Schretlen, D. J., Pulver, A. E., et al. (2005). Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study. Biological Psychiatry, 57(6), 633–639.

    Article  PubMed  Google Scholar 

  • Suzuki, M., Zhou, S. Y., Hagino, H., Niu, L., Takahashi, T., Kawasaki, Y., et al. (2005). Morphological brain changes associated with schneider’s first-rank symptoms in schizophrenia: a MRI study. Psychological Medicine, 35(4), 549–560.

    Article  PubMed  CAS  Google Scholar 

  • Thoma, R. J., Monnig, M., Hanlon, F. M., Miller, G. A., Petropoulos, H., Mayer, A. R., et al. (2009). Hippocampus volume and episodic memory in schizophrenia. Journal of the International Neuropsychological Society: JINS, 15(2), 182–195.

    Article  PubMed  Google Scholar 

  • Velakoulis, D., Pantelis, C., McGorry, P. D., Dudgeon, P., Brewer, W., Cook, M., et al. (1999). Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Archives of General Psychiatry, 56(2), 133–141.

    Article  PubMed  CAS  Google Scholar 

  • Velakoulis, D., Wood, S. J., Wong, M. T., McGorry, P. D., Yung, A., Phillips, L., et al. (2006). Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Archives of General Psychiatry, 63(2), 139–149.

    Article  PubMed  Google Scholar 

  • Vita, A., De Peri, L., Silenzi, C., & Dieci, M. (2006). Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies. Schizophrenia Research, 82(1), 75–88.

    Article  PubMed  CAS  Google Scholar 

  • Walker, J., Curtis, V., & Murray, R. M. (2002). Schizophrenia and bipolar disorder: similarities in pathogenic mechanisms but differences in neurodevelopment. International Clinical Psychopharmacology, 17(Suppl 3), S11–S19.

    PubMed  Google Scholar 

  • Wing, J. K., Babor, T., Brugha, T., Burke, J., Cooper, J. E., Giel, R., et al. (1990). SCAN. Schedules for clinical assessment in neuropsychiatry. Archives of General Psychiatry, 47(6), 589–593.

    Article  PubMed  CAS  Google Scholar 

  • Wood, S. J., Velakoulis, D., Smith, D. J., Bond, D., Stuart, G. W., McGorry, P. D., et al. (2001). A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia. Schizophrenia Research, 52(1–2), 37–46.

    Article  PubMed  CAS  Google Scholar 

  • World Health Organisation. (1992). The ICD-10 classification of mental and behavioural disorders. Geneva: World Health Organisation.

    Google Scholar 

  • Wright, I. C., Sharma, T., Ellison, Z. R., McGuire, P. K., Friston, K. J., Brammer, M. J., et al. (1999). Supra-regional brain systems and the neuropathology of schizophrenia. Cerebral Cortex (New York, N.Y.: 1991), 9(4), 366–378.

    Article  CAS  Google Scholar 

  • Yung, A. R., & McGorry, P. D. (1996). The initial prodrome in psychosis: descriptive and qualitative aspects. The Australian and New Zealand Journal of Psychiatry, 30(5), 587–599.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgement

Dr. John Foster MB, FRCR and his team in the MRI Unit, Belfast City Hospital, Belfast Health and Social Care Trust.

All subjects who were willing to participate in this research work.

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None.

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Funded by the Research and Development Office of the Northern Ireland Health and Personal Social Services.

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Authors and Affiliations

  1. Computational Neuroscience, ISRC, University of Ulster (Magee), Northland Road, Londonderry, BT48 7JL, UK

    David R. Watson

  2. School of Medicine, South East University, Nanjing, China

    Feng Bai

  3. Psychiatry, Queen’s University, Belfast, UK

    Suzanne L. Barrett, Aidan Turkington, Ciaran C. Mulholland & Stephen J. Cooper

  4. Psychology, University of Ulster, Londonderry, UK

    Teresa M. Rushe

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Correspondence to David R. Watson.

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Watson, D.R., Bai, F., Barrett, S.L. et al. Structural changes in the hippocampus and amygdala at first episode of psychosis. Brain Imaging and Behavior 6, 49–60 (2012). https://doi.org/10.1007/s11682-011-9141-4

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