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Characteristics of the Structural Connectivity in Patients with Brain Injury and Chronic Health Symptoms: A Pilot Study

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Abstract

Diffusion properties from diffusion tensor imaging (DTI) are exquisitely sensitive to white matter abnormalities incurred during traumatic brain injury (TBI), especially for those patients with chronic post-TBI symptoms such as headaches, dizziness, fatigue, etc. The evaluation of structural and functional connectivity using DTI has become a promising method for identifying subtle alterations in brain connectivity associated with TBI that are otherwise not visible with conventional imaging. This study assessed whether TBI patients with (n = 17) or without (n = 16) chronic symptoms (TBIcs/TBIncs) exhibit any changes in structural connectivity (SC) and mean fractional anisotropy (mFA) of intra- and inter-hemispheric connections when compared to a control group (CG) (n = 13). Reductions in SC and mFA were observed for TBIcs compared to CG, but not for TBIncs. More connections were found to have mFA reductions than SC reductions. On the whole, SC is dominated by ipsilateral connections for all the groups after the comparison of contralateral and ipsilateral connections. More contra-ipsi reductions of mFA were found for TBIcs than TBIncs compared to CG. These findings suggest that TBI patients with chronic symptoms not only demonstrate decreased global and regional mFA but also reduced structural network connectivity.

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Acknowledgements

We would like to thank Santa Clara Brain Injury Center and our Veterans for their support to the study.

Funding

This study was supported by War Related Illness and Injury Center (WRIISC) located at VA Palo Alto.

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Authors and Affiliations

  1. WRIISC-Women, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA, 94304, USA

    Xiaojian Kang & Maheen M. Adamson

  2. Rehabilitation Service, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA, 94304, USA

    Xiaojian Kang & Maheen M. Adamson

  3. Department of Radiology, Stanford University School of Medicine, VA Palo Alto Heath Care System, Palo Alto, CA, 94304, USA

    Byung C. Yoon

  4. Department of Psychology, VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA, 94304, USA

    Emily Grossner

  5. Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA, 94305, USA

    Maheen M. Adamson

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Kang, X., Yoon, B.C., Grossner, E. et al. Characteristics of the Structural Connectivity in Patients with Brain Injury and Chronic Health Symptoms: A Pilot Study. Neuroinform 22, 573–589 (2024). https://doi.org/10.1007/s12021-024-09681-7

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