Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
Skip to main content

Advertisement

Springer Nature Link
Log in

WebFPTI: A tool to predict the toxicity/pathogenicity of mineral fibres including asbestos

  • Software Article
  • Published:
Earth Science Informatics Aims and scope Submit manuscript

Abstract

The risk assessment for the human health of airborne mineral fibres, including asbestos minerals, is a complex task. WebFPTI is a browser-based software written in Python that allows users to calculate an index of toxicity and pathogenicity potential of mineral fibres based on their crystal-chemical-physical properties. WebFPTI can be a powerful tool for both academy and environmental/health institutions to classify the carcinogenicity potential of (respirable) mineral fibres, so that specific actions aimed at protecting workers and general public can be fostered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Data availability

The user can access the WebFPTI application via the URL: http://fibers-fpti.unimore.it. The application can be accessed using a Web browser. To get “Contributing users” account, submit your request to one of these email addresses: mauro.leoncini@unimore.it, alessandro.gualtieri@unimore.it, dario.digiuseppe@unimore.it.

References

  • Ballirano P, Cametti G (2015) Minerals in the human body. Crystal chemical and structural modifications of erionite fibers leached with simulated lung fluids. Am Mineral 100:1003–1012

    Article  Google Scholar 

  • Belluso E, Cavallo A, Halterman D (2017) Crystal habit of mineral fibres. In: Gualtieri AF (ed) Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity. European Mineralogical Union, London, pp 65–109

    Chapter  Google Scholar 

  • Berman D, Crump K (2008) A meta-analysis of asbestos-related cancer risk that addresses fiber size and mineral type. Cri Rev Toxicol 38:49–73

    Article  Google Scholar 

  • Carbone M, Emri S, Dogan AU, Steele I, Tuncer M, Pass HI, Baris Y (2007) A mesothelioma epidemic in Cappadocia: Scientific developments and unexpected social outcomes. Nat Rev Cancer 7:147–154

    Article  Google Scholar 

  • Churg A (1993) Asbestos lung burden and disease patterns in man. In: Guthrie GD, Mossmann BT (eds) Health Effects of Mineral Dust, Reviews in Mineralogy, Volume 28. Mineralogical Society of America, Chantilly, pp 409–426. https://doi.org/10.1515/9781501509711-016

  • Comba P, Gianfagna A, Paoletti L (2003) Pleural mesothelioma cases in Biancavilla are related to a new fluoro-edenite fibrous amphibole. Arch Environ Health 58:229–232

    Article  Google Scholar 

  • Deng ZJ, Liang ML, Tóth I, Monteiro MJ, Michin RF (2012) Molecular interaction of poly (acrylic acid) gold nanoparticles with human fibrinogen. ACS Nano 6:8962–8969

    Article  Google Scholar 

  • Di Giuseppe D, Harper M, Bailey M, Erskine B, Della Ventura G, Ardit M, Pasquali L, Tomaino G, Ray R, Mason H, Dyar MD, Hanuskova M, Giacobbe C, Zoboli A, Gualtieri AF (2019) Characterization and assessment of the potential toxicity/pathogenicity of fibrous glaucophane. Environ Res 178:108723

    Article  Google Scholar 

  • Donaldson K, Murphy FA, Duffin R, Poland CA (2010) Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Tox 7:5

    Article  Google Scholar 

  • Erskine BG, Bailey M (2018) Characterization of asbestiform glaucophane-winchite in the Franciscan Complex blueschist, northern Diablo Range, California. Toxicol Appl Pharm 361:3–13

    Article  Google Scholar 

  • Gualtieri AF (2018) Towards a quantitative model to predict the toxicity/pathogenicity potential of mineral fibers. Toxicol Appl Pharm 361:89–98

    Article  Google Scholar 

  • Gualtieri AF, Zoboli A, Filaferro M, Benassi M, Scarfì S, Mirata S, Avallone R, Vitale G, Bailey M, Harper M, Di Giuseppe D (2021) In vitro toxicity of fibrous glaucophane. Toxicology 454:152743

  • Gualtieri AF, Andreozzi GB, Tomatis M, Turci F (2019a) Iron from a geochemical viewpoint. Understanding toxicity/pathogenicity mechanisms in iron-bearing minerals with a special attention to mineral fibers. Free Radical Bio Med 133:21–37

    Article  Google Scholar 

  • Gualtieri AF, Lusvardi G, Zoboli A, Di Giuseppe D, Lassinantti Gualtieri M (2019b) Biodurability and release of metals during the dissolution of chrysotile, crocidolite and fibrous erionite. Environ Res 171:550–557

    Article  Google Scholar 

  • Gualtieri AF, Mossman BT, Roggli VL (2017) Towards a general model for predicting the toxicity and pathogenicity of mineral fibres. In: Gualtieri AF (ed) Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity. European Mineralogical Union, London, pp 501–532

    Chapter  Google Scholar 

  • Gualtieri AF, Pollastri S, Bursi Gandolfi N, Lassinantti Gualtieri M (2018) In vitro acellular dissolution of mineral fibres: A comparative study. Sci Rep 8:7071

    Article  Google Scholar 

  • Hamade AK, Long CM, Valberg PA (2015) Naturally Occurring Mineral Fibers. In: Harbison RD, Bourgeois MM, Johnson GT (eds) Hamilton & Hardy’s Industrial Toxicology. John Wiley & Sons, Bristol, pp 997–1024

    Google Scholar 

  • IARC (2012) Asbestos (chrysotile, amosite, crocidolite, tremolite, actinolite, and anthophyllite). IARC Monogr Eval Carcinog Risks Hum 100C:219–309

    Google Scholar 

  • IARC (2017) Some Nanomaterials and Some Fibres. IARC Monogr Eval Carcinog Risks Hum 111:215–240

    Google Scholar 

  • Lynch I, Dawson KA (2008) Protein-nanoparticle interactions. Nano Today 3:40–47

  • Nicholson WJ (1986) Airborne asbestos health assessment update. Report 600/8–84–003F, U.S. Environmental Protection Agency, Washington, DC. https://ntrl.ntis.gov/NTRL/dashboard/searchResults.xhtml?searchQuery=PB86242864&starDB=GRAHIST

  • Pollastri S, Gualtieri AF, Lassinantti Gualtieri M, Hanuskova M, Cavallo A, Gaudino G (2014) The zeta potential of mineral fibres. J Hazard Mater 276:469–479

    Article  Google Scholar 

  • Stanton MF, Layard M, Tegeris A, Miller E, May M, Morgan E, Smith A (1981) Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst 67:965–975

    Google Scholar 

Download references

Funding

This research was supported by the grant “Fondi di Ateneo per la Ricerca (FAR 2017)—Fiber potential toxicity Index (FPTI). A quantitative model to evaluate the toxicity and pathogenicity of mineral fibers, including asbestos” and later under the project “Fibres: A Multidisciplinary Mineralogical, Crystal-Chemical and Biological Project to Amend the Paradigm of Toxicity and Cancerogenicity of Mineral Fibres” (PRIN – Bando 2017—Prot. 20173X8WA4).

Author information

Authors and Affiliations

  1. Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy

    Alessandro F. Gualtieri, Alessandro Zoboli & Dario Di Giuseppe

  2. Department of Physics, Informatics and Mathematics, University of Modena and Reggio Emilia, Via G. Campi 213/b, 41125, Modena, Italy

    Mauro Leoncini & Lorenzo Rinaldi

Authors
  1. Alessandro F. Gualtieri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mauro Leoncini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lorenzo Rinaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alessandro Zoboli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dario Di Giuseppe
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

A.F.G. conceived the idea and wrote together with D.D.G. the manuscript with the contribution of all the co-authors. M.L. and L. R. made the web-based application. A.F.G, D.G.G. and A.Z. carried out the study concerning fibrous glaucophane.

Corresponding author

Correspondence to Dario Di Giuseppe.

Ethics declarations

Conflict of interest

Authors confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Additional information

Communicated by H. Babaie

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gualtieri, A.F., Leoncini, M., Rinaldi, L. et al. WebFPTI: A tool to predict the toxicity/pathogenicity of mineral fibres including asbestos. Earth Sci Inform 14, 2401–2409 (2021). https://doi.org/10.1007/s12145-021-00646-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12145-021-00646-x

Keywords

Search

Navigation