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Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy

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Abstract

Nanomedicine with high specificity has been a promising tool for cancer diagnosis and therapy. However, the successful application of nanoparticle-based superficial cancer therapy is severely hindered by restricted deep tumor tissue accumulation and penetration. Herein, a self-assembly nanomicelle dissolving microneedle (DMN) patch according to the “nano in micro” strategy was conducted to co-deliver a first-line chemotherapeutic agent paclitaxel (PTX), and a photosensitizer IR780 (PTX/IR780-NMs @DMNs) for chemo-photothermal synergetic melanoma therapy. Upon direct insertion into the tumor site, DMNs created a regular and multipoint three-dimensional drug depot to maximize the tumor accumulation. Accompanied by the DMN dissolution, the composition of the needle matrixes self-assembled into nanomicelles, which could efficiently penetrate deep tumor tissue. Upon laser irradiation, the nanomicelles could not only ablate tumor cells directly by photothermal conversion but also trigger PTX release to induce tumor cell apoptosis. In vivo results showed that compared with intravenous injection, IR780 delivered by PTX/IR780-NMs @DMNs was almost completely accumulated at the tumor site. The antitumor results revealed that the PTX/IR780-NMs @DMNs could effectively eliminate tumors with an 88% curable rate without any damage to normal tissues. This work provides a versatile and generalizable framework for designing self-assembly DMN-mediated combination therapy to fight against superficial cancer.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81803466), the Key Areas Research and Development Program of Guangdong Province (No. 2019B020204002), and the Natural Science Foundation of Guangdong Province (No. 2021A1515012525).

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Author notes

  1. Ying Sun and Minglong Chen contributed equally to this work.

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China

    Ying Sun, Minglong Chen & Xin Pan

  2. College of Pharmacy, Jinan University, Guangzhou, 510632, China

    Dan Yang, Guilan Quan & Chuanbin Wu

  3. Jieyang Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 522091, China

    Wanbing Qin

  4. Physical Sciences at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, China

    Minglong Chen

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  1. Ying Sun
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  2. Minglong Chen
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  3. Dan Yang
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  5. Guilan Quan
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Correspondence to Guilan Quan or Xin Pan.

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Sun, Y., Chen, M., Yang, D. et al. Self-assembly nanomicelle-microneedle patches with enhanced tumor penetration for superior chemo-photothermal therapy. Nano Res. 15, 2335–2346 (2022). https://doi.org/10.1007/s12274-021-3817-x

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  • DOI: https://doi.org/10.1007/s12274-021-3817-x

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