Abstract
In recent years, the prevalence of Age-Related Illnesses (ARL) has been increasing among older individuals, and early recognition and treatment will result in better living conditions. It is well known that Alzheimer's Disease (AD) is among the ARD, and severe cases may result in dementia as well. It is the purpose of this study to propose a technique for distinguishing normal/AD brain MRI slices with improved accuracy utilizing the T2-modality. This scheme consists following phases: (i) Brain MRI collection and preprocessing, (ii) Deep feature extraction with the chosen scheme, (iii) Handcrafted feature extraction, (iv) Whale Algorithm (WA) based feature reduction and serial integration, and (v) binary classification using five-fold cross-validation. A total of 2000 MRI slices (1000 normal and 1000 AD class) are examined during this task using images collected from Alzheimer’s Disease Neuroimaging Initiative (ADNI). This study confirms that the proposed scheme provides a classification accuracy of > 98% when applied with the K-Nearest Classifier.
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17 February 2024
A Correction to this paper has been published: https://doi.org/10.1007/s12652-023-04749-9
References
Abdel-Basset M, Manogaran G, El-Shahat D, Mirjalili S (2018) Integrating the whale algorithm with tabu search for quadratic assignment problem: a new approach for locating hospital departments. Appl Soft Comput 73:530–546
Acharya UR, Fernandes SL, WeiKoh JE, Ciaccio EJ et al (2019) Automated detection of Alzheimer’s disease using brain MRI images–a study with various feature extraction techniques. J Med Syst 43(9):1–14
Aljarah I, Faris H, Mirjalili S (2018) Optimizing connection weights in neural networks using the whale optimization algorithm. Soft Comput 22(1):1–15
Alves GS, Kumar S, Sudo FK (2022) The interplay between long-term psychiatric disorders and age-related brain changes. Front Psychiatry. https://doi.org/10.3389/fpsyt.2022.898023
Balasubramaniam S, Satheesh Kumar K, Kavitha V, Prasanth A, Sivakumar TA (2022) Feature selection and dwarf mongoose optimization enabled deep learning for heart disease detection. Comput Intell Neurosci. https://doi.org/10.1155/2022/2819378
Beheshti I, Demirel H, Matsuda H (2017) Classification of Alzheimer’s disease and prediction of mild cognitive impairment-to-Alzheimer’s conversion from structural magnetic resource imaging using feature ranking and a genetic algorithm. Comput Biol Med 83:109–119
Braskie MN, Toga AW, Thompson PM (2013) Recent advances in imaging alzheimer’s disease. J Alzheimers Dis 33(1):S313–S327
Chui KT, Gupta BB, Alhalabi W, Alzahrani FS (2022) An MRI scans-based Alzheimer’s disease detection via convolutional neural network and transfer learning. Diagnostics 12(7):1531
Dhakhinamoorthy C, Mani SK, Mathivanan SK, Mohan S, Jayagopal P, Mallik S, Qin H (2023) Hybrid whale and gray wolf deep learning optimization algorithm for prediction of Alzheimer’s disease. Mathematics 11(5):1136
Dimitriadis SI, Liparas D, Tsolaki MN (2018) Random Forest feature selection, fusion and ensemble strategy: Combining multiple morphological MRI measures to discriminate among healhy elderly, MCI, cMCI and alzheimer’s disease patients: From the alzheimer’s disease neuroimaging initiative (ADNI) database. J Neurosci Methods 302:14–23
Ghazal TM, Abbas S, Munir SA, Khan M, Ahmad M, Issa G, Binish Zahra S, Adnan Khan M, Kamrul Hasan M (2022) Alzheimer disease detection empowered with transfer learning. Comput Mater Contin 70(3):5005–5019
Gudigar A, Raghavendra U, Devasia T, Nayak K, Danish SM et al (2019) Global weighted LBP based entropy features for the assessment of pulmonary hypertension. Pattern Recognit Lett 125:35–41
Haaksma ML, Vilela LR, Marengoni A, Calderón-Larrañaga A, Leoutsakos JS et al (2017) Comorbidity and progression of late onset Alzheimer’s disease: a systematic review. PLoS ONE 12(5):e0177044
Hu F, Zhou M, Li M, Bian K (2022) Joint feature selection of power load in time domain and frequency domain based on whale optimization algorithm. Int Trans Electr Energy Syst. https://doi.org/10.1155/2022/4139379
Hussien AG, Hassanien AE, Houssein EH, Bhattacharyya S, Amin M (2019) S-shaped binary whale optimization algorithm for feature selection. Recent trends in signal and image processing. Springer, Singapore, pp 79–87
Islam J, Zhang Y (2017) A novel deep learning based multi-class classification method for Alzheimer’s disease detection using brain MRI data. In: Brain informatics: international conference, BI 2017, Beijing, China, November 16–18, 2017, Proceedings. Springer International Publishing, pp 213–222
Jayachitra S, Prasanth A (2021) Multi-feature analysis for automated brain stroke classification using weighted Gaussian naïve Bayes classifier. J Circuits Syst Comput 30(10):2150178
Kadry S, Rajinikanth V, González Crespo R, Verdú E (2022) Automated detection of age-related macular degeneration using a pre-trained deep-learning scheme. J Supercomput 78(5):7321–7340
Khan MA, Rajinikanth V, Satapathy SC, Taniar D, Mohanty JR et al (2021) VGG19 network assisted joint segmentation and classification of lung nodules in CT images. Diagnostics 11(12):2208
Lu B, Li HX, Chang ZK, Li L, Chen NX, Zhu ZC et al (2022) A practical Alzheimer’s disease classifier via brain imaging-based deep learning on 85,721 samples. J Big Data 9(1):1–22
Mafarja M, Mirjalili S (2018) Whale optimization approaches for wrapper feature selection. Appl Soft Comput 62:441–453
Malik GA, Robertson NP (2017) Treatments in Alzheimer’s disease. J Neurol 264(2):416–418
Mason LM, Clarke AR, Barry RJ (2022) Age-related changes in the EEG in an eyes-open condition: II. Subtypes of AD/HD. Int J Psychophysiol 174:83–91
Mirjalili S, Lewis A (2016) The whale optimization algorithm. Adv Eng Softw 95:51–67
Mirjalili S, Mirjalili SM, Saremi S, Mirjalili S (2020) Whale optimization algorithm: theory, literature review, and application in designing photonic crystal filters. Nature-inspired optimizers. Springer, Cham, pp 219–238
Murugesan S, Bhuvaneswaran RS, Nehemiah HK, Sankari SK, Jane YN (2021) Feature selection and classification of clinical datasets using bioinspired algorithms and super learner. Comput Math Methods Med. https://doi.org/10.1155/2021/6662420
Odusami M, Maskeliūnas R, Damaševičius R (2022) An intelligent system for early recognition of Alzheimer’s disease using neuroimaging. Sensors 22(3):740
Oh SL, Jahmunah V, Arunkumar N, Abdulhay EW, Gururajan R et al (2021) A novel automated autism spectrum disorder detection system. Complex Intell Syst 7(5):2399–2413
Parmar H, Nutter B, Long L, Antani S, Mitra S (2020) Spatiotemporal feature extraction and classification of Alzheimer’s disease using deep learning 3D-CNN for fMRI data. J Med Imaging 7:056001
Petersen RC, Aisen PS, Beckett LA, Donohue MC, Gamst AC et al (2010) Alzheimer’s disease neuroimaging initiative (ADNI): clinical characterization. Neurology 74(3):201–209
Puente-Castro A, Fernandez-Blanco E, Pazos A, Munteanu CR (2020) Automatic assessment of Alzheimer’s disease diagnosis based on deep learning techniques. Comput Biol Med 120:103764
Rajinikanth V, Kadry S (2021) Development of a framework for preserving the disease-evidence-information to support efficient disease diagnosis. Int J Data Warehous Min (IJDWM) 17(2):63–84
Rajinikanth V, Aslam SM, Kadry S (2021) Deep learning framework to detect ischemic stroke lesion in brain MRI slices of flair/DW/T1 modalities. Symmetry 13(11):2080
Rajinikanth V, Kadry S, Taniar D, Kamalanand K, Elaziz MA et al (2022) Detecting epilepsy in EEG signals using synchro-extracting-transform (SET) supported classification technique. J Ambient Intell Human Comput. https://doi.org/10.1007/s12652-021-03676-x
Rajinikanth V, Kadry S, Moreno-Ger P (2023) ResNet18 supported inspection of tuberculosis in chest radiographs with integrated deep, LBP, and DWT features. Int J Interact Multimedia Artif Intell 8(Regular Issue, 2):38–46. https://doi.org/10.9781/ijimai.2023.05.004
Ramzan F, Khan MUG, Rehmat A, Iqbal S, Saba T et al (2019) A deep learning approach for automated diagnosis and multi-class classification of Alzheimer’s disease stages using resting-state fmri and residual neural networks. J Med Syst 44:37
Roy PK, Singh A (2023) COVID-19 disease prediction using weighted ensemble transfer learning. Int J Interact Multimedia Artif Intell 8(1):13–22. https://doi.org/10.9781/ijimai.2023.02.006. (Special issue on AI-driven algorithms and applications in the dynamic and evolving environments)
Savaş S (2022) Detecting the stages of Alzheimer’s disease with pre-trained deep learning architectures. Arab J Sci Eng 47(2):2201–2218
Sekar J, Aruchamy P, Sulaima Lebbe Abdul H, Mohammed AS, Khamuruddeen S (2022) An efficient clinical support system for heart disease prediction using TANFIS classifier. Comput Intell 38(2):610–640
Sharma R, Goel T, Tanveer M, Murugan R (2022) FDN-ADNet: fuzzy LS-TWSVM based deep learning network for prognosis of the Alzheimer’s disease using the sagittal plane of MRI scans. Appl Soft Comput 115:108099
Singh V, Jain D (2023) A hybrid parallel classification model for the diagnosis of chronic kidney disease. Int J Interact Multimedia Artif Intell 8(Regular Issue, 2):14–28. https://doi.org/10.9781/ijimai.2021.10.008
Smith LC, Turcotte DL, Isacks BL (1998) Stream flow characterization and feature detection using a discrete wavelet transform. Hydrol Process 12(2):233–249
Sree V, Mapes J, Dua S, Lih OS, Koh JE et al (2021) A novel machine learning framework for automated detection of arrhythmias in ECG segments. J Ambient Intell Humaniz Comput 12(11):10145–10162
Sridhar C, Lih OS, Jahmunah V, Koh JE, Ciaccio E et al (2021) Accurate detection of myocardial infarction using nonlinear features with ECG signals. J Ambient Intell Humaniz Comput 12(3):3227–3244
Stonnington CM, Chu C, Klöppel S, Jack CR, Ashburner J et al (2010) Predicting clinical scores from magnetic resonance scans in Alzheimer’s disease. Neuroimage 5(4):1405–1413
Striegl J, Gotthardt M, Loitsch C, Weber G (2022) Investigating the usability of voice assistant-based CBT for age-related depression. International conference on computers helping people with special needs. Springer, Cham, pp 432–441
Vijayakumar K, Rajinikanth V, Kirubakaran MK (2022) Automatic detection of breast cancer in ultrasound images using Mayfly algorithm optimized handcrafted features. J X-Ray Sci Technol 30:751–766
Wang T, Qiu RG, Yu M (2018) Predictive modeling of the progression of Alzheimer’s disease with recurrent neural networks. Sci Rep 8:9161
Yushkevich PA, Piven J, Hazlett HC, Smith RG, Ho S et al (2006) User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31(3):1116–1128
Zhang J, Liu M, An L, Gao Y, Shen D (2017) Alzheimer’s disease diagnosis using landmark-based features from longitudinal structural MR images. IEEE J Biomed Health Inform 21(6):1607–1616
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Kadry, S., Jessy, V.E., Rajinikanth, V. et al. Automatic classification of normal/AD brain MRI slices using whale-algorithm optimized hybrid image features. J Ambient Intell Human Comput 14, 14237–14248 (2023). https://doi.org/10.1007/s12652-023-04662-1
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DOI: https://doi.org/10.1007/s12652-023-04662-1