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RETRACTED ARTICLE: Prognostic and clinicopathological significance of survivin expression in bladder cancer patients: a meta-analysis

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Survivin has been widely reported to play a role in diagnosis and prognosis of bladder cancer patients. However, published data on this subject are heterogeneous. Here, we conducted a meta-analysis to obtain a complete evaluation of the association between survivin and recurrence-free survival (RFS), disease-specific survival (DSS), overall survival (OS), and odds ratio (OR) in bladder cancer patients. Published studies on this subject were selected for further assessment by online articles in PubMed, MEDLINE, EMBASE, and OVID databases. Pooled hazard ratios (HR) with 95 % confidence interval (95 % CI) were estimated. Funnel plots were used to evaluate the publication bias. As well, heterogeneity and sensitivity were analyzed. In this meta-analysis, we included 13 studies with the total number of 1,963 patients. Positive survivin expression in bladder cancer was associated with a poor RFS (HR, 1.831; 95 % CI, 1.344–2.49), DSS (HR, 1.721; 95 % CI, 1.477–2.004), or OS (HR, 1.753; 95 % CI, 1.092–2.816) in patients. In addition, a significant association between expression of survivin and age (OR, 0.641; 95 % CI, 0.416–0.987) as well as stage (OR, 0.37; 95 % CI, 0.190–0.750) was revealed. Heterogeneity was observed among the included studies with RFS (x 2 = 29.58, p = 0.009, I 2 = 52.7 %), OS (x 2 = 15.67, p = 0.008, I 2 = 68.1 %), and stage (x 2 = 11.97, p = 0.035, I 2 = 58.2 %). There was no publication bias according to Begg’s and Egger’s tests except for studies with gender. Furthermore, sensitivity analysis obtained the source of heterogeneity and confirmed opposite results of some studies. This study suggests that expression of survivin indicates poor prognosis in older patients and muscle invasive or advanced stage in bladder cancer. Survivin expression could be used in identifying a subgroup of patients with potential to benefit from a targeted therapy against survivin.

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Acknowledgments

This study was supported by China Scholarship Council. We were also very thankful to the support of Sun lab staff for their valuable advice.

Conflict of interest

The authors state that there are no conflicts of interest to disclose.

Author information

Authors and Affiliations

  1. Department of Surgery, University of Toronto, Toronto, ON, Canada

    Shunzeng Lv, Ekaterina Turlova & Hong-Shuo Sun

  2. Department of Medicine, Shanghai Jiaotong University, Shanghai, China

    Shigang Zhao

  3. Department of Medicine, Shandong University, Jinan Shandong, China

    Huihui Kang & Mingzhi Han

Authors
  1. Shunzeng Lv
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  2. Ekaterina Turlova
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  3. Shigang Zhao
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  4. Huihui Kang
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  5. Mingzhi Han
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  6. Hong-Shuo Sun
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Corresponding author

Correspondence to Hong-Shuo Sun.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Lv, S., Turlova, E., Zhao, S. et al. RETRACTED ARTICLE: Prognostic and clinicopathological significance of survivin expression in bladder cancer patients: a meta-analysis. Tumor Biol. 35, 1565–1574 (2014). https://doi.org/10.1007/s13277-013-1216-y

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  • DOI: https://doi.org/10.1007/s13277-013-1216-y

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