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RETRACTED ARTICLE: CYP1A2 rs762551 polymorphism contributes to risk of lung cancer: A meta-analysis

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Previous studies proposed that CYP1A2 rs762551 polymorphism might be associated with risk of lung cancer by influencing the function of CYP1A2. However, previous studies on the association between CYP1A2 rs762551 polymorphism and risk of lung cancer reported inconsistent findings. We performed a meta-analysis of the published case–control studies to assess the association between CYP1A2 rs762551 polymorphism and risk of lung cancer. PubMed and Embase were searched to identify relevant studies on the association between CYP1A2 rs762551 polymorphism and risk of lung cancer, and seven studies with a total of 3,320 subjects were finally included into the meta-analysis. The pooled odds ratio (OR) and 95 % confidence interval (95%CI) was calculated to evaluate the association. Meta-analysis of total studies showed that CYP1A2 rs762551 polymorphism contributed to risk of lung cancer under all four genetic models (C versus A: OR = 1.26, 95%CI 1.13 to 1.40, P < 0.001; CC versus AA: OR = 1.61, 95%CI 1.28 to 2.04, P < 0.001; CC versus AA/AC: OR = 1.52, 95%CI 1.11 to 2.09, P = 0.009; CC/AC versus AA: OR = 1.28, 95%CI 1.10 to 1.48, P = 0.001). Subgroup analysis based on ethnicity further suggested that CYP1A2 rs762551 polymorphism was associated with risk of lung cancer in Caucasians. These results from the meta-analysis suggest that CYP1A2 rs762551 polymorphism contributes to risk of lung cancer.

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Authors and Affiliations

  1. Department of General Thoracic Surgery, Daping Hospital and Institute of Surgery Research, the Third Millitary Medical University, 10# Changjiang Zhilu Road, 400042, Yuzhong Distric, Chongqing, People’s Republic of China

    Zheng Ma, Wei Guo, Taiqian Gong, Hui-Jun Niu, Ru-Wen Wang & Yao-Guang Jiang

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  1. Zheng Ma
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  2. Wei Guo
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  3. Taiqian Gong
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Correspondence to Zheng Ma.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Ma, Z., Guo, W., Gong, T. et al. RETRACTED ARTICLE: CYP1A2 rs762551 polymorphism contributes to risk of lung cancer: A meta-analysis. Tumor Biol. 35, 2253–2257 (2014). https://doi.org/10.1007/s13277-013-1298-6

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  • DOI: https://doi.org/10.1007/s13277-013-1298-6

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