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RETRACTED ARTICLE: Efficient inhibition of growth of metastatic cancer cells after resection of primary colorectal cancer by soluble Flt-1

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

Removal of primary tumors often leads to increases in growth of metastatic tumor cells. Thus, development of an efficient treatment to inhibit the growth of metastatic tumor cells after resection of primary tumors appears to be critical for cancer therapy. Here, we reported that administration of a Chinese medicine Shiquandabutao (SQDBT) after removal of the primary cancer significantly inhibited the growth of metastatic cancer cells in mouse liver. Further analyses showed that the effect of SQDBT resulted from one of its main component, Siwutang (SWT), rather than from another main component, Sijunzitang (SJZT). Moreover, we found that the soluble Flt-1 from SWT neutralized the increased placental growth factor (PLGF) secreted by the metastatic cancer cells after primary cancer resection and subsequently inhibited the cancer neovascularization to suppress the metastatic cancer growth. Thus, our study reveals an essential role of SQDBT in inhibiting the growth of metastatic cancer after removal of primary cancer and further highlights PLGF as a potential target for metastatic cancer treatment.

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Acknowledgments

This work was financially supported by National Nature Science Foundation of China (no. 81273733).

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Authors and Affiliations

  1. Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Road, Putuo District, Shanghai, 200062, China

    Yong Zhang, Ao Li, Weizhen Peng, Jue Sun, Fangming Xu & Jianhua Xu

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  1. Yong Zhang
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  2. Ao Li
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  3. Weizhen Peng
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  4. Jue Sun
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  5. Fangming Xu
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  6. Jianhua Xu
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Corresponding author

Correspondence to Jianhua Xu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Zhang, Y., Li, A., Peng, W. et al. RETRACTED ARTICLE: Efficient inhibition of growth of metastatic cancer cells after resection of primary colorectal cancer by soluble Flt-1. Tumor Biol. 36, 7399–7407 (2015). https://doi.org/10.1007/s13277-015-3434-y

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  • DOI: https://doi.org/10.1007/s13277-015-3434-y

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