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The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis

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Abstract

Adenomyosis is a benign disease with a malignant behavior, bothering a lot of women at reproductive age who suffer from increased menstruation, prolonged menstruation, progressive dysmenorrhea, and infertility. At present, there is no effective treatment for adenomyosis. It seriously affects the life quality of these patients. However, the pathogenesis of adenomyosis is not yet clear. Recently, uterus junctional zone, defined as the inner 1/3 of myometrium between endometrium and myometrium, has gained broad attention. As is reported, the structure and function disorder of uterus junctional zone may play an important part in the occurrence and development of adenomyosis. In this issue, the present study generally reviews the role of uterine junction zone and the related mechanisms involved in adenomyosis, such as the local micro-damage, the formation of inflammatory and hypoxic microenvironment, changes of cytokines, and abnormalities of miRNA as well as signal pathways. It will provide new insights and potential therapeutic target strategies for clinical strategies in the management of adenomyosis.

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Funding

This work was supported by the Presidential Foundation of Nanfang Hospital, China (Grant 2018A002).

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  1. Tingting Xie and Xiya Xu contributed equally to this work.

Authors and Affiliations

  1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China

    Tingting Xie, Xiya Xu & Yi Yang

  2. Southern Medical University, Guangzhou, China

    Cangui Wu & Xiaohan Liu

  3. State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Ave., Guangzhou, 510515, China

    Lili Zhou

  4. Center for Reproductive Medicine, Dongguan Maternal and Child Health Care Hospital, Southern Medical University, No.99 Zhenxing Road, Dongguan, 523000, China

    Yali Song

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  1. Tingting Xie
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Xie, T., Xu, X., Yang, Y. et al. The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis. Reprod. Sci. 29, 2719–2730 (2022). https://doi.org/10.1007/s43032-021-00684-2

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