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A poly(acrylic acid)-modified copper-organic framework for electrochemical determination of vancomycin

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Abstract

A copper(II) benzene-1,3,5-tricarboxylate (BTC) metal-organic framework (MOF) was modified with poly(acrylic acid) (PAA) and then used in an electrochemical sensor for vancomycin. The MOF, synthesized via a single-pot method, has enhanced solubility and dispersibility in water as compared to HKUST-1 but without compromising its crystallinity and porosity. The MOF was placed on a glassy carbon electrode (GCE) where it shows enhanced electrocatalytic properties. This is assumed to be due to the presence of the poly(acrylic acid) that forms a network between various HKUST-1 crystals through dimer formation between the carboxy groups of BTC and PAA. This also led to better dispersion of the MOF and to improved interaction between MOF and vancomycin. The structural, spectral and electrochemical properties of the MOFs and their vancomycin complexes was characterized. The modified GCE is shown to be a viable tool for electrochemical determination (best at a working potential of 784 mV vs. Ag/AgCl) of the antibiotic vancomycin in spiked urine and serum samples. Response is linear in the 1–500 nM vancomycin concentration range, and the detection limit is 1 nM, with a relative standard deviation of ±4.3%.

Schematic representation of a method for determination of vancomycin. Poly(acrylic acid) modified HKUST-1 (P-HKUST-1) forms a complex with vancomycin [Van-P-HKUST-1] which is coated over glassy carbon electrode (GCE). The decrease in peak current is recorded as response to vancomycin via cyclic voltammetry.

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Acknowledgements

The National Research Foundation of South Africa (NRF-SA) for funding (Grant No.103728 and 112079).

The authors would like to thank the College of Health Sciences, University of KwaZulu-Natal (UKZN), Nanotechnology platform-UKZN.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Health Sciences, University of KwaZulu Natal, Durban, 4000, South Africa

    Atal A. S. Gill, Sima Singh, Nikhil Agrawal, Zondi Nate, Tirivashe E. Chiwunze, Neeta Bachheti Thapliyal, Ruchika Chauhan & Rajshekhar Karpoormath

  2. Department of Applied Science, Women Institute of Technology, Suddhowala, Dehradun, Uttarakhand, 248007, India

    Neeta Bachheti Thapliyal

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  1. Atal A. S. Gill
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Correspondence to Rajshekhar Karpoormath.

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Gill, A.A.S., Singh, S., Agrawal, N. et al. A poly(acrylic acid)-modified copper-organic framework for electrochemical determination of vancomycin. Microchim Acta 187, 79 (2020). https://doi.org/10.1007/s00604-019-4015-3

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