Abstract
Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigenetic network that regulates autophagy. The identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3), microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and dimethylated H3K9 (H3K9me2)) associated with the autophagic process offers an attractive conceptual framework to understand the short-term transcriptional response and potential long-term responses to autophagy.
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Acknowledgements
J.F. is supported by a fellowship from the Karolinska Institute Foundation. Work in the author laboratory was supported by a US National Institute of Health (NIH) grant GM53396 (to D.J.K.), the Swedish Cancer Society, the Swedish Childhood Cancer Foundation and the Swedish Research Council (to B.J.).
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Füllgrabe, J., Klionsky, D. & Joseph, B. The return of the nucleus: transcriptional and epigenetic control of autophagy. Nat Rev Mol Cell Biol 15, 65â74 (2014). https://doi.org/10.1038/nrm3716
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DOI: https://doi.org/10.1038/nrm3716
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