Abstract
BACKGROUND: Body weight loss occurring after a hypoenergetic diet or a gastroplasty could be followed by an increase in blood concentration of potentially toxic pollutants that can interfere with the hormonal system (endocrine disrupters).
DESIGN: Thirty obese individuals recruited for gastroplasty were compared before and after treatment with 45 normal-weight people.
MEASUREMENTS: Blood samples were analyzed for DDT, DDE, HCB and PCBs no. 28, 52, 101, 118, 138, 153 and 180, by gas chromatographyâmass spectrometry.
RESULTS: The results indicate clearly that body weight loss occurring after gastroplasty increases plasma concentration of lipophilic pollutants.
CONCLUSION: Gastroplasty increases plasma concentration of organochlorine pesticides and PCBs, which could be a risk factor of endocrine disruption. Future longitudinal research will have to determine if the advantages of body weight loss are reduced by this potentially harmful effect.
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Charlier, C., Desaive, C. & Plomteux, G. Human exposure to endocrine disrupters: consequences of gastroplasty on plasma concentration of toxic pollutants. Int J Obes 26, 1465â1468 (2002). https://doi.org/10.1038/sj.ijo.0802144
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DOI: https://doi.org/10.1038/sj.ijo.0802144
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