Issue 57, 2015
From the journal:

Chemical Communications

Design of tumor-homing and pH-responsive polypeptide–doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects†

Jin Hu,a   Lining Xie,a   Wenguo Zhao,a   Mengmeng Sun,a   Xinyu Liua  and  Weiping Gao*a  

* Corresponding authors

a Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China
E-mail: gaoweiping@tsinghua.edu.cn

Abstract

Tumor-homing and pH-responsive polypeptide–drug nanoparticles for targeted cancer therapy are precisely designed by site-specific drug conjugation to a bioactive and well-defined elastin-like polypeptide through an acid-labile linker. In a murine cancer model, these nanoparticles show significantly better anti-tumor efficacy and less systemic toxicity than not only free drugs, but also polypeptide–drug nanoparticles without the tumor-homing function.

Graphical abstract: Design of tumor-homing and pH-responsive polypeptide–doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

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Article information

DOI
https://doi.org/10.1039/C5CC04035C
Article type
Communication
Submitted
15 May 2015
Accepted
10 Jun 2015
First published
11 Jun 2015

Chem. Commun., 2015,51, 11405-11408

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Design of tumor-homing and pH-responsive polypeptide–doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects

J. Hu, L. Xie, W. Zhao, M. Sun, X. Liu and W. Gao, Chem. Commun., 2015, 51, 11405 DOI: 10.1039/C5CC04035C

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