Issue 39, 2007
From the journal:

Chemical Communications

Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis†

Andrew M. Bailey,b   Russell J. Cox,*a   Kate Harley,a   Colin M. Lazarus,b   Thomas J. Simpson*a  and  Elizabeth Skellama  

* Corresponding authors

a School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: tom.simpson@bristol.ac.uk, r.j.cox@bristol.ac.uk
Fax: +44 117 9298611
Tel: +44 117 9287656

b School of Biological Sciences, University of Bristol, Woodland Road, Bristol, UK

Abstract

Isolation and sequencing of a PKS gene isolated from xenovulene-producing cultures of Acremonium strictum indicated the presence of NT-, KS-, AT-, PT-, C-MeT- and R-domains; heterologous expression in Aspergillus oryzae resulted in the production of 3-methylorcinaldehyde, demonstrating the role of the terminal reductase domain in product release.

Graphical abstract: Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

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Article information

DOI
https://doi.org/10.1039/B708614H
Article type
Communication
Submitted
06 Jun 2007
Accepted
28 Jun 2007
First published
25 Jul 2007

Chem. Commun., 2007, 4053-4055

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Characterisation of 3-methylorcinaldehyde synthase (MOS) in Acremonium strictum: first observation of a reductive release mechanism during polyketide biosynthesis

A. M. Bailey, R. J. Cox, K. Harley, C. M. Lazarus, T. J. Simpson and E. Skellam, Chem. Commun., 2007, 4053 DOI: 10.1039/B708614H

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