Issue 14, 2011
From the journal:

Soft Matter

PNIPAM microgels for biomedical applications: from dispersed particles to 3D assemblies

Ying Guana  and  Yongjun Zhang*a  

* Corresponding authors

a Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, China
E-mail: yongjunzhang@nankai.edu.cn
Fax: 86-22-23503510
Tel: 86-22-23501657

Abstract

Poly(N-isopropylacrylamide) (PNIPAM) microgel is perhaps the most well-known intelligent soft nanomaterial. Combining the strengths of hydrogel and nanoparticles, with unique stimuli-responsivity, PNIPAM microgels have found numerous biomedical applications, such as drug delivery, biosensing, and so on. Usually they were used as dispersed particles, however, they can also be used as building blocks to fabricate 2D films and 3D aggregates. These nanostructured assemblies exhibit new properties which the dispersed particles do not have, and new biomedical applications have been found for these assemblies. In this paper, the biomedical applications of PNIPAM microgels in the form of dispersed particles, 2D films and 3D aggregates were reviewed and some recent progress in this area was highlighted.

Graphical abstract: PNIPAM microgels for biomedical applications: from dispersed particles to 3D assemblies

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Article information

DOI
https://doi.org/10.1039/C0SM01541E
Article type
Review Article
Submitted
24 Dec 2010
Accepted
28 Mar 2011
First published
05 May 2011

Soft Matter, 2011,7, 6375-6384

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PNIPAM microgels for biomedical applications: from dispersed particles to 3D assemblies

Y. Guan and Y. Zhang, Soft Matter, 2011, 7, 6375 DOI: 10.1039/C0SM01541E

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