In this paper, the LSTM model in deep learning is applied to regression analysis, and the LSTM model is used to solve the problems of nonlinearity and data interdependence in regression analysis, so as to improve the traditional regression analysis model. Through the actual modeling application experiment, on the one hand, the prediction accuracy of different model parameters is compared and analyzed, on the other hand, the effectiveness and practicability of LSTM model in multiple regression analysis and prediction are confirmed.