A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence
Abstract
We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.
Footnotes
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↵3 Corresponding author.
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E-MAIL webb{at}cse.psu.edu; FAX (814) 865-3176.
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- Received May 18, 1998.
- Accepted July 21, 1998.
- Cold Spring Harbor Laboratory Press