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Volume 12 Supplement 7

UT-ORNL-KBRIN Bioinformatics Summit 2011

  • Meeting abstract
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Identification of alcohol preference relevant genes in QTL on mouse chromosome 2

BMC Bioinformatics volume 12, Article number: A2 (2011) Cite this article

Background

Previously, a quantitative trait loci (QTL) for alcohol preference on chromosome 2 in a C57BL/6IBG (B6) background has been identified. The overlap of two of interval specific congenic recombinant strains (ISCRS) strains reduced the QTL interval into a 3.4 mbp region.

Results

By using the keyword alcohol, we identified a total of 39 genetic elements in the region between markers D2Mit56 and D2Mit10. Among these genetic elements, we found seven with potential function in alcohol preference (Table 1). We then examined the SNPs, insertions and deletions, and gene expression levels of those seven genes.

Table 1 Candidate genes for alcohol preference on Chr 2.
Full size table

Conclusions

Our current data suggest that the Atf2 and Titin genes are potentially the most alcohol relevant genes. However, further experiments and examination are still needed to confirm their candidacy. Several other candidate genes are also in the process of being identified.

Acknowledgments

Support for this research is partially from the NIAAA (1R01 AA016342). NIH, the Veterans Administration Medical Center, and DNA Discovery Core, University of Tennessee, Memphis, TN.

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Authors and Affiliations

  1. Department of Orthopedic Surgery - Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Lishi Wang, Yan Jiao, Griffin Gibson, Xiaoyun Liu, Yue Huang & Weikuan Gu

  2. Department of Pharmacology, University of Colorado Denver, Aurora, CO, 80045-0508, USA

    Beth Bennett

  3. Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA

    Kristin Hamre & Robert Williams

Authors
  1. Lishi Wang
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  2. Yan Jiao
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  3. Griffin Gibson
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  4. Xiaoyun Liu
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  5. Yue Huang
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  6. Beth Bennett
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  7. Kristin Hamre
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  8. Robert Williams
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  9. Weikuan Gu
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Corresponding author

Correspondence to Weikuan Gu.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, L., Jiao, Y., Gibson, G. et al. Identification of alcohol preference relevant genes in QTL on mouse chromosome 2. BMC Bioinformatics 12 (Suppl 7), A2 (2011). https://doi.org/10.1186/1471-2105-12-S7-A2

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  • DOI: https://doi.org/10.1186/1471-2105-12-S7-A2

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BMC Bioinformatics

ISSN: 1471-2105

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