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Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects

A preliminary study

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Abstract

Neural tube defects are important causes of infant mortality and childhood morbidity. We investigated the relationship between zinc, selenium, copper, and lead concentrations and neural-tube-defect occurrence in women with a second-trimester termination due to fetal-neural-tube defects (NTDs) in this case-control study. Fourteen pregnant women whose pregnancies were terminated as a result of second-trimester ultrasonographic diagnosis of neural tube defects were recruited as cases. The control group (n=14) consisted of women who were selected among age-, gravidity-, and socio-economic-state (SES)-matched women who had a normal triple-screen and targeted ultrasound during the second trimester with documented normal fetal outcome. Zinc and copper determinations were made using flame atomic absorption spectrophotometer (AAS). Graphite furnace AAS was used for Pb, and Se levels were measured with hydride generation AAS. Cases had significantly low serum zinc and selenium levels (62.48±15.9 vs 102.6±23.7 and 55.16±11.3 vs 77.4±5.5, respectively, p<0.001). Serum Cu and whole-blood Pb levels were significantly high when compared to controls. There was a negative correlation between serum zinc and selenium levels, and serum copper levels (r=−425 and −0.443, p<0.05). Our results are consistent with some previous reports. The etiology of NTDs cannot be explained with one strict etiologic mechanism. On the contrary, an interaction among environmental, genetic, and nutritional factors such as trace elements and vitamins would explain these anomalies. If folic acid supplementation is given, additional Zn supplementation should be considered for the further decrease in the recurrence and occurrence of NTDs.

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References

  1. E. Tuncbilek, K. Boduroglu, and M. Alikasifoglu, Neural tube defects in Turkey: prevalence, distribution and risk factors, Turkish J Pediatr. 41, 299–305 (1999).

    CAS  Google Scholar 

  2. J. Elwood, J. Little, and J. Elwood, Epidemiology and Control of Neural Tube Defects, Oxford University Press, New York (1992).

    Google Scholar 

  3. J. Rankin, S. Glinianaia, R. Brown, et al., The changing prevalence of neural tube defects: a population-based study in the north of England, 1984–96. Northern Congenital Abnormality Survey Steering Group, Paediatr. Perinat. Epidemiol. 14, 104–110 (2000).

    Article  PubMed  CAS  Google Scholar 

  4. Medical Research Center, Vitamin Study Research Group, Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 338, 131–137 (1991).

    Article  Google Scholar 

  5. A. E. Czeizel and I. Dudas, Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327, 1832–1835 (1992).

    Article  PubMed  CAS  Google Scholar 

  6. A. O. Cavdar, A. Arcasoy, T. Baycu, et al., Zinc deficiency and anencephaly in Turkey, Teratology 22, 141 (1980).

    Article  PubMed  CAS  Google Scholar 

  7. A. O. Cavdar, E. Babacan, S. Asik, et al., Zinc levels of serum, plasma, erythrocytes and hair in Turkish women with anencephalic babies, in Zinc Deficiency in Human Subjects, A. S. Prasad, A. O. Cavdar, G. J. Brewer, et al., eds., Alan R. Liss, New York, pp. 99–105 (1983).

    Google Scholar 

  8. A. O. Cavdar, M. Bahceci, N. Akar, et al., Zinc status in pregnancy and the occurrence of anencephaly in Turkey, J. Trace Elements Electrolytes Health Dis. 2, 9–14 (1988).

    CAS  Google Scholar 

  9. A. O. Cavdar, M. Bahceci, N. Akar, et al., Maternal hair zinc concentration in neural tube defects in Turkey, Biol. Trace Element Res. 30, 81–86 (1991).

    CAS  Google Scholar 

  10. A. O. Cavdar, Zinc status during pregnancy in Turkish women, in Trace Elements in Humans, A. O. Cavdar, ed., TUBITAK, Ankara, pp. 21–34 (1997).

    Google Scholar 

  11. L. J. Hinks, A. Ogilvy-Stuart, K. M. Hambidge, et al., Maternal zinc and selenium status in pregnancies with a neural tube defect or elevated plasma alpha-fetoprotein, Br. J. Obstet. Gynaecol. 96, 61–66 (1989).

    PubMed  CAS  Google Scholar 

  12. H. Guvenc, F. Karatas, M. Guvenc, et al., Low levels of selenium in mothers and their newborns in pregnancies with a neural tube defect, Pediatrics 95, 879–882 (1995).

    PubMed  CAS  Google Scholar 

  13. K. S. O’Shea and M. H. Kaufman, Copper-induced microtubule degeneration and filamentous inclusions in the neuroepithelium of the mouse embryo, Acta Neuropathol. (Berl.) 49, 237–240 (1980).

    Article  CAS  Google Scholar 

  14. D. Graham, M. Enkin, and D. deSa, Neural tube defects in association with copper intrauterine devices, Int. J. Gynaecol. Obstet. 18, 404–405 (1980).

    PubMed  CAS  Google Scholar 

  15. C. L. Keen, J. Y. Uriu-Hare, S. N. Hawk, et al., Effect of copper deficiency on prenatal development and pregnancy outcome, Am. J. Clin. Nutr. 67, 1003S-1011S (1998).

    PubMed  CAS  Google Scholar 

  16. L. S. Hurley, Teratogenesis of trace element deficiency, Physiol. Rev. 61, 249–295 (1981).

    PubMed  CAS  Google Scholar 

  17. J. P. Bound, P. W. Harvey, B. J. Francis, et al., Involvement of deprivation and environmental lead in neural tube defects: a matched case-control study, Arch. Dis. Child. 76, 107–112 (1997).

    Article  PubMed  CAS  Google Scholar 

  18. F. Aydemir, A. O. Cavdar, and F. Soylemez, Zinc and selenium during pregnancy in Turkish women—a longitudional study, in New Aspects of Trace Element Research, M. Abdulla, M. Bost, and S. Gamon, eds., Smith-Gordon, London, pp. 288–292 (1999).

    Google Scholar 

  19. T. Tamura, K. E. Johnston, L. E. Freeberg, et al., Refrigeration of blood samples prior to separation is essential for the accurate determination of plasma or serum zinc concentrations, Biol. Trace Element Res. 41, 165–173 (1994).

    Article  CAS  Google Scholar 

  20. K. McLaughlin, D. Dadgar, M. R. Smyth, et al., Determination of selenium in blood plasma and serum by flow injection hydride generation atomic absorption spectrometry, Analyst 115, 275–278 (1990).

    Article  PubMed  Google Scholar 

  21. G. Shaw, E. Velie, and D. Schaffer, Risk of neural tube defect-affected pregnancies among obese women, JAMA 275, 1093–1096 (1996).

    Article  PubMed  CAS  Google Scholar 

  22. H. J. McArdle and C. J. Ashworth, Micronutrients in fetal growth and development, Br. Med. Bull. 55, 499–510 (1999).

    Article  PubMed  CAS  Google Scholar 

  23. C. T. Walsh, H. H. Sandstead, A. S. Prasad, et al., Zinc: health effects and research priorities for the 1990s, Environ. Health Perspect. 102(S2), 5–46 (1994).

    Article  PubMed  CAS  Google Scholar 

  24. G. Morris, Neural tube defects: towards prevention and understanding, Nature 284, 121–123 (1980).

    Article  Google Scholar 

  25. L. Hurley and H. Swenerton, Congenital malformations resulting from zinc deficiency in rats, Proc. Soc. Exp. Biol. Med. 123, 692–696 (1966).

    PubMed  CAS  Google Scholar 

  26. K. M. Hambidge, A. Hackshaw, and N. Wald, Neural tube defects and serum zinc, Br. J. Obstet. Gynaecol. 100, 746–749 (1993).

    PubMed  CAS  Google Scholar 

  27. K. M. Hambidge, K. H. Neldner, and P. A. Walravens, Zinc, acrodermatitis enteropathica and congenital malformations, Lancet 1, 577 (1975).

    Article  Google Scholar 

  28. E. M. Velie, G. Block, G. M. Shaw, et al., Maternal supplemental and dietary zinc intake and the occurrence of neural tube defects in California, Am. J. Epidemiol. 150, 605–616 (1999).

    PubMed  CAS  Google Scholar 

  29. D. B. Milne, W. K. Canfield, J. R. Mahalko, et al., Effect of oral folic acid supplements on zinc, copper, and iron absorption and excretion, Am. J. Clin. Nutr. 39, 535–539 (1984).

    PubMed  CAS  Google Scholar 

  30. M. B. Zimmermann and B. Shane, Supplemental folic acid, Am. J. Clin. Nutr. 58, 127–128 (1993).

    PubMed  CAS  Google Scholar 

  31. A. O. Cavdar, Analysis of zinc (serum, plasma, erythrocyte and hair zinc) and its relation to nutrition in pregnant Turkish women: a review of cross-sectional and longitudional studies, J. Trace Elements Exp. Med. 13, 63–71 (2000).

    Article  CAS  Google Scholar 

  32. G. Saner and M. Yuksel, The role of trace element status in prenatal development, in Current Trends in Trace Element Research: Proceedings of International Symposium on Trace Elements. Paris, 1987, G. Chazot, M. Abdulla, and P. Arnaud, eds., Smith-Gordon, London, pp. 79–85 (1989).

    Google Scholar 

  33. G. J. Brewer, V. D. Johnson, R. D. Dick, et al., Treatment of Wilson’s disease with zinc. XVII: treatment during pregnancy, Hepatology 31, 364–370 (2000).

    Article  PubMed  CAS  Google Scholar 

  34. D. Bryce-Smith, R. R. Deshpande, J. Hughes, et al., Lead and cadmium levels in stillbirths, Lancet 1, 1159 (1997).

    Google Scholar 

  35. S. Jameson, Zinc status in pregnancy: the effect of zinc therapy on perinatal mortality, prematurity, and placental ablation, Ann. NY Acad. Sci. 678, 178–192 (1993).

    Article  PubMed  CAS  Google Scholar 

  36. World Health Organization, Air quality guidelines for Europe. WHO Reg. Publ. Eur. Ser. 91(V-X), 1–273 (2000).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Ankara University School of Medicine, Ankara, Turkey

    Bora Cengiz, Feride Söylemez & Ebru Öztürk

  2. Turkish Academy of Sciences (TUBA) Trace Element Working Group, and UNESCO Satellite Trace Element Center in Pediatric Hematology-Oncology Research Center of Ankara University, Ankara, Turkey

    Ayhan O. Çavdar

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  1. Bora Cengiz
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Cengiz, B., Söylemez, F., Öztürk, E. et al. Serum zinc, selenium, copper, and lead levels in women with second-trimester induced abortion resulting from neural tube defects. Biol Trace Elem Res 97, 225–235 (2004). https://doi.org/10.1385/BTER:97:3:225

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  • DOI: https://doi.org/10.1385/BTER:97:3:225

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