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Diatoms Biosilica as Efficient Drug-Delivery System

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Abstract

Diatoms are the most abundant resource of biosilica on Earth. These microalgae are encased in a 3-D amorphous silica “shell” called frustule whose size and morphology is strictly dependent on the diatom species. Naturally nanostructured biosilica from diatoms exhibit unique adsorption and confinement properties useful for delivery of molecules of pharmacological interest.In this work fossil biosilica was used as a carrier for Ophiobolin A (a fungal macrolide with anticancer and antiparasitic properties), with the aim to develop a model system of Ophiobolin A loading / delivery. Ophiobolin A delivery properties of fossil diatoms were investigated by spectophotometric analyses.

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Authors and Affiliations

  1. Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”, Via Orabona, 4, 70126, Bari, Italy

    Danilo Vona, Gabriella Leone, Roberta Ragni & Gianluca M. Farinola

  2. CNR NANOTECH, Via Orabona, 4, 70126, Bari, Italy

    Fabio Palumbo

  3. Dipartimento di Scienze Chimiche, Complesso Universitario Monte Sant’Angelo, Via Cintia 4, 80126, Napoli, Italy

    Antonio Evidente

  4. CNR ISPA, Via Amendola, 122/O, 70125, Bari, Italy

    Maurizio Vurro

  5. CNR ICCOM, Via Orabona, 4, 70126, Bari, Italy

    Stefania R. Cicco

Authors
  1. Danilo Vona
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  2. Gabriella Leone
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  3. Roberta Ragni
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  4. Fabio Palumbo
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  5. Antonio Evidente
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  6. Maurizio Vurro
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  7. Gianluca M. Farinola
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  8. Stefania R. Cicco
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Vona, D., Leone, G., Ragni, R. et al. Diatoms Biosilica as Efficient Drug-Delivery System. MRS Advances 1, 3825–3830 (2016). https://doi.org/10.1557/adv.2015.22

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  • DOI: https://doi.org/10.1557/adv.2015.22

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