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Rodent models of focal stroke: Size, mechanism, and purpose

  • Published: July 2005
  • Volume 2, pages 396–409, (2005)
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NeuroRX
Rodent models of focal stroke: Size, mechanism, and purpose
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  • S. Thomas Carmichael1 

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Summary

Rodent stroke models provide the experimental backbone for the in vivo determination of the mechanisms of cell death and neural repair, and for the initial testing of neuroprotective compounds. Less than 10 rodent models of focal stroke are routinely used in experimental study. These vary widely in their ability to model the human disease, and in their application to the study of cell death or neural repair. Many rodent focal stroke models produce large infarcts that more closely resemble malignant and fatal human infarction than the average sized human stroke. This review focuses on the mechanisms of ischemic damage in rat and mouse stroke models, the relative size of stroke generated in each model, and the purpose with which focal stroke models are applied to the study of ischemic cell death and to neural repair after stroke.

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  1. Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, 90095, Los Angeles, CA

    S. Thomas Carmichael

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Carmichael, S.T. Rodent models of focal stroke: Size, mechanism, and purpose. Neurotherapeutics 2, 396–409 (2005). https://doi.org/10.1602/neurorx.2.3.396

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  • Issue Date: July 2005

  • DOI: https://doi.org/10.1602/neurorx.2.3.396

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Key Words

  • Necrosis
  • apoptosis
  • neural repair
  • malignant infarction
  • rat
  • mouse
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