Health informatics has been promoted as a core curriculum in our patient safety program for four years. There is a need to let students understand how such topics were addressed with relevant literature of trends in medical informatics. In this study, we performed a content analysis by searching the past five MEDINFO Congress Proceedings. We used MeSH Terms or Keywords to search the study subjects and divided them into three categories. 76 subjects were identified, among which 16 were assigned to Category 1 (System-related), 26 to Category 2 (Database-related), and 34 to Category 3 (Others). Some socio-techical issues that emerged in Category 3 presented as future research interests.The identified topics reflect research trends in patient safety.