Patient privacy concerns are often cited as a barrier to health information exchange (HIE) implementations; however, the current understanding of patient perspective is limited due to a fragmented approach to patient privacy research. The limited evidence suggests that the patient privacy perspective is context-dependent and may involve benefit-risk tradeoffs. A standardized approach to the contextual factors would allow for more consistent assessment, providing a better understanding or explanation of the contextual factors influencing the patient privacy perspective and their attitudes towards HIE. This paper describes the development of the eHealth Trust Model—an evidence-based theory-grounded conceptual framework intended to guide future patient privacy research.