Health Smart Homes are a promising part of digital personalized health care. However, engineering of the underlying residential assistance systems is a complex process that needs to be supported by computer-based design tools. This paper presents a formal definition for the engineering task and proposes a methodology for model-driven design process automation, that is implemented in a web-based pilot application. Using this approach for design support, the challenge to efficiently compose personalized assistance systems for patients can be coped with in the future, which reduces a major barrier for smart home assistance applications.