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Changes in the EEG-Rhythms in Endogenous Depressive Disorders and the Effect of Pharmacotherapy

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Abstract

The study of a series of EEG indices in endogenous depressive disorders and their changes after pharmacotherapy was conducted. The EEG changes in depressed patients versus healthy individuals were found to be characterized by a significant increase in the relative power of the Δ- and θ-activity and a decrease in the α- and β-activity, as well as by a decrease in the regional differences between the anterior and posterior divisions of the brain and an increase in the activity of the right hemisphere in relation to the left hemisphere. The use of amitriptyline, fluoxetine, and moclobemide contributed to the improvement in the mental state, which was accompanied by an increase in the EEG amplitude, a decrease in the relative power of the Δ- and θ-activity, and an increase in the α-rhythm power; however, on discharge, the patients retained deviations from a number of values compared to healthy subjects.

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Authors and Affiliations

  1. Rostov State Medical University, Rostov-on Don, Russia

    V. P. Omel'chenko & V. G. Zaika

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  1. V. P. Omel'chenko
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  2. V. G. Zaika
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Omel'chenko, V.P., Zaika, V.G. Changes in the EEG-Rhythms in Endogenous Depressive Disorders and the Effect of Pharmacotherapy. Human Physiology 28, 275–281 (2002). https://doi.org/10.1023/A:1015596416791

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