Issue 10, 2007
From the journal:

Organic & Biomolecular Chemistry

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

Christopher D. Smith,a   Ian R. Baxendale,a   Steve Lanners,a   John J. Hayward,a   Stephen C. Smithb  and  Steven V. Ley*a  

* Corresponding authors

a Innovative Technology Centre (ACS), Department of Chemistry, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk
Fax: +44 1223 336442
Tel: +44 1223 336398

b Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, UK

Abstract

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

Graphical abstract: [3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

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Article information

DOI
https://doi.org/10.1039/B702995K
Article type
Paper
Submitted
27 Feb 2007
Accepted
19 Mar 2007
First published
16 Apr 2007

Org. Biomol. Chem., 2007,5, 1559-1561

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[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

C. D. Smith, I. R. Baxendale, S. Lanners, J. J. Hayward, S. C. Smith and S. V. Ley, Org. Biomol. Chem., 2007, 5, 1559 DOI: 10.1039/B702995K

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