Continuous wave terahertz reflection imaging of human colorectal tissue

Pallavi Doradla; Karim Alavi; Cecil S. Joseph; Robert H. Giles

doi:10.1117/12.2004385

27 March 2013 Continuous wave terahertz reflection imaging of human colorectal tissue

Pallavi Doradla, Karim Alavi, Cecil S. Joseph, Robert H. Giles

Proceedings Volume 8624, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VI; 86240O (2013) https://doi.org/10.1117/12.2004385
Event: SPIE OPTO, 2013, San Francisco, California, United States

Abstract

Continuous wave terahertz (THz) imaging has the potential to offer a safe, non-ionizing, and nondestructive medical imaging modality for delineating colorectal cancer. Fresh excisions of normal colon tissue were obtained from surgeries performed at the University of Massachusetts Medical School, Worcester. Reflection measurements of thick sections of colorectal tissues, mounted in an aluminum sample holder, were obtained for both fresh and formalin fixed tissues. The two-dimensional reflection images were acquired by using an optically pumped far-infrared molecular gas laser operating at 584 GHz with liquid Helium cooled silicon bolometer detector. Using polarizers in the experiment both co-polarized and cross-polarized remittance form the samples was collected. Analysis of the images showed the importance of understanding the effects of formalin fixation while determining reflectance level of tissue response. The resulting co- and cross-polarized images of both normal and formalin fixed tissues showed uniform terahertz response over the entire sample area. Initial measurements indicated a co-polarized reflectance of 16%, and a cross-polarized reflectance of 0.55% from fresh excisions of normal colonic tissues.

Citation Download Citation

Pallavi Doradla, Karim Alavi, Cecil S. Joseph, and Robert H. Giles "Continuous wave terahertz reflection imaging of human colorectal tissue", Proc. SPIE 8624, Terahertz, RF, Millimeter, and Submillimeter-Wave Technology and Applications VI, 86240O (27 March 2013); https://doi.org/10.1117/12.2004385

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