Abstract
Nucleocytoplasmic large dsDNA viruses (NCLDVs) encompass an ever-increasing group of large eukaryotic viruses, infecting a wide variety of organisms. The set of core genes shared by all these viruses includes a major capsid protein with a double jelly-roll fold forming an icosahedral capsid, which surrounds a double layer membrane that contains the viral genome. Furthermore, some of these viruses, such as the members of the Mimiviridae and Phycodnaviridae have a unique vertex that is used during infection to transport DNA into the host.
About the authors
Thomas Klose studied biochemistry at the Martin-Luther-Universität Halle-Wittenberg. He received his PhD in biochemistry from the Martin-Luther-Universität Halle-Wittenberg, where he worked within the framework of the GRK1026 on the assembly of virus-like-particles in the group of Hauke Lilie. He is currently working in the Rossmann group at Purdue University on the structure of large viruses.
Michael G. Rossmann was born in Frankfurt, Germany and studied physics and mathematics at the University of London. He received his PhD in chemical crystallography in 1956 from the University of Glasgow. He worked as a postdoc with William N. Lipscomb, Jr. at the University of Minnesota before returning to the UK and where he worked with Max Perutz on the structure of hemoglobin at the MRC Laboratory at the University of Cambridge. In 1964 he became a faculty member in the Department of Biological Sciences at Purdue University. He was promoted to full professor in 1967 and is the Hanley Distinguished Professor of Biological Sciences since 1978. Additionally, he has adjunct positions at Cornell University as well as Indiana University’s School of Medicine. He is an elected member of the National Academy of Sciences, a Foreign Fellow of the Indian National Science Academy and an Elected Foreign Member of the Royal Society of London. Among other honors he was awarded honorary doctorates by the University of Uppsala in Sweden, the University of Strasbourg in France, the Vrije Universiteit Brussel in Belgium, the University of Glasgow in Scotland, University of York in England and the University of Québec in Canada.
Acknowledgments
The authors are grateful for financial support from the National Institutes of Health (AI011219 to M.G.R.).
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