DC5 or DC-5 may refer to:
- DC5, municipality code for Central Karoo District Municipality, South Africa
- DC-5, a game offered by the D.C. Lottery
- Douglas DC-5, a twin-propeller passenger aircraft
- Honda Integra DC5, a Japanese sports car known as the Acura RSX in North America
- The D.C. Five, five U.S. citizens convicted by Pakistan of plotting terrorist attacks
- The Dave Clark Five, a British rock group
- Defense Condition 5, a well known team from the Battlefield series