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Neutrophil: Difference between revisions

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→‎Life span: Remove redundancy that could be confusing: : "5 days and 15 hours" could be interpreted by readers as another low-to-high range
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File:Histopathology of thalamus infarction at approximately 24 hours, high magnification, annotated.jpg|In [[stroke]], they are beginning to infiltrate the infarcted brain after 6 to 8 hours.<ref name="JicklingLiu2015">{{cite journal | vauthors = Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR | title = Targeting neutrophils in ischemic stroke: translational insights from experimental studies | journal = Journal of Cerebral Blood Flow and Metabolism | volume = 35 | issue = 6 | pages = 888–901 | date = June 2015 | pmid = 25806703 | pmc = 4640255 | doi = 10.1038/jcbfm.2015.45 }}</ref>
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== Pathogen evasion and resistance ==
{{See also|Phagocyte#Pathogen evasion and resistance}}
Just like phagocytes, pathogens may evade or infect neutrophils.<ref name=":1">{{Cite journal|last=Kobayashi |first=Scott D.|last2=Malachowa|first2=Natalia|last3=DeLeo|first3=Frank R.|date=2018 |title=Neutrophils and Bacterial Immune Evasion |url=https://www.karger.com/Article/FullText/487756 |journal=Journal of Innate Immunity |language=en |volume=10 |issue=5-6 |pages=432–441 |doi=10.1159/000487756 |issn=1662-811X |pmc=PMC6784029 |pmid=29642066}}</ref> Some bacterial pathogens evolved various mechanisms such as virulence molecules to avoid being killed by neutrophils. These molecules collectively may alter or disrupt neutrophil recruitment, apoptosis or bactericidal activity.<ref name=":1" />
 
Neutrophils can also serve as host cell for various parasites that infects them avoding phagocytosis, including:
 
* [[Leishmania major]] – uses neutrophils as vehicle to parasitize phagocytes<ref>{{Cite journal |last=Ritter |first=Uwe |last2=Frischknecht |first2=Freddy |last3=van Zandbergen |first3=Ger |date=November 2009 |title=Are neutrophils important host cells for Leishmania parasites? |url=https://linkinghub.elsevier.com/retrieve/pii/S1471492209001792 |journal=Trends in Parasitology |language=en |volume=25 |issue=11 |pages=505–510 |doi=10.1016/j.pt.2009.08.003}}</ref>
* [[Mycobacterium tuberculosis|M. tuberculosis]]<ref name=":2">{{Cite journal |last=Parker |first=Heather A. |last2=Forrester |first2=Lorna |last3=Kaldor |first3=Christopher D. |last4=Dickerhof |first4=Nina |last5=Hampton |first5=Mark B. |date=2021-12-23 |title=Antimicrobial Activity of Neutrophils Against Mycobacteria |url=https://www.frontiersin.org/articles/10.3389/fimmu.2021.782495/full |journal=Frontiers in Immunology |volume=12 |doi=10.3389/fimmu.2021.782495 |issn=1664-3224 |pmc=PMC8732375 |pmid=35003097}}</ref>
* [[M. leprae]]<ref name=":2" />
* [[Yersinia pestis]]<ref name=":3">{{Cite journal |last=Parker |first=Heather A. |last2=Forrester |first2=Lorna |last3=Kaldor |first3=Christopher D. |last4=Dickerhof |first4=Nina |last5=Hampton |first5=Mark B. |date=2021-12-23 |title=Antimicrobial Activity of Neutrophils Against Mycobacteria |url=https://www.frontiersin.org/articles/10.3389/fimmu.2021.782495/full |journal=Frontiers in Immunology |volume=12 |doi=10.3389/fimmu.2021.782495 |issn=1664-3224 |pmc=PMC8732375 |pmid=35003097}}</ref>
* [[Chlamydia pneumoniae]]<ref name=":3" />
 
==Neutrophil antigens==